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The inhibitor of apoptosis (IAP) survivin is expressed in human testicular germ cell tumors and normal testes.

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The inhibitor of apoptosis (IAP) survivin is expressed in human testicular germ cell tumors and normal testes. / Weikert, Steffen; Schrader, Mark; Krause, Hans; Schulze, Wolfgang; Müller, Markus; Miller, Kurt.

in: CANCER LETT, Jahrgang 223, Nr. 2, 2, 2005, S. 331-337.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Weikert, S, Schrader, M, Krause, H, Schulze, W, Müller, M & Miller, K 2005, 'The inhibitor of apoptosis (IAP) survivin is expressed in human testicular germ cell tumors and normal testes.', CANCER LETT, Jg. 223, Nr. 2, 2, S. 331-337. <http://www.ncbi.nlm.nih.gov/pubmed/15896468?dopt=Citation>

APA

Weikert, S., Schrader, M., Krause, H., Schulze, W., Müller, M., & Miller, K. (2005). The inhibitor of apoptosis (IAP) survivin is expressed in human testicular germ cell tumors and normal testes. CANCER LETT, 223(2), 331-337. [2]. http://www.ncbi.nlm.nih.gov/pubmed/15896468?dopt=Citation

Vancouver

Weikert S, Schrader M, Krause H, Schulze W, Müller M, Miller K. The inhibitor of apoptosis (IAP) survivin is expressed in human testicular germ cell tumors and normal testes. CANCER LETT. 2005;223(2):331-337. 2.

Bibtex

@article{54bc6ddaa38f4e378a5947ff406b00bd,
title = "The inhibitor of apoptosis (IAP) survivin is expressed in human testicular germ cell tumors and normal testes.",
abstract = "Deregulated apoptosis of germ cells may contribute to malignant transformation as well as male infertility. We analyzed expression of the inhibitor of apoptosis survivin by polymerase chain reaction (PCR) in testicular germ cell tumors (TGCTs, n=28), normal testes (n=19) and testes with defective spermatogenesis (n=22). In a subset of samples (n=35), survivin transcript levels were quantified using real-time PCR. While survivin mRNA was expressed at high levels in undifferentiated TGCTs and normal testes, it was lost in mature teratomas and germ cell aplasia. Survivin expression in both normal and transformed germ cells is in contrast to its sharp differential expression in other tissues. Survivin expression correlates with the differentiation state of TGCTs and may be relevant for their tumorigenesis and malignant potential.",
author = "Steffen Weikert and Mark Schrader and Hans Krause and Wolfgang Schulze and Markus M{\"u}ller and Kurt Miller",
year = "2005",
language = "Deutsch",
volume = "223",
pages = "331--337",
journal = "CANCER LETT",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - The inhibitor of apoptosis (IAP) survivin is expressed in human testicular germ cell tumors and normal testes.

AU - Weikert, Steffen

AU - Schrader, Mark

AU - Krause, Hans

AU - Schulze, Wolfgang

AU - Müller, Markus

AU - Miller, Kurt

PY - 2005

Y1 - 2005

N2 - Deregulated apoptosis of germ cells may contribute to malignant transformation as well as male infertility. We analyzed expression of the inhibitor of apoptosis survivin by polymerase chain reaction (PCR) in testicular germ cell tumors (TGCTs, n=28), normal testes (n=19) and testes with defective spermatogenesis (n=22). In a subset of samples (n=35), survivin transcript levels were quantified using real-time PCR. While survivin mRNA was expressed at high levels in undifferentiated TGCTs and normal testes, it was lost in mature teratomas and germ cell aplasia. Survivin expression in both normal and transformed germ cells is in contrast to its sharp differential expression in other tissues. Survivin expression correlates with the differentiation state of TGCTs and may be relevant for their tumorigenesis and malignant potential.

AB - Deregulated apoptosis of germ cells may contribute to malignant transformation as well as male infertility. We analyzed expression of the inhibitor of apoptosis survivin by polymerase chain reaction (PCR) in testicular germ cell tumors (TGCTs, n=28), normal testes (n=19) and testes with defective spermatogenesis (n=22). In a subset of samples (n=35), survivin transcript levels were quantified using real-time PCR. While survivin mRNA was expressed at high levels in undifferentiated TGCTs and normal testes, it was lost in mature teratomas and germ cell aplasia. Survivin expression in both normal and transformed germ cells is in contrast to its sharp differential expression in other tissues. Survivin expression correlates with the differentiation state of TGCTs and may be relevant for their tumorigenesis and malignant potential.

M3 - SCORING: Zeitschriftenaufsatz

VL - 223

SP - 331

EP - 337

JO - CANCER LETT

JF - CANCER LETT

SN - 0304-3835

IS - 2

M1 - 2

ER -