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The distribution of whole blood viscosity, its determinants and relationship with arterial blood pressure in the community: cross-sectional analysis from the Gutenberg Health Study

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The distribution of whole blood viscosity, its determinants and relationship with arterial blood pressure in the community: cross-sectional analysis from the Gutenberg Health Study. / Gori, Tommaso; Wild, Philipp S; Schnabel, Renate; Schulz, Andreas; Pfeiffer, Norbert; Blettner, Maria; Beutel, Manfred E; Forconi, Sandro; Jung, Friedrich; Lackner, Karl J; Blankenberg, Stefan; Münzel, Thomas.

in: THER ADV CARDIO DIS, Jahrgang 9, Nr. 6, 12.2015, S. 354-365.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gori, T, Wild, PS, Schnabel, R, Schulz, A, Pfeiffer, N, Blettner, M, Beutel, ME, Forconi, S, Jung, F, Lackner, KJ, Blankenberg, S & Münzel, T 2015, 'The distribution of whole blood viscosity, its determinants and relationship with arterial blood pressure in the community: cross-sectional analysis from the Gutenberg Health Study', THER ADV CARDIO DIS, Jg. 9, Nr. 6, S. 354-365. https://doi.org/10.1177/1753944715589887

APA

Gori, T., Wild, P. S., Schnabel, R., Schulz, A., Pfeiffer, N., Blettner, M., Beutel, M. E., Forconi, S., Jung, F., Lackner, K. J., Blankenberg, S., & Münzel, T. (2015). The distribution of whole blood viscosity, its determinants and relationship with arterial blood pressure in the community: cross-sectional analysis from the Gutenberg Health Study. THER ADV CARDIO DIS, 9(6), 354-365. https://doi.org/10.1177/1753944715589887

Vancouver

Gori T, Wild PS, Schnabel R, Schulz A, Pfeiffer N, Blettner M et al. The distribution of whole blood viscosity, its determinants and relationship with arterial blood pressure in the community: cross-sectional analysis from the Gutenberg Health Study. THER ADV CARDIO DIS. 2015 Dez;9(6):354-365. https://doi.org/10.1177/1753944715589887

Bibtex

@article{d8de2b2b9c784d31907027d197a3016e,
title = "The distribution of whole blood viscosity, its determinants and relationship with arterial blood pressure in the community: cross-sectional analysis from the Gutenberg Health Study",
abstract = "BACKGROUND: Blood viscosity has a role in modulating cardiovascular homeostasis; changes in this parameter have been associated with cardiovascular mortality and morbidity. However, it remains unclear whether these changes are (1) involved in the pathophysiology of disease, (2) an epiphenomenon, or (3) the expression of counterregulatory mechanisms. We report data on the normal values of blood viscosity and its association with cardiovascular risk factors, prevalent cardiovascular disease, and blood pressure in a large population-based cohort study.METHODS AND RESULTS: Viscosity was calculated using validated formulae and its associations were explored in 15,010 participants (mean 55.0, min-max: 35-74 years old; 49.5% women) from the Gutenberg Health Study as well as in a subgroup of 3223 subjects (61.1% women, mean age 49.2, min-max 35-74 years old) without risk factors or self-reported cardiovascular disease. Age- and gender-adjusted mean values for viscosity were defined. Regression models showed a relationship between classical risk factors and blood viscosity measures; the overall R(2) of the multiple linear regression model was however as low as 0.067 and 0.049 for high and low shear stress viscosity, respectively. After correction for cardiovascular risk factors, there was a very mild association between viscosity and prevalent coronary artery disease and heart failure. Systolic, mean and diastolic blood pressure increased with increasing blood viscosity after correction for age and gender.CONCLUSIONS: We provide reference values for viscosity in a population-based cohort. Blood viscosity decreases in older subjects and shows a very mild association with cardiovascular risk factors and prevalent disease in our cohort. There is a linear positive association between viscosity and blood pressure.",
keywords = "Adult, Aged, Arterial Pressure, Blood Viscosity, Cardiovascular Diseases/blood, Coronary Artery Disease/blood, Cross-Sectional Studies, Female, Germany/epidemiology, Health Surveys, Heart Failure/blood, Humans, Linear Models, Logistic Models, Male, Middle Aged, Prevalence, Reference Values, Risk Assessment, Risk Factors",
author = "Tommaso Gori and Wild, {Philipp S} and Renate Schnabel and Andreas Schulz and Norbert Pfeiffer and Maria Blettner and Beutel, {Manfred E} and Sandro Forconi and Friedrich Jung and Lackner, {Karl J} and Stefan Blankenberg and Thomas M{\"u}nzel",
note = "{\textcopyright} The Author(s), 2015.",
year = "2015",
month = dec,
doi = "10.1177/1753944715589887",
language = "English",
volume = "9",
pages = "354--365",
journal = "THER ADV CARDIO DIS",
issn = "1753-9447",
publisher = "SAGE Publications",
number = "6",

}

RIS

TY - JOUR

T1 - The distribution of whole blood viscosity, its determinants and relationship with arterial blood pressure in the community: cross-sectional analysis from the Gutenberg Health Study

AU - Gori, Tommaso

AU - Wild, Philipp S

AU - Schnabel, Renate

AU - Schulz, Andreas

AU - Pfeiffer, Norbert

AU - Blettner, Maria

AU - Beutel, Manfred E

AU - Forconi, Sandro

AU - Jung, Friedrich

AU - Lackner, Karl J

AU - Blankenberg, Stefan

AU - Münzel, Thomas

N1 - © The Author(s), 2015.

PY - 2015/12

Y1 - 2015/12

N2 - BACKGROUND: Blood viscosity has a role in modulating cardiovascular homeostasis; changes in this parameter have been associated with cardiovascular mortality and morbidity. However, it remains unclear whether these changes are (1) involved in the pathophysiology of disease, (2) an epiphenomenon, or (3) the expression of counterregulatory mechanisms. We report data on the normal values of blood viscosity and its association with cardiovascular risk factors, prevalent cardiovascular disease, and blood pressure in a large population-based cohort study.METHODS AND RESULTS: Viscosity was calculated using validated formulae and its associations were explored in 15,010 participants (mean 55.0, min-max: 35-74 years old; 49.5% women) from the Gutenberg Health Study as well as in a subgroup of 3223 subjects (61.1% women, mean age 49.2, min-max 35-74 years old) without risk factors or self-reported cardiovascular disease. Age- and gender-adjusted mean values for viscosity were defined. Regression models showed a relationship between classical risk factors and blood viscosity measures; the overall R(2) of the multiple linear regression model was however as low as 0.067 and 0.049 for high and low shear stress viscosity, respectively. After correction for cardiovascular risk factors, there was a very mild association between viscosity and prevalent coronary artery disease and heart failure. Systolic, mean and diastolic blood pressure increased with increasing blood viscosity after correction for age and gender.CONCLUSIONS: We provide reference values for viscosity in a population-based cohort. Blood viscosity decreases in older subjects and shows a very mild association with cardiovascular risk factors and prevalent disease in our cohort. There is a linear positive association between viscosity and blood pressure.

AB - BACKGROUND: Blood viscosity has a role in modulating cardiovascular homeostasis; changes in this parameter have been associated with cardiovascular mortality and morbidity. However, it remains unclear whether these changes are (1) involved in the pathophysiology of disease, (2) an epiphenomenon, or (3) the expression of counterregulatory mechanisms. We report data on the normal values of blood viscosity and its association with cardiovascular risk factors, prevalent cardiovascular disease, and blood pressure in a large population-based cohort study.METHODS AND RESULTS: Viscosity was calculated using validated formulae and its associations were explored in 15,010 participants (mean 55.0, min-max: 35-74 years old; 49.5% women) from the Gutenberg Health Study as well as in a subgroup of 3223 subjects (61.1% women, mean age 49.2, min-max 35-74 years old) without risk factors or self-reported cardiovascular disease. Age- and gender-adjusted mean values for viscosity were defined. Regression models showed a relationship between classical risk factors and blood viscosity measures; the overall R(2) of the multiple linear regression model was however as low as 0.067 and 0.049 for high and low shear stress viscosity, respectively. After correction for cardiovascular risk factors, there was a very mild association between viscosity and prevalent coronary artery disease and heart failure. Systolic, mean and diastolic blood pressure increased with increasing blood viscosity after correction for age and gender.CONCLUSIONS: We provide reference values for viscosity in a population-based cohort. Blood viscosity decreases in older subjects and shows a very mild association with cardiovascular risk factors and prevalent disease in our cohort. There is a linear positive association between viscosity and blood pressure.

KW - Adult

KW - Aged

KW - Arterial Pressure

KW - Blood Viscosity

KW - Cardiovascular Diseases/blood

KW - Coronary Artery Disease/blood

KW - Cross-Sectional Studies

KW - Female

KW - Germany/epidemiology

KW - Health Surveys

KW - Heart Failure/blood

KW - Humans

KW - Linear Models

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Reference Values

KW - Risk Assessment

KW - Risk Factors

U2 - 10.1177/1753944715589887

DO - 10.1177/1753944715589887

M3 - SCORING: Journal article

C2 - 26082340

VL - 9

SP - 354

EP - 365

JO - THER ADV CARDIO DIS

JF - THER ADV CARDIO DIS

SN - 1753-9447

IS - 6

ER -