The evolving classification of von Willebrand disease
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The evolving classification of von Willebrand disease. / Schneppenheim, Reinhard.
in: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Jahrgang 16 Suppl 1, 01.04.2005, S. S3-S10.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The evolving classification of von Willebrand disease
AU - Schneppenheim, Reinhard
PY - 2005/4/1
Y1 - 2005/4/1
N2 - The classification of von Willebrand disease (VWD) has been refined since its first description in the 1920s, as knowledge regarding clinical symptoms and tests of von Willebrand factor (VWF) activity and multimer composition have increased. Current molecular approaches have allowed better understanding of the biosynthesis and function of VWF, and made possible phenotype-genotype studies of VWD subtypes. Improved classification of this heterogeneous disorder based on reproducible correlations between specific genetic mutations and recognized phenotypes should aid in determining appropriate management of patients with VWD.
AB - The classification of von Willebrand disease (VWD) has been refined since its first description in the 1920s, as knowledge regarding clinical symptoms and tests of von Willebrand factor (VWF) activity and multimer composition have increased. Current molecular approaches have allowed better understanding of the biosynthesis and function of VWF, and made possible phenotype-genotype studies of VWD subtypes. Improved classification of this heterogeneous disorder based on reproducible correlations between specific genetic mutations and recognized phenotypes should aid in determining appropriate management of patients with VWD.
KW - Classification
KW - Dimerization
KW - Gene Components
KW - History, 20th Century
KW - History, 21st Century
KW - Humans
KW - von Willebrand Diseases
M3 - SCORING: Journal article
C2 - 15849525
VL - 16 Suppl 1
SP - S3-S10
JO - BLOOD COAGUL FIBRIN
JF - BLOOD COAGUL FIBRIN
SN - 0957-5235
ER -