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The long-term outcome of orthostatic tremor

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The long-term outcome of orthostatic tremor. / Ganos, Christos; Maugest, Lucie; Apartis, Emmanuelle; Gasca-Salas, Carmen; Cáceres-Redondo, María T; Erro, Roberto; Navalpotro-Gómez, Irene; Batla, Amit; Antelmi, Elena; Degos, Bertrand; Roze, Emmanuel; Welter, Marie-Laure; Mestre, Tiago; Palomar, Francisco J; Isayama, Reina; Chen, Robert; Cordivari, Carla; Mir, Pablo; Lang, Anthony E; Fox, Susan H; Bhatia, Kailash P; Vidailhet, Marie.

in: J NEUROL NEUROSUR PS, Jahrgang 87, Nr. 2, 02.2016, S. 167-72.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ganos, C, Maugest, L, Apartis, E, Gasca-Salas, C, Cáceres-Redondo, MT, Erro, R, Navalpotro-Gómez, I, Batla, A, Antelmi, E, Degos, B, Roze, E, Welter, M-L, Mestre, T, Palomar, FJ, Isayama, R, Chen, R, Cordivari, C, Mir, P, Lang, AE, Fox, SH, Bhatia, KP & Vidailhet, M 2016, 'The long-term outcome of orthostatic tremor', J NEUROL NEUROSUR PS, Jg. 87, Nr. 2, S. 167-72. https://doi.org/10.1136/jnnp-2014-309942

APA

Ganos, C., Maugest, L., Apartis, E., Gasca-Salas, C., Cáceres-Redondo, M. T., Erro, R., Navalpotro-Gómez, I., Batla, A., Antelmi, E., Degos, B., Roze, E., Welter, M-L., Mestre, T., Palomar, F. J., Isayama, R., Chen, R., Cordivari, C., Mir, P., Lang, A. E., ... Vidailhet, M. (2016). The long-term outcome of orthostatic tremor. J NEUROL NEUROSUR PS, 87(2), 167-72. https://doi.org/10.1136/jnnp-2014-309942

Vancouver

Ganos C, Maugest L, Apartis E, Gasca-Salas C, Cáceres-Redondo MT, Erro R et al. The long-term outcome of orthostatic tremor. J NEUROL NEUROSUR PS. 2016 Feb;87(2):167-72. https://doi.org/10.1136/jnnp-2014-309942

Bibtex

@article{75f83ec061444a1c9b88cbf0cc7c114b,
title = "The long-term outcome of orthostatic tremor",
abstract = "OBJECTIVES: Orthostatic tremor is a rare condition characterised by high-frequency tremor that appears on standing. Although the essential clinical features of orthostatic tremor are well established, little is known about the natural progression of the disorder. We report the long-term outcome based on the largest multicentre cohort of patients with orthostatic tremor.METHODS: Clinical information of 68 patients with clinical and electrophysiological diagnosis of orthostatic tremor and a minimum follow-up of 5 years is presented.RESULTS: There was a clear female preponderance (76.5%) with a mean age of onset at 54 years. Median follow-up was 6 years (range 5-25). On diagnosis, 86.8% of patients presented with isolated orthostatic tremor and 13.2% had additional neurological features. At follow-up, seven patients who initially had isolated orthostatic tremor later developed further neurological signs. A total 79.4% of patients reported worsening of orthostatic tremor symptoms. These patients had significantly longer symptom duration than those without reported worsening (median 15.5 vs 10.5 years, respectively; p=0.005). There was no change in orthostatic tremor frequency over time. Structural imaging was largely unremarkable and dopaminergic neuroimaging (DaTSCAN) was normal in 18/19 cases. Pharmacological treatments were disappointing. Two patients were treated surgically and showed improvement.CONCLUSIONS: Orthostatic tremor is a progressive disorder with increased disability although tremor frequency is unchanged over time. In most cases, orthostatic tremor represents an isolated syndrome. Drug treatments are unsatisfactory but surgery may hold promise.",
keywords = "Age of Onset, Aged, Aged, 80 and over, Cohort Studies, Disease Progression, Dopaminergic Neurons, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuroimaging, Neurosurgical Procedures, Sex Factors, Spinal Cord Stimulation, Treatment Outcome, Tremor, Journal Article, Multicenter Study",
author = "Christos Ganos and Lucie Maugest and Emmanuelle Apartis and Carmen Gasca-Salas and C{\'a}ceres-Redondo, {Mar{\'i}a T} and Roberto Erro and Irene Navalpotro-G{\'o}mez and Amit Batla and Elena Antelmi and Bertrand Degos and Emmanuel Roze and Marie-Laure Welter and Tiago Mestre and Palomar, {Francisco J} and Reina Isayama and Robert Chen and Carla Cordivari and Pablo Mir and Lang, {Anthony E} and Fox, {Susan H} and Bhatia, {Kailash P} and Marie Vidailhet",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/",
year = "2016",
month = feb,
doi = "10.1136/jnnp-2014-309942",
language = "English",
volume = "87",
pages = "167--72",
journal = "J NEUROL NEUROSUR PS",
issn = "0022-3050",
publisher = "BMJ PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - The long-term outcome of orthostatic tremor

AU - Ganos, Christos

AU - Maugest, Lucie

AU - Apartis, Emmanuelle

AU - Gasca-Salas, Carmen

AU - Cáceres-Redondo, María T

AU - Erro, Roberto

AU - Navalpotro-Gómez, Irene

AU - Batla, Amit

AU - Antelmi, Elena

AU - Degos, Bertrand

AU - Roze, Emmanuel

AU - Welter, Marie-Laure

AU - Mestre, Tiago

AU - Palomar, Francisco J

AU - Isayama, Reina

AU - Chen, Robert

AU - Cordivari, Carla

AU - Mir, Pablo

AU - Lang, Anthony E

AU - Fox, Susan H

AU - Bhatia, Kailash P

AU - Vidailhet, Marie

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

PY - 2016/2

Y1 - 2016/2

N2 - OBJECTIVES: Orthostatic tremor is a rare condition characterised by high-frequency tremor that appears on standing. Although the essential clinical features of orthostatic tremor are well established, little is known about the natural progression of the disorder. We report the long-term outcome based on the largest multicentre cohort of patients with orthostatic tremor.METHODS: Clinical information of 68 patients with clinical and electrophysiological diagnosis of orthostatic tremor and a minimum follow-up of 5 years is presented.RESULTS: There was a clear female preponderance (76.5%) with a mean age of onset at 54 years. Median follow-up was 6 years (range 5-25). On diagnosis, 86.8% of patients presented with isolated orthostatic tremor and 13.2% had additional neurological features. At follow-up, seven patients who initially had isolated orthostatic tremor later developed further neurological signs. A total 79.4% of patients reported worsening of orthostatic tremor symptoms. These patients had significantly longer symptom duration than those without reported worsening (median 15.5 vs 10.5 years, respectively; p=0.005). There was no change in orthostatic tremor frequency over time. Structural imaging was largely unremarkable and dopaminergic neuroimaging (DaTSCAN) was normal in 18/19 cases. Pharmacological treatments were disappointing. Two patients were treated surgically and showed improvement.CONCLUSIONS: Orthostatic tremor is a progressive disorder with increased disability although tremor frequency is unchanged over time. In most cases, orthostatic tremor represents an isolated syndrome. Drug treatments are unsatisfactory but surgery may hold promise.

AB - OBJECTIVES: Orthostatic tremor is a rare condition characterised by high-frequency tremor that appears on standing. Although the essential clinical features of orthostatic tremor are well established, little is known about the natural progression of the disorder. We report the long-term outcome based on the largest multicentre cohort of patients with orthostatic tremor.METHODS: Clinical information of 68 patients with clinical and electrophysiological diagnosis of orthostatic tremor and a minimum follow-up of 5 years is presented.RESULTS: There was a clear female preponderance (76.5%) with a mean age of onset at 54 years. Median follow-up was 6 years (range 5-25). On diagnosis, 86.8% of patients presented with isolated orthostatic tremor and 13.2% had additional neurological features. At follow-up, seven patients who initially had isolated orthostatic tremor later developed further neurological signs. A total 79.4% of patients reported worsening of orthostatic tremor symptoms. These patients had significantly longer symptom duration than those without reported worsening (median 15.5 vs 10.5 years, respectively; p=0.005). There was no change in orthostatic tremor frequency over time. Structural imaging was largely unremarkable and dopaminergic neuroimaging (DaTSCAN) was normal in 18/19 cases. Pharmacological treatments were disappointing. Two patients were treated surgically and showed improvement.CONCLUSIONS: Orthostatic tremor is a progressive disorder with increased disability although tremor frequency is unchanged over time. In most cases, orthostatic tremor represents an isolated syndrome. Drug treatments are unsatisfactory but surgery may hold promise.

KW - Age of Onset

KW - Aged

KW - Aged, 80 and over

KW - Cohort Studies

KW - Disease Progression

KW - Dopaminergic Neurons

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Neuroimaging

KW - Neurosurgical Procedures

KW - Sex Factors

KW - Spinal Cord Stimulation

KW - Treatment Outcome

KW - Tremor

KW - Journal Article

KW - Multicenter Study

U2 - 10.1136/jnnp-2014-309942

DO - 10.1136/jnnp-2014-309942

M3 - SCORING: Journal article

C2 - 25770124

VL - 87

SP - 167

EP - 172

JO - J NEUROL NEUROSUR PS

JF - J NEUROL NEUROSUR PS

SN - 0022-3050

IS - 2

ER -