PortalPublikationenThe dual orexin receptor antagonist almorexant induces sleep...

The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.

Standard

The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors. / Mang, Géraldine M; Dürst, Thomas; Bürki, Hugo; Imobersteg, Stefan; Abramowski, Dorothee; Schuepbach, Edi; Hoyer, Daniel; Fendt, Markus; Gee, Christine E.

in: SLEEP, Jahrgang 35, Nr. 12, 12, 2012, S. 1625-1635.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mang, GM, Dürst, T, Bürki, H, Imobersteg, S, Abramowski, D, Schuepbach, E, Hoyer, D, Fendt, M & Gee, CE 2012, 'The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.', SLEEP, Jg. 35, Nr. 12, 12, S. 1625-1635. <http://www.ncbi.nlm.nih.gov/pubmed/23204605?dopt=Citation>

APA

Mang, G. M., Dürst, T., Bürki, H., Imobersteg, S., Abramowski, D., Schuepbach, E., Hoyer, D., Fendt, M., & Gee, C. E. (2012). The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors. SLEEP, 35(12), 1625-1635. [12]. http://www.ncbi.nlm.nih.gov/pubmed/23204605?dopt=Citation

Vancouver

Mang GM, Dürst T, Bürki H, Imobersteg S, Abramowski D, Schuepbach E et al. The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors. SLEEP. 2012;35(12):1625-1635. 12.

Bibtex

@article{02a2f597f9164aefaa67e57c0cdc568f,
title = "The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.",
abstract = "Orexin peptides activate orexin 1 and orexin 2 receptors (OX(1)R and OX(2)R), regulate locomotion and sleep-wake. The dual OX(1)R/OX(2)R antagonist almorexant reduces activity and promotes sleep in multiple species, including man. The relative contributions of the two receptors in locomotion and sleep/wake regulation were investigated in mice.",
keywords = "Animals, Male, Mice, Mice, Inbred C57BL, Acetamides/*pharmacology, Intracellular Signaling Peptides and Proteins/*pharmacology, Isoquinolines/*pharmacology, Locomotion/*drug effects/physiology, Neuropeptides/*pharmacology, Receptors, G-Protein-Coupled/*antagonists & inhibitors/physiology, Receptors, Neuropeptide/*antagonists & inhibitors/physiology, Sleep/*drug effects/physiology, Sympathomimetics/*pharmacology, Wakefulness/drug effects/physiology, Animals, Male, Mice, Mice, Inbred C57BL, Acetamides/*pharmacology, Intracellular Signaling Peptides and Proteins/*pharmacology, Isoquinolines/*pharmacology, Locomotion/*drug effects/physiology, Neuropeptides/*pharmacology, Receptors, G-Protein-Coupled/*antagonists & inhibitors/physiology, Receptors, Neuropeptide/*antagonists & inhibitors/physiology, Sleep/*drug effects/physiology, Sympathomimetics/*pharmacology, Wakefulness/drug effects/physiology",
author = "Mang, {G{\'e}raldine M} and Thomas D{\"u}rst and Hugo B{\"u}rki and Stefan Imobersteg and Dorothee Abramowski and Edi Schuepbach and Daniel Hoyer and Markus Fendt and Gee, {Christine E.}",
year = "2012",
language = "English",
volume = "35",
pages = "1625--1635",
journal = "SLEEP",
issn = "0161-8105",
publisher = "American Academy of Sleep Medicine",
number = "12",

}

RIS

TY - JOUR

T1 - The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.

AU - Mang, Géraldine M

AU - Dürst, Thomas

AU - Bürki, Hugo

AU - Imobersteg, Stefan

AU - Abramowski, Dorothee

AU - Schuepbach, Edi

AU - Hoyer, Daniel

AU - Fendt, Markus

AU - Gee, Christine E.

PY - 2012

Y1 - 2012

N2 - Orexin peptides activate orexin 1 and orexin 2 receptors (OX(1)R and OX(2)R), regulate locomotion and sleep-wake. The dual OX(1)R/OX(2)R antagonist almorexant reduces activity and promotes sleep in multiple species, including man. The relative contributions of the two receptors in locomotion and sleep/wake regulation were investigated in mice.

AB - Orexin peptides activate orexin 1 and orexin 2 receptors (OX(1)R and OX(2)R), regulate locomotion and sleep-wake. The dual OX(1)R/OX(2)R antagonist almorexant reduces activity and promotes sleep in multiple species, including man. The relative contributions of the two receptors in locomotion and sleep/wake regulation were investigated in mice.

KW - Animals

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Acetamides/pharmacology

KW - Intracellular Signaling Peptides and Proteins/pharmacology

KW - Isoquinolines/pharmacology

KW - Locomotion/drug effects/physiology

KW - Neuropeptides/pharmacology

KW - Receptors, G-Protein-Coupled/antagonists & inhibitors/physiology

KW - Receptors, Neuropeptide/antagonists & inhibitors/physiology

KW - Sleep/drug effects/physiology

KW - Sympathomimetics/pharmacology

KW - Wakefulness/drug effects/physiology

KW - Animals

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Acetamides/pharmacology

KW - Intracellular Signaling Peptides and Proteins/pharmacology

KW - Isoquinolines/pharmacology

KW - Locomotion/drug effects/physiology

KW - Neuropeptides/pharmacology

KW - Receptors, G-Protein-Coupled/antagonists & inhibitors/physiology

KW - Receptors, Neuropeptide/antagonists & inhibitors/physiology

KW - Sleep/drug effects/physiology

KW - Sympathomimetics/pharmacology

KW - Wakefulness/drug effects/physiology

M3 - SCORING: Journal article

VL - 35

SP - 1625

EP - 1635

JO - SLEEP

JF - SLEEP

SN - 0161-8105

IS - 12

M1 - 12

ER -