The endoplasmic reticulum puts a new spin on synaptic tagging

Anja Konietzny; Susanne Wegmann; Marina Mikhaylova

doi:10.1016/j.tins.2022.10.012

The endoplasmic reticulum puts a new spin on synaptic tagging

Standard

The endoplasmic reticulum puts a new spin on synaptic tagging. / Konietzny, Anja; Wegmann, Susanne; Mikhaylova, Marina.

in: TRENDS NEUROSCI, Jahrgang 46, Nr. 1, 01.2023, S. 32-44.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Konietzny, A, Wegmann, S & Mikhaylova, M 2023, 'The endoplasmic reticulum puts a new spin on synaptic tagging', TRENDS NEUROSCI, Jg. 46, Nr. 1, S. 32-44. https://doi.org/10.1016/j.tins.2022.10.012

APA

Konietzny, A., Wegmann, S., & Mikhaylova, M. (2023). The endoplasmic reticulum puts a new spin on synaptic tagging. TRENDS NEUROSCI, 46(1), 32-44. https://doi.org/10.1016/j.tins.2022.10.012

Vancouver

Konietzny A, Wegmann S, Mikhaylova M. The endoplasmic reticulum puts a new spin on synaptic tagging. TRENDS NEUROSCI. 2023 Jan;46(1):32-44. https://doi.org/10.1016/j.tins.2022.10.012

Bibtex

@article{9144f33cbdd843b0bb7921a1207ce958,

title = "The endoplasmic reticulum puts a new spin on synaptic tagging",

abstract = "The heterogeneity of the endoplasmic reticulum (ER) makes it a versatile platform for a broad range of homeostatic processes, ranging from calcium regulation to synthesis and trafficking of proteins and lipids. It is not surprising that neurons use this organelle to fine-tune synaptic properties and thereby provide specificity to synaptic inputs. In this review, we discuss the mechanisms that enable activity-dependent ER recruitment into dendritic spines, with a focus on molecular mechanisms that mediate transport and retention of the ER in spines. The role of calcium signaling in spine ER, synaptopodin 'tagging' of active synapses, and the formation of the spine apparatus (SA) are highlighted. Finally, we discuss the role of liquid-liquid phase separation as a possible driving force in these processes.",

author = "Anja Konietzny and Susanne Wegmann and Marina Mikhaylova",

year = "2023",

month = jan,

doi = "10.1016/j.tins.2022.10.012",

language = "English",

volume = "46",

pages = "32--44",

journal = "TRENDS NEUROSCI",

issn = "0166-2236",

publisher = "Elsevier Limited",

number = "1",

}

RIS

TY - JOUR

T1 - The endoplasmic reticulum puts a new spin on synaptic tagging

AU - Konietzny, Anja

AU - Wegmann, Susanne

AU - Mikhaylova, Marina

PY - 2023/1

Y1 - 2023/1

N2 - The heterogeneity of the endoplasmic reticulum (ER) makes it a versatile platform for a broad range of homeostatic processes, ranging from calcium regulation to synthesis and trafficking of proteins and lipids. It is not surprising that neurons use this organelle to fine-tune synaptic properties and thereby provide specificity to synaptic inputs. In this review, we discuss the mechanisms that enable activity-dependent ER recruitment into dendritic spines, with a focus on molecular mechanisms that mediate transport and retention of the ER in spines. The role of calcium signaling in spine ER, synaptopodin 'tagging' of active synapses, and the formation of the spine apparatus (SA) are highlighted. Finally, we discuss the role of liquid-liquid phase separation as a possible driving force in these processes.

AB - The heterogeneity of the endoplasmic reticulum (ER) makes it a versatile platform for a broad range of homeostatic processes, ranging from calcium regulation to synthesis and trafficking of proteins and lipids. It is not surprising that neurons use this organelle to fine-tune synaptic properties and thereby provide specificity to synaptic inputs. In this review, we discuss the mechanisms that enable activity-dependent ER recruitment into dendritic spines, with a focus on molecular mechanisms that mediate transport and retention of the ER in spines. The role of calcium signaling in spine ER, synaptopodin 'tagging' of active synapses, and the formation of the spine apparatus (SA) are highlighted. Finally, we discuss the role of liquid-liquid phase separation as a possible driving force in these processes.

U2 - 10.1016/j.tins.2022.10.012

DO - 10.1016/j.tins.2022.10.012

M3 - SCORING: Review article

C2 - 36428191

VL - 46

SP - 32

EP - 44

JO - TRENDS NEUROSCI

JF - TRENDS NEUROSCI

SN - 0166-2236

IS - 1

ER -