The determination of GGT is the most reliable predictor of nonresponsiveness to interferon-alpha based therapy in HCV type-1 infection.
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The determination of GGT is the most reliable predictor of nonresponsiveness to interferon-alpha based therapy in HCV type-1 infection. / Weich, Viola; Herrmann, Eva; Chung, Tje Lin; Sarrazin, Christoph; Hinrichsen, Holger; Buggisch, Peter; Gerlach, Tilman; Klinker, Hartwig; Spengler, Ulrich; Bergk, Alexandra; Zeuzem, Stefan; Berg, Thomas.
in: J GASTROENTEROL, Jahrgang 46, Nr. 12, 12, 2011, S. 1427-1436.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The determination of GGT is the most reliable predictor of nonresponsiveness to interferon-alpha based therapy in HCV type-1 infection.
AU - Weich, Viola
AU - Herrmann, Eva
AU - Chung, Tje Lin
AU - Sarrazin, Christoph
AU - Hinrichsen, Holger
AU - Buggisch, Peter
AU - Gerlach, Tilman
AU - Klinker, Hartwig
AU - Spengler, Ulrich
AU - Bergk, Alexandra
AU - Zeuzem, Stefan
AU - Berg, Thomas
PY - 2011
Y1 - 2011
N2 - The critical analysis of baseline factors has been found to be useful to predict virologic nonresponse (NR), relapse, or sustained virologic response (SVR) in patients infected with hepatitis C virus (HCV) who receive antiviral therapy. In the present retrospective study we tried to find out whether gamma-glutamyltranspeptidase (GGT) may be one of the baseline factors which are of special predictive power. We analyzed, in patients with different treatment outcomes, the predictive power of established baseline factors either in combination with GGT or by evaluating the predictive value of GGT independently.
AB - The critical analysis of baseline factors has been found to be useful to predict virologic nonresponse (NR), relapse, or sustained virologic response (SVR) in patients infected with hepatitis C virus (HCV) who receive antiviral therapy. In the present retrospective study we tried to find out whether gamma-glutamyltranspeptidase (GGT) may be one of the baseline factors which are of special predictive power. We analyzed, in patients with different treatment outcomes, the predictive power of established baseline factors either in combination with GGT or by evaluating the predictive value of GGT independently.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Multivariate Analysis
KW - Treatment Outcome
KW - Reproducibility of Results
KW - Predictive Value of Tests
KW - Logistic Models
KW - Retrospective Studies
KW - Drug Therapy, Combination
KW - Hepatitis C, Chronic/drug therapy/virology
KW - Antiviral Agents/administration & dosage/therapeutic use
KW - Interferon-alpha/administration & dosage/therapeutic use
KW - Polyethylene Glycols/administration & dosage/therapeutic use
KW - Recombinant Proteins/administration & dosage/therapeutic use
KW - Ribavirin/administration & dosage/therapeutic use
KW - gamma-Glutamyltransferase/blood
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Multivariate Analysis
KW - Treatment Outcome
KW - Reproducibility of Results
KW - Predictive Value of Tests
KW - Logistic Models
KW - Retrospective Studies
KW - Drug Therapy, Combination
KW - Hepatitis C, Chronic/drug therapy/virology
KW - Antiviral Agents/administration & dosage/therapeutic use
KW - Interferon-alpha/administration & dosage/therapeutic use
KW - Polyethylene Glycols/administration & dosage/therapeutic use
KW - Recombinant Proteins/administration & dosage/therapeutic use
KW - Ribavirin/administration & dosage/therapeutic use
KW - gamma-Glutamyltransferase/blood
M3 - SCORING: Journal article
VL - 46
SP - 1427
EP - 1436
JO - J GASTROENTEROL
JF - J GASTROENTEROL
SN - 0944-1174
IS - 12
M1 - 12
ER -
