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The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis

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The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis. / Langhein, Mina; Lyall, Amanda E; Steinmann, Saskia; Seitz-Holland, Johanna; Nägele, Felix L; Cetin-Karayumak, Suheyla; Zhang, Fan; Rauh, Jonas; Mußmann, Marius; Billah, Tashrif; Makris, Nikos; Pasternak, Ofer; O'Donnell, Lauren J; Rathi, Yogesh; Leicht, Gregor; Kubicki, Marek; Shenton, Martha E; Mulert, Christoph.

in: WORLD J BIOL PSYCHIA, Jahrgang 24, Nr. 5, 06.2023, S. 387-399.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Langhein, M, Lyall, AE, Steinmann, S, Seitz-Holland, J, Nägele, FL, Cetin-Karayumak, S, Zhang, F, Rauh, J, Mußmann, M, Billah, T, Makris, N, Pasternak, O, O'Donnell, LJ, Rathi, Y, Leicht, G, Kubicki, M, Shenton, ME & Mulert, C 2023, 'The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis', WORLD J BIOL PSYCHIA, Jg. 24, Nr. 5, S. 387-399. https://doi.org/10.1080/15622975.2022.2112974

APA

Langhein, M., Lyall, A. E., Steinmann, S., Seitz-Holland, J., Nägele, F. L., Cetin-Karayumak, S., Zhang, F., Rauh, J., Mußmann, M., Billah, T., Makris, N., Pasternak, O., O'Donnell, L. J., Rathi, Y., Leicht, G., Kubicki, M., Shenton, M. E., & Mulert, C. (2023). The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis. WORLD J BIOL PSYCHIA, 24(5), 387-399. https://doi.org/10.1080/15622975.2022.2112974

Vancouver

Langhein M, Lyall AE, Steinmann S, Seitz-Holland J, Nägele FL, Cetin-Karayumak S et al. The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis. WORLD J BIOL PSYCHIA. 2023 Jun;24(5):387-399. https://doi.org/10.1080/15622975.2022.2112974

Bibtex

@article{3b592638684e44a5b1fe2f8043d9ad1e,
title = "The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis",
abstract = "OBJECTIVES: Disrupted auditory networks play an important role in the pathophysiology of psychosis, with abnormalities already observed in individuals at clinical high-risk for psychosis (CHR). Here, we examine structural and functional connectivity of an auditory network in CHR utilising state-of-the-art electroencephalography and diffusion imaging techniques.METHODS: Twenty-six CHR subjects and 13 healthy controls (HC) underwent diffusion MRI and electroencephalography while performing an auditory task. We investigated structural connectivity, measured as fractional anisotropy in the Arcuate Fasciculus (AF), Cingulum Bundle, and Superior Longitudinal Fasciculus-II. Gamma-band lagged-phase synchronisation, a functional connectivity measure, was calculated between cortical regions connected by these tracts.RESULTS: CHR subjects showed significantly higher structural connectivity in the right AF than HC (p < .001). Although non-significant, functional connectivity between cortical areas connected by the AF was lower in CHR than HC (p = .078). Structural and functional connectivity were correlated in HC (p = .056) but not in CHR (p = .29).CONCLUSIONS: We observe significant differences in structural connectivity of the AF, without a concomitant significant change in functional connectivity in CHR subjects. This may suggest that the CHR state is characterised by a decoupling of structural and functional connectivity, possibly due to abnormal white matter maturation.",
author = "Mina Langhein and Lyall, {Amanda E} and Saskia Steinmann and Johanna Seitz-Holland and N{\"a}gele, {Felix L} and Suheyla Cetin-Karayumak and Fan Zhang and Jonas Rauh and Marius Mu{\ss}mann and Tashrif Billah and Nikos Makris and Ofer Pasternak and O'Donnell, {Lauren J} and Yogesh Rathi and Gregor Leicht and Marek Kubicki and Shenton, {Martha E} and Christoph Mulert",
year = "2023",
month = jun,
doi = "10.1080/15622975.2022.2112974",
language = "English",
volume = "24",
pages = "387--399",
journal = "WORLD J BIOL PSYCHIA",
issn = "1562-2975",
publisher = "informa healthcare",
number = "5",

}

RIS

TY - JOUR

T1 - The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis

AU - Langhein, Mina

AU - Lyall, Amanda E

AU - Steinmann, Saskia

AU - Seitz-Holland, Johanna

AU - Nägele, Felix L

AU - Cetin-Karayumak, Suheyla

AU - Zhang, Fan

AU - Rauh, Jonas

AU - Mußmann, Marius

AU - Billah, Tashrif

AU - Makris, Nikos

AU - Pasternak, Ofer

AU - O'Donnell, Lauren J

AU - Rathi, Yogesh

AU - Leicht, Gregor

AU - Kubicki, Marek

AU - Shenton, Martha E

AU - Mulert, Christoph

PY - 2023/6

Y1 - 2023/6

N2 - OBJECTIVES: Disrupted auditory networks play an important role in the pathophysiology of psychosis, with abnormalities already observed in individuals at clinical high-risk for psychosis (CHR). Here, we examine structural and functional connectivity of an auditory network in CHR utilising state-of-the-art electroencephalography and diffusion imaging techniques.METHODS: Twenty-six CHR subjects and 13 healthy controls (HC) underwent diffusion MRI and electroencephalography while performing an auditory task. We investigated structural connectivity, measured as fractional anisotropy in the Arcuate Fasciculus (AF), Cingulum Bundle, and Superior Longitudinal Fasciculus-II. Gamma-band lagged-phase synchronisation, a functional connectivity measure, was calculated between cortical regions connected by these tracts.RESULTS: CHR subjects showed significantly higher structural connectivity in the right AF than HC (p < .001). Although non-significant, functional connectivity between cortical areas connected by the AF was lower in CHR than HC (p = .078). Structural and functional connectivity were correlated in HC (p = .056) but not in CHR (p = .29).CONCLUSIONS: We observe significant differences in structural connectivity of the AF, without a concomitant significant change in functional connectivity in CHR subjects. This may suggest that the CHR state is characterised by a decoupling of structural and functional connectivity, possibly due to abnormal white matter maturation.

AB - OBJECTIVES: Disrupted auditory networks play an important role in the pathophysiology of psychosis, with abnormalities already observed in individuals at clinical high-risk for psychosis (CHR). Here, we examine structural and functional connectivity of an auditory network in CHR utilising state-of-the-art electroencephalography and diffusion imaging techniques.METHODS: Twenty-six CHR subjects and 13 healthy controls (HC) underwent diffusion MRI and electroencephalography while performing an auditory task. We investigated structural connectivity, measured as fractional anisotropy in the Arcuate Fasciculus (AF), Cingulum Bundle, and Superior Longitudinal Fasciculus-II. Gamma-band lagged-phase synchronisation, a functional connectivity measure, was calculated between cortical regions connected by these tracts.RESULTS: CHR subjects showed significantly higher structural connectivity in the right AF than HC (p < .001). Although non-significant, functional connectivity between cortical areas connected by the AF was lower in CHR than HC (p = .078). Structural and functional connectivity were correlated in HC (p = .056) but not in CHR (p = .29).CONCLUSIONS: We observe significant differences in structural connectivity of the AF, without a concomitant significant change in functional connectivity in CHR subjects. This may suggest that the CHR state is characterised by a decoupling of structural and functional connectivity, possibly due to abnormal white matter maturation.

U2 - 10.1080/15622975.2022.2112974

DO - 10.1080/15622975.2022.2112974

M3 - SCORING: Journal article

C2 - 36083108

VL - 24

SP - 387

EP - 399

JO - WORLD J BIOL PSYCHIA

JF - WORLD J BIOL PSYCHIA

SN - 1562-2975

IS - 5

ER -