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The Fos family of transcription factors and their role in tumourigenesis

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The Fos family of transcription factors and their role in tumourigenesis. / Milde-Langosch, Karin.

in: EUR J CANCER, Jahrgang 41, Nr. 16, 11.2005, S. 2449-61.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Milde-Langosch, K 2005, 'The Fos family of transcription factors and their role in tumourigenesis', EUR J CANCER, Jg. 41, Nr. 16, S. 2449-61. https://doi.org/10.1016/j.ejca.2005.08.008

APA

Milde-Langosch, K. (2005). The Fos family of transcription factors and their role in tumourigenesis. EUR J CANCER, 41(16), 2449-61. https://doi.org/10.1016/j.ejca.2005.08.008

Vancouver

Milde-Langosch K. The Fos family of transcription factors and their role in tumourigenesis. EUR J CANCER. 2005 Nov;41(16):2449-61. https://doi.org/10.1016/j.ejca.2005.08.008

Bibtex

@article{c37086aed26e4225b446c78d0362fcb4,
title = "The Fos family of transcription factors and their role in tumourigenesis",
abstract = "Members of the Fos family (c-Fos, FosB and its smaller splice variants, Fra-1 and Fra-2) dimerise with Jun proteins to form the AP-1 transcription factor complex. Based on the rapidly growing amount of data from experimental studies, animal models and investigations on clinical tumour samples, this review summarises the current knowledge about the role of these proteins in carcinogenesis. In addition to c-Fos, which has oncogenic activity and is frequently overexpressed in tumour cells, Fra-1 seems to play a role in the progression of many carcinomas. The results obtained from various studies show different implications for these transcription factors according to tumour type, i.e., Fra-1 overexpression enhances the motility and invasion of breast and colorectal cancer cells, but inhibits the tumourigenicity of cervical carcinoma cell lines. Knowledge about regulation of invasion and metastasis in different malignant tumours in vivo might open promising perspectives to targeted therapeutic approaches.",
keywords = "Genes, fos, Humans, Neoplasms, Transcription Factor AP-1, Transcription Factors",
author = "Karin Milde-Langosch",
year = "2005",
month = nov,
doi = "10.1016/j.ejca.2005.08.008",
language = "English",
volume = "41",
pages = "2449--61",
journal = "EUR J CANCER",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "16",

}

RIS

TY - JOUR

T1 - The Fos family of transcription factors and their role in tumourigenesis

AU - Milde-Langosch, Karin

PY - 2005/11

Y1 - 2005/11

N2 - Members of the Fos family (c-Fos, FosB and its smaller splice variants, Fra-1 and Fra-2) dimerise with Jun proteins to form the AP-1 transcription factor complex. Based on the rapidly growing amount of data from experimental studies, animal models and investigations on clinical tumour samples, this review summarises the current knowledge about the role of these proteins in carcinogenesis. In addition to c-Fos, which has oncogenic activity and is frequently overexpressed in tumour cells, Fra-1 seems to play a role in the progression of many carcinomas. The results obtained from various studies show different implications for these transcription factors according to tumour type, i.e., Fra-1 overexpression enhances the motility and invasion of breast and colorectal cancer cells, but inhibits the tumourigenicity of cervical carcinoma cell lines. Knowledge about regulation of invasion and metastasis in different malignant tumours in vivo might open promising perspectives to targeted therapeutic approaches.

AB - Members of the Fos family (c-Fos, FosB and its smaller splice variants, Fra-1 and Fra-2) dimerise with Jun proteins to form the AP-1 transcription factor complex. Based on the rapidly growing amount of data from experimental studies, animal models and investigations on clinical tumour samples, this review summarises the current knowledge about the role of these proteins in carcinogenesis. In addition to c-Fos, which has oncogenic activity and is frequently overexpressed in tumour cells, Fra-1 seems to play a role in the progression of many carcinomas. The results obtained from various studies show different implications for these transcription factors according to tumour type, i.e., Fra-1 overexpression enhances the motility and invasion of breast and colorectal cancer cells, but inhibits the tumourigenicity of cervical carcinoma cell lines. Knowledge about regulation of invasion and metastasis in different malignant tumours in vivo might open promising perspectives to targeted therapeutic approaches.

KW - Genes, fos

KW - Humans

KW - Neoplasms

KW - Transcription Factor AP-1

KW - Transcription Factors

U2 - 10.1016/j.ejca.2005.08.008

DO - 10.1016/j.ejca.2005.08.008

M3 - SCORING: Journal article

C2 - 16199154

VL - 41

SP - 2449

EP - 2461

JO - EUR J CANCER

JF - EUR J CANCER

SN - 0959-8049

IS - 16

ER -