The effect of dexamethasone dosage upon plasma cortisol and dexamethasone during the DST.
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The effect of dexamethasone dosage upon plasma cortisol and dexamethasone during the DST. / Wiedemann, Klaus; Holsboer, F.
in: J AFFECT DISORDERS, Jahrgang 19, Nr. 2, 2, 1990, S. 133-137.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The effect of dexamethasone dosage upon plasma cortisol and dexamethasone during the DST.
AU - Wiedemann, Klaus
AU - Holsboer, F
PY - 1990
Y1 - 1990
N2 - To investigate the effect of dexamethasone dosage upon the outcome of the dexamethasone suppression test (DST) and the role of concurrent plasma dexamethasone concentrations, four different dexamethasone dosages were administered to 119 hospitalized depressed patients (0.5 mg: n = 12; 1.0 mg: n = 30; 1.5 mg: n = 42; 2.0 mg: n = 35). Independent of the dosage, dexamethasone plasma concentrations at 4.00 p.m. were lower in DST non-suppressors than in suppressors, although differences were statistically significant only for the 1.5-mg and 2.0-mg dosages. Our findings confirm recent reports that the actual plasma concentration of dexamethasone at 4.00 p.m. does not determine DST outcome.
AB - To investigate the effect of dexamethasone dosage upon the outcome of the dexamethasone suppression test (DST) and the role of concurrent plasma dexamethasone concentrations, four different dexamethasone dosages were administered to 119 hospitalized depressed patients (0.5 mg: n = 12; 1.0 mg: n = 30; 1.5 mg: n = 42; 2.0 mg: n = 35). Independent of the dosage, dexamethasone plasma concentrations at 4.00 p.m. were lower in DST non-suppressors than in suppressors, although differences were statistically significant only for the 1.5-mg and 2.0-mg dosages. Our findings confirm recent reports that the actual plasma concentration of dexamethasone at 4.00 p.m. does not determine DST outcome.
M3 - SCORING: Zeitschriftenaufsatz
VL - 19
SP - 133
EP - 137
JO - J AFFECT DISORDERS
JF - J AFFECT DISORDERS
SN - 0165-0327
IS - 2
M1 - 2
ER -
