The hypothalamic-pituitary-adrenocortical system and sleep in man.
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The hypothalamic-pituitary-adrenocortical system and sleep in man. / Friess, E; Wiedemann, Klaus; Steiger, A; Holsboer, F.
in: Adv Neuroimmunol, Jahrgang 5, Nr. 2, 2, 1995, S. 111-125.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The hypothalamic-pituitary-adrenocortical system and sleep in man.
AU - Friess, E
AU - Wiedemann, Klaus
AU - Steiger, A
AU - Holsboer, F
PY - 1995
Y1 - 1995
N2 - This review article summarizes the major findings about the interactions of human sleep structure and the hypothalamo-pituitary-adrenocortical (HPA) system under physiological and pathophysiological conditions, including studies that probe the sleep effects of systemically administered HPA hormones. Human sleep is regulated by a concerted action of various signal compounds acting at sleep-generating neurons whose central organization is not yet fully understood. During nocturnal sleep the endocrine system is remarkably active, the longest established finding being that growth hormone (GH) release is associated with the initiation of sleep and that there is a steep morning rise of cortisol (Weitzman et al., 1966; Takahashi et al., 1968). Moreover, the effects of exogenously administered corticosteroids and of their excessive endogenous release (e.g. Cushing's disease) were recognized more than 20 years ago.
AB - This review article summarizes the major findings about the interactions of human sleep structure and the hypothalamo-pituitary-adrenocortical (HPA) system under physiological and pathophysiological conditions, including studies that probe the sleep effects of systemically administered HPA hormones. Human sleep is regulated by a concerted action of various signal compounds acting at sleep-generating neurons whose central organization is not yet fully understood. During nocturnal sleep the endocrine system is remarkably active, the longest established finding being that growth hormone (GH) release is associated with the initiation of sleep and that there is a steep morning rise of cortisol (Weitzman et al., 1966; Takahashi et al., 1968). Moreover, the effects of exogenously administered corticosteroids and of their excessive endogenous release (e.g. Cushing's disease) were recognized more than 20 years ago.
M3 - SCORING: Zeitschriftenaufsatz
VL - 5
SP - 111
EP - 125
IS - 2
M1 - 2
ER -
