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The effect of opioid receptor blockade on the neural processing of thermal stimuli.

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The effect of opioid receptor blockade on the neural processing of thermal stimuli. / Schoell, Eszter D; Bingel, Ulrike; Eippert, Falk; Yacubian, Juliana; Christiansen, Kerrin; Andresen, Hilke; May, Arne; Buechel, Christian.

in: PLOS ONE, Jahrgang 5, Nr. 8, 8, 2010, S. 12344.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schoell, ED, Bingel, U, Eippert, F, Yacubian, J, Christiansen, K, Andresen, H, May, A & Buechel, C 2010, 'The effect of opioid receptor blockade on the neural processing of thermal stimuli.', PLOS ONE, Jg. 5, Nr. 8, 8, S. 12344.

APA

Schoell, E. D., Bingel, U., Eippert, F., Yacubian, J., Christiansen, K., Andresen, H., May, A., & Buechel, C. (2010). The effect of opioid receptor blockade on the neural processing of thermal stimuli. PLOS ONE, 5(8), 12344. [8].

Vancouver

Schoell ED, Bingel U, Eippert F, Yacubian J, Christiansen K, Andresen H et al. The effect of opioid receptor blockade on the neural processing of thermal stimuli. PLOS ONE. 2010;5(8):12344. 8.

Bibtex

@article{7ea6bbfe8f3d463295b0f3e5a95808b2,
title = "The effect of opioid receptor blockade on the neural processing of thermal stimuli.",
abstract = "The endogenous opioid system represents one of the principal systems in the modulation of pain. This has been demonstrated in studies of placebo analgesia and stress-induced analgesia, where anti-nociceptive activity triggered by pain itself or by cognitive states is blocked by opioid antagonists. The aim of this study was to characterize the effect of opioid receptor blockade on the physiological processing of painful thermal stimulation in the absence of cognitive manipulation. We therefore measured BOLD (blood oxygen level dependent) signal responses and intensity ratings to non-painful and painful thermal stimuli in a double-blind, cross-over design using the opioid receptor antagonist naloxone. On the behavioral level, we observed an increase in intensity ratings under naloxone due mainly to a difference in the non-painful stimuli. On the neural level, painful thermal stimulation was associated with a negative BOLD signal within the pregenual anterior cingulate cortex, and this deactivation was abolished by naloxone.",
author = "Schoell, {Eszter D} and Ulrike Bingel and Falk Eippert and Juliana Yacubian and Kerrin Christiansen and Hilke Andresen and Arne May and Christian Buechel",
year = "2010",
language = "Deutsch",
volume = "5",
pages = "12344",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

RIS

TY - JOUR

T1 - The effect of opioid receptor blockade on the neural processing of thermal stimuli.

AU - Schoell, Eszter D

AU - Bingel, Ulrike

AU - Eippert, Falk

AU - Yacubian, Juliana

AU - Christiansen, Kerrin

AU - Andresen, Hilke

AU - May, Arne

AU - Buechel, Christian

PY - 2010

Y1 - 2010

N2 - The endogenous opioid system represents one of the principal systems in the modulation of pain. This has been demonstrated in studies of placebo analgesia and stress-induced analgesia, where anti-nociceptive activity triggered by pain itself or by cognitive states is blocked by opioid antagonists. The aim of this study was to characterize the effect of opioid receptor blockade on the physiological processing of painful thermal stimulation in the absence of cognitive manipulation. We therefore measured BOLD (blood oxygen level dependent) signal responses and intensity ratings to non-painful and painful thermal stimuli in a double-blind, cross-over design using the opioid receptor antagonist naloxone. On the behavioral level, we observed an increase in intensity ratings under naloxone due mainly to a difference in the non-painful stimuli. On the neural level, painful thermal stimulation was associated with a negative BOLD signal within the pregenual anterior cingulate cortex, and this deactivation was abolished by naloxone.

AB - The endogenous opioid system represents one of the principal systems in the modulation of pain. This has been demonstrated in studies of placebo analgesia and stress-induced analgesia, where anti-nociceptive activity triggered by pain itself or by cognitive states is blocked by opioid antagonists. The aim of this study was to characterize the effect of opioid receptor blockade on the physiological processing of painful thermal stimulation in the absence of cognitive manipulation. We therefore measured BOLD (blood oxygen level dependent) signal responses and intensity ratings to non-painful and painful thermal stimuli in a double-blind, cross-over design using the opioid receptor antagonist naloxone. On the behavioral level, we observed an increase in intensity ratings under naloxone due mainly to a difference in the non-painful stimuli. On the neural level, painful thermal stimulation was associated with a negative BOLD signal within the pregenual anterior cingulate cortex, and this deactivation was abolished by naloxone.

M3 - SCORING: Zeitschriftenaufsatz

VL - 5

SP - 12344

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 8

M1 - 8

ER -