The diagnosis of benign prostatic obstruction: Development of a clinical nomogram
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The diagnosis of benign prostatic obstruction: Development of a clinical nomogram. / De Nunzio, Cosimo; Autorino, Riccardo; Bachmann, Alexander; Briganti, Alberto; Carter, Simon; Chun, Felix; Novara, Giacomo; Sosnowski, Roman; Thiruchelvam, Nickesh; Tubaro, Andrea; Ahyai, Sascha; EAU Young Academic Urologists BPH Group Arnhem, The Netherlands.
in: NEUROUROL URODYNAM, Jahrgang 35, Nr. 2, 02.2016, S. 235-40.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The diagnosis of benign prostatic obstruction: Development of a clinical nomogram
AU - De Nunzio, Cosimo
AU - Autorino, Riccardo
AU - Bachmann, Alexander
AU - Briganti, Alberto
AU - Carter, Simon
AU - Chun, Felix
AU - Novara, Giacomo
AU - Sosnowski, Roman
AU - Thiruchelvam, Nickesh
AU - Tubaro, Andrea
AU - Ahyai, Sascha
AU - EAU Young Academic Urologists BPH Group Arnhem, The Netherlands
N1 - © 2014 Wiley Periodicals, Inc.
PY - 2016/2
Y1 - 2016/2
N2 - AIMS: To develop a nomogram predicting benign prostatic obstruction (BPO).METHODS: We included in this study 600 men with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE) who underwent standardized pressure flow studies (PFS) between 1996 and 2000. Complete clinical and urodynamic data were available for all patients. Variables assessed in univariate and multivariate logistic regression models consisted of IPSS, PSA, prostate size, maximal urinary flow rate (Qmax) at free flow, residual urine (RU), and bladder wall thickness (BWT). These were used to predict significant BPO (defined as a Schäfer grade ≥ 3 in PFS).RESULTS: A preliminary multivariate model, including IPSS, Qmax at free flow and RU, suggested that only Qmax at free flow was a statistically significant predictor of BPO (P = 0.00) with a predictive accuracy (PA) of 82%. Further development of the multivariate model showed how the inclusion of BWT did not increase PA. Only transitional zone volume (TZV) proved to be an additional statistically significant predictor for BPO (P = 0.00). The combination of Qmax at free flow and TZV demonstrated a PA of 83.2% and were included in the final nomogram format.CONCLUSIONS: We developed a clinical nomogram, which is both accurate and well calibrated, which can be helpful in the management of patients with LUTS and BPE. External validation is warranted to confirm our findings. Neurourol. Urodynam. 35:235-240, 2016. © 2014 Wiley Periodicals, Inc.
AB - AIMS: To develop a nomogram predicting benign prostatic obstruction (BPO).METHODS: We included in this study 600 men with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE) who underwent standardized pressure flow studies (PFS) between 1996 and 2000. Complete clinical and urodynamic data were available for all patients. Variables assessed in univariate and multivariate logistic regression models consisted of IPSS, PSA, prostate size, maximal urinary flow rate (Qmax) at free flow, residual urine (RU), and bladder wall thickness (BWT). These were used to predict significant BPO (defined as a Schäfer grade ≥ 3 in PFS).RESULTS: A preliminary multivariate model, including IPSS, Qmax at free flow and RU, suggested that only Qmax at free flow was a statistically significant predictor of BPO (P = 0.00) with a predictive accuracy (PA) of 82%. Further development of the multivariate model showed how the inclusion of BWT did not increase PA. Only transitional zone volume (TZV) proved to be an additional statistically significant predictor for BPO (P = 0.00). The combination of Qmax at free flow and TZV demonstrated a PA of 83.2% and were included in the final nomogram format.CONCLUSIONS: We developed a clinical nomogram, which is both accurate and well calibrated, which can be helpful in the management of patients with LUTS and BPE. External validation is warranted to confirm our findings. Neurourol. Urodynam. 35:235-240, 2016. © 2014 Wiley Periodicals, Inc.
U2 - 10.1002/nau.22705
DO - 10.1002/nau.22705
M3 - SCORING: Journal article
C2 - 25524269
VL - 35
SP - 235
EP - 240
JO - NEUROUROL URODYNAM
JF - NEUROUROL URODYNAM
SN - 0733-2467
IS - 2
ER -