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The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling

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The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling. / Gromova, Kira V; Thies, Edda; Janiesch, Philipp C; Lützenkirchen, Felix P; Zhu, Yipeng; Stajano, Daniele; Dürst, Céline D; Schweizer, Michaela; Konietzny, Anja; Mikhaylova, Marina; Gee, Christine E; Kneussel, Matthias.

in: CELL REP, Jahrgang 42, Nr. 7, 112743, 25.07.2023, S. 1-24.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gromova, KV, Thies, E, Janiesch, PC, Lützenkirchen, FP, Zhu, Y, Stajano, D, Dürst, CD, Schweizer, M, Konietzny, A, Mikhaylova, M, Gee, CE & Kneussel, M 2023, 'The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling', CELL REP, Jg. 42, Nr. 7, 112743, S. 1-24. https://doi.org/10.1016/j.celrep.2023.112743

APA

Gromova, K. V., Thies, E., Janiesch, P. C., Lützenkirchen, F. P., Zhu, Y., Stajano, D., Dürst, C. D., Schweizer, M., Konietzny, A., Mikhaylova, M., Gee, C. E., & Kneussel, M. (2023). The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling. CELL REP, 42(7), 1-24. [112743]. https://doi.org/10.1016/j.celrep.2023.112743

Vancouver

Gromova KV, Thies E, Janiesch PC, Lützenkirchen FP, Zhu Y, Stajano D et al. The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling. CELL REP. 2023 Jul 25;42(7):1-24. 112743. https://doi.org/10.1016/j.celrep.2023.112743

Bibtex

@article{867f097302be49c494609ef61d90a49e,
title = "The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling",
abstract = "Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic guanylate kinase-associated protein (GKAP) controls the bidirectional synaptic scaling of AMPA receptors (AMPARs); however, mechanisms by which chronic activity triggers cytoskeletal remodeling to downscale synaptic transmission are barely understood. Here, we report that the microtubule-dependent kinesin motor Kif21b binds GKAP and likewise is located in dendritic spines in a myosin Va- and neuronal-activity-dependent manner. Kif21b depletion unexpectedly alters actin dynamics in spines, and adaptation of actin turnover following chronic activity is lost in Kif21b-knockout neurons. Consistent with a role of the kinesin in regulating actin dynamics, Kif21b overexpression promotes actin polymerization. Moreover, Kif21b controls GKAP removal from spines and the decrease of GluA2-containing AMPARs from the neuronal surface, thereby inducing homeostatic synaptic downscaling. Our data highlight a critical role of Kif21b at the synaptic actin cytoskeleton underlying homeostatic scaling of neuronal firing.",
keywords = "Actins/metabolism, Kinesins/metabolism, Neurons/metabolism, Neuronal Plasticity/physiology, Synapses/metabolism, Myosins/metabolism, Dendritic Spines/metabolism",
author = "Gromova, {Kira V} and Edda Thies and Janiesch, {Philipp C} and L{\"u}tzenkirchen, {Felix P} and Yipeng Zhu and Daniele Stajano and D{\"u}rst, {C{\'e}line D} and Michaela Schweizer and Anja Konietzny and Marina Mikhaylova and Gee, {Christine E} and Matthias Kneussel",
note = "Copyright {\textcopyright} 2023 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2023",
month = jul,
day = "25",
doi = "10.1016/j.celrep.2023.112743",
language = "English",
volume = "42",
pages = "1--24",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "7",

}

RIS

TY - JOUR

T1 - The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling

AU - Gromova, Kira V

AU - Thies, Edda

AU - Janiesch, Philipp C

AU - Lützenkirchen, Felix P

AU - Zhu, Yipeng

AU - Stajano, Daniele

AU - Dürst, Céline D

AU - Schweizer, Michaela

AU - Konietzny, Anja

AU - Mikhaylova, Marina

AU - Gee, Christine E

AU - Kneussel, Matthias

N1 - Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2023/7/25

Y1 - 2023/7/25

N2 - Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic guanylate kinase-associated protein (GKAP) controls the bidirectional synaptic scaling of AMPA receptors (AMPARs); however, mechanisms by which chronic activity triggers cytoskeletal remodeling to downscale synaptic transmission are barely understood. Here, we report that the microtubule-dependent kinesin motor Kif21b binds GKAP and likewise is located in dendritic spines in a myosin Va- and neuronal-activity-dependent manner. Kif21b depletion unexpectedly alters actin dynamics in spines, and adaptation of actin turnover following chronic activity is lost in Kif21b-knockout neurons. Consistent with a role of the kinesin in regulating actin dynamics, Kif21b overexpression promotes actin polymerization. Moreover, Kif21b controls GKAP removal from spines and the decrease of GluA2-containing AMPARs from the neuronal surface, thereby inducing homeostatic synaptic downscaling. Our data highlight a critical role of Kif21b at the synaptic actin cytoskeleton underlying homeostatic scaling of neuronal firing.

AB - Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic guanylate kinase-associated protein (GKAP) controls the bidirectional synaptic scaling of AMPA receptors (AMPARs); however, mechanisms by which chronic activity triggers cytoskeletal remodeling to downscale synaptic transmission are barely understood. Here, we report that the microtubule-dependent kinesin motor Kif21b binds GKAP and likewise is located in dendritic spines in a myosin Va- and neuronal-activity-dependent manner. Kif21b depletion unexpectedly alters actin dynamics in spines, and adaptation of actin turnover following chronic activity is lost in Kif21b-knockout neurons. Consistent with a role of the kinesin in regulating actin dynamics, Kif21b overexpression promotes actin polymerization. Moreover, Kif21b controls GKAP removal from spines and the decrease of GluA2-containing AMPARs from the neuronal surface, thereby inducing homeostatic synaptic downscaling. Our data highlight a critical role of Kif21b at the synaptic actin cytoskeleton underlying homeostatic scaling of neuronal firing.

KW - Actins/metabolism

KW - Kinesins/metabolism

KW - Neurons/metabolism

KW - Neuronal Plasticity/physiology

KW - Synapses/metabolism

KW - Myosins/metabolism

KW - Dendritic Spines/metabolism

U2 - 10.1016/j.celrep.2023.112743

DO - 10.1016/j.celrep.2023.112743

M3 - SCORING: Journal article

C2 - 37418322

VL - 42

SP - 1

EP - 24

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 7

M1 - 112743

ER -