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The efficiency of humoral immune transfer depends on both the graft and the immunosuppressive treatment

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The efficiency of humoral immune transfer depends on both the graft and the immunosuppressive treatment. / Dahmen, Uta; Li, Jun; Gu, Yi; Doebel, Lothar; Fan, Li Ming; Polywka, Susanne; Dirsch, Olaf; Broelsch, Christoph E.

in: TRANSPL INT, Jahrgang 16, Nr. 3, 03.2003, S. 161-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dahmen, U, Li, J, Gu, Y, Doebel, L, Fan, LM, Polywka, S, Dirsch, O & Broelsch, CE 2003, 'The efficiency of humoral immune transfer depends on both the graft and the immunosuppressive treatment', TRANSPL INT, Jg. 16, Nr. 3, S. 161-7. https://doi.org/10.1007/s00147-002-0518-6

APA

Dahmen, U., Li, J., Gu, Y., Doebel, L., Fan, L. M., Polywka, S., Dirsch, O., & Broelsch, C. E. (2003). The efficiency of humoral immune transfer depends on both the graft and the immunosuppressive treatment. TRANSPL INT, 16(3), 161-7. https://doi.org/10.1007/s00147-002-0518-6

Vancouver

Dahmen U, Li J, Gu Y, Doebel L, Fan LM, Polywka S et al. The efficiency of humoral immune transfer depends on both the graft and the immunosuppressive treatment. TRANSPL INT. 2003 Mär;16(3):161-7. https://doi.org/10.1007/s00147-002-0518-6

Bibtex

@article{af4658c51f6543cf953de44d0f18a339,
title = "The efficiency of humoral immune transfer depends on both the graft and the immunosuppressive treatment",
abstract = "The present study was designed to compare the efficiency of adoptive transfer of humoral immunity after liver, kidney, and heart transplantation in relation to the number of passenger lymphocytes, and to estimate the risk of a detrimental effect and the chance of a beneficial effect. Hepatitis B virus surface-antigen-vaccinated brown Norway rats (BNs) and AxC 9935 Irish (ACI rats) served as donors, and na{\"i}ve Lewis (LEW) rats as recipients. The liver grafts contained 100 times more passenger lymphocytes than heart grafts, and the kidney grafts approximately ten times more, indicated by monoclonal CD45 antibody staining. Transient anti-HBs immunity did occur after transplantation of all three organ grafts. In all rejecting groups, the serum recipient-to-donor anti-HBs titer ratio (R/D ratio) was below 0.10%, with heart recipients showing half the level (0.05%) of liver recipients (0.09%). Under immunosuppression, R/D ratio doubled in liver or kidney recipients, but remained unaffected in heart recipients. Immune transfer was most efficient in immune-suppressed liver recipients in the spontaneously tolerant strain combination as indicated by a significantly higher R/D ratio (0.32%) and a longer titer persistence (up to 9 weeks) than in all other groups. Therefore, mainly liver and kidney graft recipients carry a risk, but also a chance of benefiting from the transfer of donor-derived immunity.",
keywords = "Animals, Antibody Formation, Heart Transplantation, Immunohistochemistry, Immunosuppressive Agents, Intercellular Adhesion Molecule-1, Kidney Transplantation, Liver Transplantation, Rats, Rats, Inbred ACI, Rats, Inbred BN, Rats, Inbred Lew, Transplantation Immunology, Transplantation, Homologous, Comparative Study, Journal Article",
author = "Uta Dahmen and Jun Li and Yi Gu and Lothar Doebel and Fan, {Li Ming} and Susanne Polywka and Olaf Dirsch and Broelsch, {Christoph E}",
year = "2003",
month = mar,
doi = "10.1007/s00147-002-0518-6",
language = "English",
volume = "16",
pages = "161--7",
journal = "TRANSPL INT",
issn = "0934-0874",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - The efficiency of humoral immune transfer depends on both the graft and the immunosuppressive treatment

AU - Dahmen, Uta

AU - Li, Jun

AU - Gu, Yi

AU - Doebel, Lothar

AU - Fan, Li Ming

AU - Polywka, Susanne

AU - Dirsch, Olaf

AU - Broelsch, Christoph E

PY - 2003/3

Y1 - 2003/3

N2 - The present study was designed to compare the efficiency of adoptive transfer of humoral immunity after liver, kidney, and heart transplantation in relation to the number of passenger lymphocytes, and to estimate the risk of a detrimental effect and the chance of a beneficial effect. Hepatitis B virus surface-antigen-vaccinated brown Norway rats (BNs) and AxC 9935 Irish (ACI rats) served as donors, and naïve Lewis (LEW) rats as recipients. The liver grafts contained 100 times more passenger lymphocytes than heart grafts, and the kidney grafts approximately ten times more, indicated by monoclonal CD45 antibody staining. Transient anti-HBs immunity did occur after transplantation of all three organ grafts. In all rejecting groups, the serum recipient-to-donor anti-HBs titer ratio (R/D ratio) was below 0.10%, with heart recipients showing half the level (0.05%) of liver recipients (0.09%). Under immunosuppression, R/D ratio doubled in liver or kidney recipients, but remained unaffected in heart recipients. Immune transfer was most efficient in immune-suppressed liver recipients in the spontaneously tolerant strain combination as indicated by a significantly higher R/D ratio (0.32%) and a longer titer persistence (up to 9 weeks) than in all other groups. Therefore, mainly liver and kidney graft recipients carry a risk, but also a chance of benefiting from the transfer of donor-derived immunity.

AB - The present study was designed to compare the efficiency of adoptive transfer of humoral immunity after liver, kidney, and heart transplantation in relation to the number of passenger lymphocytes, and to estimate the risk of a detrimental effect and the chance of a beneficial effect. Hepatitis B virus surface-antigen-vaccinated brown Norway rats (BNs) and AxC 9935 Irish (ACI rats) served as donors, and naïve Lewis (LEW) rats as recipients. The liver grafts contained 100 times more passenger lymphocytes than heart grafts, and the kidney grafts approximately ten times more, indicated by monoclonal CD45 antibody staining. Transient anti-HBs immunity did occur after transplantation of all three organ grafts. In all rejecting groups, the serum recipient-to-donor anti-HBs titer ratio (R/D ratio) was below 0.10%, with heart recipients showing half the level (0.05%) of liver recipients (0.09%). Under immunosuppression, R/D ratio doubled in liver or kidney recipients, but remained unaffected in heart recipients. Immune transfer was most efficient in immune-suppressed liver recipients in the spontaneously tolerant strain combination as indicated by a significantly higher R/D ratio (0.32%) and a longer titer persistence (up to 9 weeks) than in all other groups. Therefore, mainly liver and kidney graft recipients carry a risk, but also a chance of benefiting from the transfer of donor-derived immunity.

KW - Animals

KW - Antibody Formation

KW - Heart Transplantation

KW - Immunohistochemistry

KW - Immunosuppressive Agents

KW - Intercellular Adhesion Molecule-1

KW - Kidney Transplantation

KW - Liver Transplantation

KW - Rats

KW - Rats, Inbred ACI

KW - Rats, Inbred BN

KW - Rats, Inbred Lew

KW - Transplantation Immunology

KW - Transplantation, Homologous

KW - Comparative Study

KW - Journal Article

U2 - 10.1007/s00147-002-0518-6

DO - 10.1007/s00147-002-0518-6

M3 - SCORING: Journal article

C2 - 12664210

VL - 16

SP - 161

EP - 167

JO - TRANSPL INT

JF - TRANSPL INT

SN - 0934-0874

IS - 3

ER -