The diagnostic accuracy of 332 incisional biopsies in patients with malignant tumors in the musculoskeletal system

TY - JOUR

T1 - The diagnostic accuracy of 332 incisional biopsies in patients with malignant tumors in the musculoskeletal system

AU - Dirks, Michael

AU - Ewerbeck, Nicolas Konstantin

AU - Ballhause, Tobias Malte

AU - Weiß, Sebastian

AU - Luebke, Andreas M.

AU - Schlickewei, Carsten

AU - Frosch, Karl-Heinz

AU - Priemel, Matthias

PY - 2023/1/9

Y1 - 2023/1/9

N2 - BACKGROUND: It is known that specimen collection followed by histopathological workup is the core of evidence-based medical therapy of musculoskeletal tumors. There exist many controversies about how a biopsy should be performed. While some centers recommend minimal invasive biopsy procedures, mostly the core needle biopsy (CNB), others prefer the incisional biopsy.PURPOSE OF THE STUDY: This study aimed to determine the accuracy of incisional biopsy for malignant tumors in the musculoskeletal system. Moreover, advantages and disadvantages to other biopsy methods are discussed.METHODS: This retrospective, single-center study about 844 incisional biopsies (benign and malignant) analysis the diagnostic accuracy of 332 malignant tumors, concerning the final histopathological result. In addition, surgical complications are analyzed to find the best way to plan and treat patients timely and correct. Secondary endpoints are the patients age, the pure operation time, as well as the type of tumor, and the subsequent therapy.RESULTS: In summary, incisional biopsy corresponded a sensitivity of 100% for malignancy in 844 incisional biopsies and a specificity of 97.6% in 332 malignant tumors, but it features greater operative expense (incision/suture 23.5 min) and the risk of general anesthesia.CONCLUSION: The method of biopsy should be tailored to the individual patient and the experience of the center performing the procedure.

AB - BACKGROUND: It is known that specimen collection followed by histopathological workup is the core of evidence-based medical therapy of musculoskeletal tumors. There exist many controversies about how a biopsy should be performed. While some centers recommend minimal invasive biopsy procedures, mostly the core needle biopsy (CNB), others prefer the incisional biopsy.PURPOSE OF THE STUDY: This study aimed to determine the accuracy of incisional biopsy for malignant tumors in the musculoskeletal system. Moreover, advantages and disadvantages to other biopsy methods are discussed.METHODS: This retrospective, single-center study about 844 incisional biopsies (benign and malignant) analysis the diagnostic accuracy of 332 malignant tumors, concerning the final histopathological result. In addition, surgical complications are analyzed to find the best way to plan and treat patients timely and correct. Secondary endpoints are the patients age, the pure operation time, as well as the type of tumor, and the subsequent therapy.RESULTS: In summary, incisional biopsy corresponded a sensitivity of 100% for malignancy in 844 incisional biopsies and a specificity of 97.6% in 332 malignant tumors, but it features greater operative expense (incision/suture 23.5 min) and the risk of general anesthesia.CONCLUSION: The method of biopsy should be tailored to the individual patient and the experience of the center performing the procedure.

U2 - 10.1186/s12957-022-02883-w

DO - 10.1186/s12957-022-02883-w

M3 - SCORING: Journal article

C2 - 36624456

VL - 21

SP - 4

JO - WORLD J SURG ONCOL

JF - WORLD J SURG ONCOL

SN - 1477-7819

IS - 1

M1 - 4

ER -