The guinea pig model in cardiac regeneration research. Current tissue engineering approaches and future directions
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The guinea pig model in cardiac regeneration research. Current tissue engineering approaches and future directions. / Stüdemann, Tim; Weinberger, Florian.
Advanced Technologies in Cardiovascular Bioengineering. Hrsg. / Jianyi Zhang; Vahid Serpooshan. 1. Aufl. Springer International Publishing, 2022. S. 103-122.Publikationen: SCORING: Beitrag in Buch/Sammelwerk › SCORING: Beitrag in Sammelwerk › Forschung
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TY - CHAP
T1 - The guinea pig model in cardiac regeneration research. Current tissue engineering approaches and future directions
AU - Stüdemann, Tim
AU - Weinberger, Florian
PY - 2022/3/10
Y1 - 2022/3/10
N2 - Cardiovascular disease represents a major disease burden. Modern pharmacotherapy, in combination with interventional and surgical approaches, has substantially improved life expectancy for many patients. Yet, current therapies are not able to solve a causal problem, the loss of cardiomyocytes. Regenerative approaches with pluripotent stem cell-derived cardiomyocytes (PSC-CMs) have shown the ability to remuscularize the injured heart in various preclinical models. In this chapter, we summarize tissue engineering approaches and discuss the use of the cryoinjury guinea pig model for preclinical studies.
AB - Cardiovascular disease represents a major disease burden. Modern pharmacotherapy, in combination with interventional and surgical approaches, has substantially improved life expectancy for many patients. Yet, current therapies are not able to solve a causal problem, the loss of cardiomyocytes. Regenerative approaches with pluripotent stem cell-derived cardiomyocytes (PSC-CMs) have shown the ability to remuscularize the injured heart in various preclinical models. In this chapter, we summarize tissue engineering approaches and discuss the use of the cryoinjury guinea pig model for preclinical studies.
U2 - 10.1007/978-3-030-86140-7_7
DO - 10.1007/978-3-030-86140-7_7
M3 - SCORING: Contribution to collected editions/anthologies
SN - 978-3-030-86139-1
SP - 103
EP - 122
BT - Advanced Technologies in Cardiovascular Bioengineering
A2 - Zhang, Jianyi
A2 - Serpooshan, Vahid
PB - Springer International Publishing
ER -