[The effect of the time interval between fractions on the result of a fractionated irradiation of the R1H tumor]
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[The effect of the time interval between fractions on the result of a fractionated irradiation of the R1H tumor]. / Beck-Bornholdt, Hans-Peter; Kleineidam, M; Pieconka, A.
in: STRAHLENTHER ONKOL, Jahrgang 170, Nr. 4, 4, 1994, S. 232-234.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - [The effect of the time interval between fractions on the result of a fractionated irradiation of the R1H tumor]
AU - Beck-Bornholdt, Hans-Peter
AU - Kleineidam, M
AU - Pieconka, A
PY - 1994
Y1 - 1994
N2 - BACKGROUND: The response of an experimental tumor to hyperfractionated irradiation with different time intervals between the two daily fractions has been investigated. MATERIAL AND METHODS: Tumors were exposed to irradiation five days per week over six weeks. A standard treatment of 30 fractions, i.e. one fraction per day (200 kVp X-rays) was compared with a hyperfractionated schedule of 60 fractions, i.e. two fractions per day, with time intervals of either one, two, three, five or six hours between the two daily fractions. RESULTS: Compared with standard treatment a significant reduction (p <0.005) of net growth delay was observed for the tumors treated with two daily fractions separated by two hours. However, at a time interval of five and six hours between the two daily fractions net growth delay increased considerably (p <0.0001 and p <0.01) as compared with the standard treatment. CONCLUSION: Our results indicate the importance of the time interval between the daily fractions in hyperfractionated and accelerated radiotherapy.
AB - BACKGROUND: The response of an experimental tumor to hyperfractionated irradiation with different time intervals between the two daily fractions has been investigated. MATERIAL AND METHODS: Tumors were exposed to irradiation five days per week over six weeks. A standard treatment of 30 fractions, i.e. one fraction per day (200 kVp X-rays) was compared with a hyperfractionated schedule of 60 fractions, i.e. two fractions per day, with time intervals of either one, two, three, five or six hours between the two daily fractions. RESULTS: Compared with standard treatment a significant reduction (p <0.005) of net growth delay was observed for the tumors treated with two daily fractions separated by two hours. However, at a time interval of five and six hours between the two daily fractions net growth delay increased considerably (p <0.0001 and p <0.01) as compared with the standard treatment. CONCLUSION: Our results indicate the importance of the time interval between the daily fractions in hyperfractionated and accelerated radiotherapy.
M3 - SCORING: Zeitschriftenaufsatz
VL - 170
SP - 232
EP - 234
JO - STRAHLENTHER ONKOL
JF - STRAHLENTHER ONKOL
SN - 0179-7158
IS - 4
M1 - 4
ER -