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The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory

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The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory. / Muhia, Mary; Thies, Edda; Labonté, Dorthe; Ghiretti, Amy E; Gromova, Kira V; Xompero, Francesca; Lappe-Siefke, Corinna; Hermans-Borgmeyer, Irm; Kuhl, Dietmar; Schweizer, Michaela; Ohana, Ora; Schwarz, Jürgen; Holzbaur, Erika L F; Kneussel, Matthias.

in: CELL REP, Jahrgang 15, Nr. 5, 03.05.2016, S. 968-77.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Muhia, M, Thies, E, Labonté, D, Ghiretti, AE, Gromova, KV, Xompero, F, Lappe-Siefke, C, Hermans-Borgmeyer, I, Kuhl, D, Schweizer, M, Ohana, O, Schwarz, J, Holzbaur, ELF & Kneussel, M 2016, 'The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory', CELL REP, Jg. 15, Nr. 5, S. 968-77. https://doi.org/10.1016/j.celrep.2016.03.086

APA

Muhia, M., Thies, E., Labonté, D., Ghiretti, A. E., Gromova, K. V., Xompero, F., Lappe-Siefke, C., Hermans-Borgmeyer, I., Kuhl, D., Schweizer, M., Ohana, O., Schwarz, J., Holzbaur, E. L. F., & Kneussel, M. (2016). The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory. CELL REP, 15(5), 968-77. https://doi.org/10.1016/j.celrep.2016.03.086

Vancouver

Muhia M, Thies E, Labonté D, Ghiretti AE, Gromova KV, Xompero F et al. The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory. CELL REP. 2016 Mai 3;15(5):968-77. https://doi.org/10.1016/j.celrep.2016.03.086

Bibtex

@article{fa14729f3bcc45df9b89dc594c4e1273,
title = "The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory",
abstract = "The kinesin KIF21B is implicated in several human neurological disorders, including delayed cognitive development, yet it remains unclear how KIF21B dysfunction may contribute to pathology. One limitation is that relatively little is known about KIF21B-mediated physiological functions. Here, we generated Kif21b knockout mice and used cellular assays to investigate the relevance of KIF21B in neuronal and in vivo function. We show that KIF21B is a processive motor protein and identify an additional role for KIF21B in regulating microtubule dynamics. In neurons lacking KIF21B, microtubules grow more slowly and persistently, leading to tighter packing in dendrites. KIF21B-deficient neurons exhibit decreased dendritic arbor complexity and reduced spine density, which correlate with deficits in synaptic transmission. Consistent with these observations, Kif21b-null mice exhibit behavioral changes involving learning and memory deficits. Our study provides insight into the cellular function of KIF21B and the basis for cognitive decline resulting from KIF21B dysregulation.",
keywords = "Journal Article, Synapses, Learning, Memory, Neuronal Plasticity",
author = "Mary Muhia and Edda Thies and Dorthe Labont{\'e} and Ghiretti, {Amy E} and Gromova, {Kira V} and Francesca Xompero and Corinna Lappe-Siefke and Irm Hermans-Borgmeyer and Dietmar Kuhl and Michaela Schweizer and Ora Ohana and J{\"u}rgen Schwarz and Holzbaur, {Erika L F} and Matthias Kneussel",
note = "Copyright {\textcopyright} 2016 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2016",
month = may,
day = "3",
doi = "10.1016/j.celrep.2016.03.086",
language = "English",
volume = "15",
pages = "968--77",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory

AU - Muhia, Mary

AU - Thies, Edda

AU - Labonté, Dorthe

AU - Ghiretti, Amy E

AU - Gromova, Kira V

AU - Xompero, Francesca

AU - Lappe-Siefke, Corinna

AU - Hermans-Borgmeyer, Irm

AU - Kuhl, Dietmar

AU - Schweizer, Michaela

AU - Ohana, Ora

AU - Schwarz, Jürgen

AU - Holzbaur, Erika L F

AU - Kneussel, Matthias

N1 - Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2016/5/3

Y1 - 2016/5/3

N2 - The kinesin KIF21B is implicated in several human neurological disorders, including delayed cognitive development, yet it remains unclear how KIF21B dysfunction may contribute to pathology. One limitation is that relatively little is known about KIF21B-mediated physiological functions. Here, we generated Kif21b knockout mice and used cellular assays to investigate the relevance of KIF21B in neuronal and in vivo function. We show that KIF21B is a processive motor protein and identify an additional role for KIF21B in regulating microtubule dynamics. In neurons lacking KIF21B, microtubules grow more slowly and persistently, leading to tighter packing in dendrites. KIF21B-deficient neurons exhibit decreased dendritic arbor complexity and reduced spine density, which correlate with deficits in synaptic transmission. Consistent with these observations, Kif21b-null mice exhibit behavioral changes involving learning and memory deficits. Our study provides insight into the cellular function of KIF21B and the basis for cognitive decline resulting from KIF21B dysregulation.

AB - The kinesin KIF21B is implicated in several human neurological disorders, including delayed cognitive development, yet it remains unclear how KIF21B dysfunction may contribute to pathology. One limitation is that relatively little is known about KIF21B-mediated physiological functions. Here, we generated Kif21b knockout mice and used cellular assays to investigate the relevance of KIF21B in neuronal and in vivo function. We show that KIF21B is a processive motor protein and identify an additional role for KIF21B in regulating microtubule dynamics. In neurons lacking KIF21B, microtubules grow more slowly and persistently, leading to tighter packing in dendrites. KIF21B-deficient neurons exhibit decreased dendritic arbor complexity and reduced spine density, which correlate with deficits in synaptic transmission. Consistent with these observations, Kif21b-null mice exhibit behavioral changes involving learning and memory deficits. Our study provides insight into the cellular function of KIF21B and the basis for cognitive decline resulting from KIF21B dysregulation.

KW - Journal Article

KW - Synapses

KW - Learning

KW - Memory

KW - Neuronal Plasticity

U2 - 10.1016/j.celrep.2016.03.086

DO - 10.1016/j.celrep.2016.03.086

M3 - SCORING: Journal article

C2 - 27117409

VL - 15

SP - 968

EP - 977

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 5

ER -