PortalPublikationenThe HMGB1 protein induces a metabolic type of tumour cell de...

The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration

Standard

The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. / Gdynia, Georg; Sauer, Sven W; Kopitz, Jürgen; Fuchs, Dominik; Duglova, Katarina; Ruppert, Thorsten; Miller, Matthias; Pahl, Jens; Cerwenka, Adelheid; Enders, Markus; Mairbäurl, Heimo; Kamiński, Marcin M; Penzel, Roland; Zhang, Christine; Fuller, Jonathan C; Wade, Rebecca C; Benner, Axel; Chang-Claude, Jenny; Brenner, Hermann; Hoffmeister, Michael; Zentgraf, Hanswalter; Schirmacher, Peter; Roth, Wilfried.

in: NAT COMMUN, Jahrgang 7, 07.03.2016, S. 10764.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gdynia, G, Sauer, SW, Kopitz, J, Fuchs, D, Duglova, K, Ruppert, T, Miller, M, Pahl, J, Cerwenka, A, Enders, M, Mairbäurl, H, Kamiński, MM, Penzel, R, Zhang, C, Fuller, JC, Wade, RC, Benner, A, Chang-Claude, J, Brenner, H, Hoffmeister, M, Zentgraf, H, Schirmacher, P & Roth, W 2016, 'The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration', NAT COMMUN, Jg. 7, S. 10764. https://doi.org/10.1038/ncomms10764

APA

Gdynia, G., Sauer, S. W., Kopitz, J., Fuchs, D., Duglova, K., Ruppert, T., Miller, M., Pahl, J., Cerwenka, A., Enders, M., Mairbäurl, H., Kamiński, M. M., Penzel, R., Zhang, C., Fuller, J. C., Wade, R. C., Benner, A., Chang-Claude, J., Brenner, H., ... Roth, W. (2016). The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. NAT COMMUN, 7, 10764. https://doi.org/10.1038/ncomms10764

Vancouver

Gdynia G, Sauer SW, Kopitz J, Fuchs D, Duglova K, Ruppert T et al. The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. NAT COMMUN. 2016 Mär 7;7:10764. https://doi.org/10.1038/ncomms10764

Bibtex

@article{ab28a8f3eb7b440fa0f4bbb52066d486,
title = "The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration",
abstract = "The high-mobility group box 1 (HMGB1) protein has a central role in immunological antitumour defense. Here we show that natural killer cell-derived HMGB1 directly eliminates cancer cells by triggering metabolic cell death. HMGB1 allosterically inhibits the tetrameric pyruvate kinase isoform M2, thus blocking glucose-driven aerobic respiration. This results in a rapid metabolic shift forcing cells to rely solely on glycolysis for the maintenance of energy production. Cancer cells can acquire resistance to HMGB1 by increasing glycolysis using the dimeric form of PKM2, and employing glutaminolysis. Consistently, we observe an increase in the expression of a key enzyme of glutaminolysis, malic enzyme 1, in advanced colon cancer. Moreover, pharmaceutical inhibition of glutaminolysis sensitizes tumour cells to HMGB1 providing a basis for a therapeutic strategy for treating cancer.",
author = "Georg Gdynia and Sauer, {Sven W} and J{\"u}rgen Kopitz and Dominik Fuchs and Katarina Duglova and Thorsten Ruppert and Matthias Miller and Jens Pahl and Adelheid Cerwenka and Markus Enders and Heimo Mairb{\"a}url and Kami{\'n}ski, {Marcin M} and Roland Penzel and Christine Zhang and Fuller, {Jonathan C} and Wade, {Rebecca C} and Axel Benner and Jenny Chang-Claude and Hermann Brenner and Michael Hoffmeister and Hanswalter Zentgraf and Peter Schirmacher and Wilfried Roth",
year = "2016",
month = mar,
day = "7",
doi = "10.1038/ncomms10764",
language = "English",
volume = "7",
pages = "10764",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration

AU - Gdynia, Georg

AU - Sauer, Sven W

AU - Kopitz, Jürgen

AU - Fuchs, Dominik

AU - Duglova, Katarina

AU - Ruppert, Thorsten

AU - Miller, Matthias

AU - Pahl, Jens

AU - Cerwenka, Adelheid

AU - Enders, Markus

AU - Mairbäurl, Heimo

AU - Kamiński, Marcin M

AU - Penzel, Roland

AU - Zhang, Christine

AU - Fuller, Jonathan C

AU - Wade, Rebecca C

AU - Benner, Axel

AU - Chang-Claude, Jenny

AU - Brenner, Hermann

AU - Hoffmeister, Michael

AU - Zentgraf, Hanswalter

AU - Schirmacher, Peter

AU - Roth, Wilfried

PY - 2016/3/7

Y1 - 2016/3/7

N2 - The high-mobility group box 1 (HMGB1) protein has a central role in immunological antitumour defense. Here we show that natural killer cell-derived HMGB1 directly eliminates cancer cells by triggering metabolic cell death. HMGB1 allosterically inhibits the tetrameric pyruvate kinase isoform M2, thus blocking glucose-driven aerobic respiration. This results in a rapid metabolic shift forcing cells to rely solely on glycolysis for the maintenance of energy production. Cancer cells can acquire resistance to HMGB1 by increasing glycolysis using the dimeric form of PKM2, and employing glutaminolysis. Consistently, we observe an increase in the expression of a key enzyme of glutaminolysis, malic enzyme 1, in advanced colon cancer. Moreover, pharmaceutical inhibition of glutaminolysis sensitizes tumour cells to HMGB1 providing a basis for a therapeutic strategy for treating cancer.

AB - The high-mobility group box 1 (HMGB1) protein has a central role in immunological antitumour defense. Here we show that natural killer cell-derived HMGB1 directly eliminates cancer cells by triggering metabolic cell death. HMGB1 allosterically inhibits the tetrameric pyruvate kinase isoform M2, thus blocking glucose-driven aerobic respiration. This results in a rapid metabolic shift forcing cells to rely solely on glycolysis for the maintenance of energy production. Cancer cells can acquire resistance to HMGB1 by increasing glycolysis using the dimeric form of PKM2, and employing glutaminolysis. Consistently, we observe an increase in the expression of a key enzyme of glutaminolysis, malic enzyme 1, in advanced colon cancer. Moreover, pharmaceutical inhibition of glutaminolysis sensitizes tumour cells to HMGB1 providing a basis for a therapeutic strategy for treating cancer.

U2 - 10.1038/ncomms10764

DO - 10.1038/ncomms10764

M3 - SCORING: Journal article

C2 - 26948869

VL - 7

SP - 10764

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -