The isolated mandibular ramus - a hitherto rarely described anomaly of the mandible. Pathogenesis and treatment
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The isolated mandibular ramus - a hitherto rarely described anomaly of the mandible. Pathogenesis and treatment. / Gundlach, Karsten K H; Höltje, Wolf J.
in: J CRANIO MAXILL SURG, Jahrgang 41, Nr. 6, 01.09.2013, S. 450-6.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The isolated mandibular ramus - a hitherto rarely described anomaly of the mandible. Pathogenesis and treatment
AU - Gundlach, Karsten K H
AU - Höltje, Wolf J
N1 - Copyright © 2012 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
PY - 2013/9/1
Y1 - 2013/9/1
N2 - INTRODUCTION: A very famous paper by Sam Pruzansky, published in 1969, was entitled "Not all dwarfed mandibles are alike". This is the topic of this paper: to describe the shape and discuss the possible pathogenesis of an extremely rare congenital dysplasia found in a unilaterally hypoplastic mandible, namely the isolated mandibular ramus.MATERIAL AND METHODS: A unique malformation of the lower jaw was found in more than 75 patients with developmental abnormalities of the mandible diagnosed and treated by the two authors in two different university hospitals over the last 40 years. We performed the following teratological experiments with laboratory rodents in order to try to understand the pathogenesis of this special dysplasia (and others): at first the normal development of the lower jaw was studied in rat and mouse foetuses. Then a variety of teratogenic drugs were applied to pregnant females and then the foetuses of these pregnancies were studied following Caesarian section.RESULTS: One rat foetus was identified which presented the identical dysplasia that had been noted in the patient described here. The dam pregnant with this foetus had been given 25 mg/kg bodyweight of 6-mercaptopurine on day 12 of pregnancy. The explanation found for the pathogenesis of this anomaly was deducted from the scientific literature regarding normal development of the mandibular condyle.CONCLUSION: The nucleus of the so-called secondary cartilage that will produce the ascending ramus (plus condyle and coronoid) is a separate growth centre which fuses a short time later with the dental bone which becomes the mandible proper by this fusion.
AB - INTRODUCTION: A very famous paper by Sam Pruzansky, published in 1969, was entitled "Not all dwarfed mandibles are alike". This is the topic of this paper: to describe the shape and discuss the possible pathogenesis of an extremely rare congenital dysplasia found in a unilaterally hypoplastic mandible, namely the isolated mandibular ramus.MATERIAL AND METHODS: A unique malformation of the lower jaw was found in more than 75 patients with developmental abnormalities of the mandible diagnosed and treated by the two authors in two different university hospitals over the last 40 years. We performed the following teratological experiments with laboratory rodents in order to try to understand the pathogenesis of this special dysplasia (and others): at first the normal development of the lower jaw was studied in rat and mouse foetuses. Then a variety of teratogenic drugs were applied to pregnant females and then the foetuses of these pregnancies were studied following Caesarian section.RESULTS: One rat foetus was identified which presented the identical dysplasia that had been noted in the patient described here. The dam pregnant with this foetus had been given 25 mg/kg bodyweight of 6-mercaptopurine on day 12 of pregnancy. The explanation found for the pathogenesis of this anomaly was deducted from the scientific literature regarding normal development of the mandibular condyle.CONCLUSION: The nucleus of the so-called secondary cartilage that will produce the ascending ramus (plus condyle and coronoid) is a separate growth centre which fuses a short time later with the dental bone which becomes the mandible proper by this fusion.
KW - 6-Mercaptopurine
KW - Animals
KW - Antimetabolites
KW - Autografts
KW - Bone Diseases, Developmental
KW - Bone Transplantation
KW - Cartilage
KW - Child, Preschool
KW - Disease Models, Animal
KW - Dysostoses
KW - Female
KW - Follow-Up Studies
KW - Goldenhar Syndrome
KW - Humans
KW - Mandible
KW - Mandibular Condyle
KW - Mandibular Reconstruction
KW - Mandibulofacial Dysostosis
KW - Mice
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
KW - Rats
KW - Rats, Sprague-Dawley
KW - Teratogens
U2 - 10.1016/j.jcms.2012.11.025
DO - 10.1016/j.jcms.2012.11.025
M3 - SCORING: Journal article
C2 - 23290272
VL - 41
SP - 450
EP - 456
JO - J CRANIO MAXILL SURG
JF - J CRANIO MAXILL SURG
SN - 1010-5182
IS - 6
ER -