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The Intertwining of Autophagy and the Ubiquitin Proteasome System in Podocyte (Patho)Physiology

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The Intertwining of Autophagy and the Ubiquitin Proteasome System in Podocyte (Patho)Physiology. / Heintz, Lukas; Meyer-Schwesinger, Catherine.

in: CELL PHYSIOL BIOCHEM, Jahrgang 55, Nr. S4, 15.09.2021, S. 68-95.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Heintz, L & Meyer-Schwesinger, C 2021, 'The Intertwining of Autophagy and the Ubiquitin Proteasome System in Podocyte (Patho)Physiology', CELL PHYSIOL BIOCHEM, Jg. 55, Nr. S4, S. 68-95. https://doi.org/10.33594/000000432

APA

Heintz, L., & Meyer-Schwesinger, C. (2021). The Intertwining of Autophagy and the Ubiquitin Proteasome System in Podocyte (Patho)Physiology. CELL PHYSIOL BIOCHEM, 55(S4), 68-95. https://doi.org/10.33594/000000432

Vancouver

Heintz L, Meyer-Schwesinger C. The Intertwining of Autophagy and the Ubiquitin Proteasome System in Podocyte (Patho)Physiology. CELL PHYSIOL BIOCHEM. 2021 Sep 15;55(S4):68-95. https://doi.org/10.33594/000000432

Bibtex

@article{8e247ce588004cc2848ed439eab6ec4d,
title = "The Intertwining of Autophagy and the Ubiquitin Proteasome System in Podocyte (Patho)Physiology",
abstract = "Protein homeostasis strongly depends on the targeted and selective removal of unneeded or flawed proteins, of protein aggregates, and of damaged or excess organelles by the two main intracellular degradative systems, namely the ubiquitin proteasomal system (UPS) and the autophagosomal lysosomal system. Despite representing completely distinct mechanisms of degradation, which underlie differing regulatory mechanisms, growing evidence suggests that the UPS and autophagy strongly interact especially in situations of overwhelming and impairment, and that both are involved in podocyte proteostasis and in the pathogenesis of podocyte injury. The differential impact of autophagy and the UPS on podocyte biology and on podocyte disease development and progression is not understood. Recent advances in understanding the role of the UPS and autophagy in podocyte biology are reviewed here.",
keywords = "Animals, Autophagosomes/metabolism, Autophagy, Humans, Kidney Diseases/metabolism, Lysosomes/metabolism, Podocytes/metabolism, Proteasome Endopeptidase Complex/metabolism, Ubiquitin/metabolism",
author = "Lukas Heintz and Catherine Meyer-Schwesinger",
note = "{\textcopyright} Copyright by the Author(s). Published by Cell Physiol Biochem Press.",
year = "2021",
month = sep,
day = "15",
doi = "10.33594/000000432",
language = "English",
volume = "55",
pages = "68--95",
journal = "CELL PHYSIOL BIOCHEM",
issn = "1015-8987",
publisher = "S. Karger AG",
number = "S4",

}

RIS

TY - JOUR

T1 - The Intertwining of Autophagy and the Ubiquitin Proteasome System in Podocyte (Patho)Physiology

AU - Heintz, Lukas

AU - Meyer-Schwesinger, Catherine

N1 - © Copyright by the Author(s). Published by Cell Physiol Biochem Press.

PY - 2021/9/15

Y1 - 2021/9/15

N2 - Protein homeostasis strongly depends on the targeted and selective removal of unneeded or flawed proteins, of protein aggregates, and of damaged or excess organelles by the two main intracellular degradative systems, namely the ubiquitin proteasomal system (UPS) and the autophagosomal lysosomal system. Despite representing completely distinct mechanisms of degradation, which underlie differing regulatory mechanisms, growing evidence suggests that the UPS and autophagy strongly interact especially in situations of overwhelming and impairment, and that both are involved in podocyte proteostasis and in the pathogenesis of podocyte injury. The differential impact of autophagy and the UPS on podocyte biology and on podocyte disease development and progression is not understood. Recent advances in understanding the role of the UPS and autophagy in podocyte biology are reviewed here.

AB - Protein homeostasis strongly depends on the targeted and selective removal of unneeded or flawed proteins, of protein aggregates, and of damaged or excess organelles by the two main intracellular degradative systems, namely the ubiquitin proteasomal system (UPS) and the autophagosomal lysosomal system. Despite representing completely distinct mechanisms of degradation, which underlie differing regulatory mechanisms, growing evidence suggests that the UPS and autophagy strongly interact especially in situations of overwhelming and impairment, and that both are involved in podocyte proteostasis and in the pathogenesis of podocyte injury. The differential impact of autophagy and the UPS on podocyte biology and on podocyte disease development and progression is not understood. Recent advances in understanding the role of the UPS and autophagy in podocyte biology are reviewed here.

KW - Animals

KW - Autophagosomes/metabolism

KW - Autophagy

KW - Humans

KW - Kidney Diseases/metabolism

KW - Lysosomes/metabolism

KW - Podocytes/metabolism

KW - Proteasome Endopeptidase Complex/metabolism

KW - Ubiquitin/metabolism

U2 - 10.33594/000000432

DO - 10.33594/000000432

M3 - SCORING: Review article

C2 - 34523304

VL - 55

SP - 68

EP - 95

JO - CELL PHYSIOL BIOCHEM

JF - CELL PHYSIOL BIOCHEM

SN - 1015-8987

IS - S4

ER -