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The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study

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The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study. / Müller, Christian P; Chu, Congying; Qin, Liya; Liu, Chunyu; Xu, Bing; Gao, He; Ruggeri, Barbara; Hieber, Saskia; Schneider, Julia; Jia, Tianye; Tay, Nicole; Akira, Shizuo; Satoh, Takashi; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Quinlan, Erin Burke; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Artiges, Eric; Lemaitre, Herve; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Paus, Tomáš; Poustka, Luise; Millenet, Sabina; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Bakalkin, Georgy; Liu, Yun; Desrivières, Sylvane; Elliott, Paul; Eulenburg, Volker; Levy, Daniel; Crews, Fulton; Schumann, Gunter.

in: CEREB CORTEX, Jahrgang 29, Nr. 4, 01.04.2019, S. 1736-1751.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Müller, CP, Chu, C, Qin, L, Liu, C, Xu, B, Gao, H, Ruggeri, B, Hieber, S, Schneider, J, Jia, T, Tay, N, Akira, S, Satoh, T, Banaschewski, T, Bokde, ALW, Bromberg, U, Büchel, C, Quinlan, EB, Flor, H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Martinot, M-LP, Artiges, E, Lemaitre, H, Nees, F, Papadopoulos Orfanos, D, Paus, T, Poustka, L, Millenet, S, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Bakalkin, G, Liu, Y, Desrivières, S, Elliott, P, Eulenburg, V, Levy, D, Crews, F & Schumann, G 2019, 'The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study', CEREB CORTEX, Jg. 29, Nr. 4, S. 1736-1751. https://doi.org/10.1093/cercor/bhy341

APA

Müller, C. P., Chu, C., Qin, L., Liu, C., Xu, B., Gao, H., Ruggeri, B., Hieber, S., Schneider, J., Jia, T., Tay, N., Akira, S., Satoh, T., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Quinlan, E. B., Flor, H., ... Schumann, G. (2019). The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study. CEREB CORTEX, 29(4), 1736-1751. https://doi.org/10.1093/cercor/bhy341

Vancouver

Müller CP, Chu C, Qin L, Liu C, Xu B, Gao H et al. The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study. CEREB CORTEX. 2019 Apr 1;29(4):1736-1751. https://doi.org/10.1093/cercor/bhy341

Bibtex

@article{28f1c1507593482f83fd9be8f9943479,
title = "The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study",
abstract = "Alcohol abuse is a major public health problem worldwide. Understanding the molecular mechanisms that control regular drinking may help to reduce hazards of alcohol consumption. While immunological mechanisms have been related to alcohol drinking, most studies reported changes in immune function that are secondary to alcohol use. In this report, we analyse how the gene {"}TRAF family member-associated NF-κB activator{"} (TANK) affects alcohol drinking behavior. Based on our recent discovery in a large GWAS dataset that suggested an association of TANK, SNP rs197273, with alcohol drinking, we report that SNP rs197273 in TANK is associated both with gene expression (P = 1.16 × 10-19) and regional methylation (P = 5.90 × 10-25). A tank knock out mouse model suggests a role of TANK in alcohol drinking, anxiety-related behavior, as well as alcohol exposure induced activation of insular cortex NF-κB. Functional and structural neuroimaging studies among up to 1896 adolescents reveal that TANK is involved in the control of brain activity in areas of aversive interoceptive processing, including the insular cortex, but not in areas related to reinforcement, reward processing or impulsiveness. Our findings suggest that the cortical neuroimmune regulator TANK is associated with enhanced aversive emotional processing that better protects from the establishment of alcohol drinking behavior.",
author = "M{\"u}ller, {Christian P} and Congying Chu and Liya Qin and Chunyu Liu and Bing Xu and He Gao and Barbara Ruggeri and Saskia Hieber and Julia Schneider and Tianye Jia and Nicole Tay and Shizuo Akira and Takashi Satoh and Tobias Banaschewski and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Quinlan, {Erin Burke} and Herta Flor and Vincent Frouin and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Eric Artiges and Herve Lemaitre and Frauke Nees and {Papadopoulos Orfanos}, Dimitri and Tom{\'a}{\v s} Paus and Luise Poustka and Sabina Millenet and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Georgy Bakalkin and Yun Liu and Sylvane Desrivi{\`e}res and Paul Elliott and Volker Eulenburg and Daniel Levy and Fulton Crews and Gunter Schumann",
note = "{\textcopyright} The Author(s) 2019. Published by Oxford University Press.",
year = "2019",
month = apr,
day = "1",
doi = "10.1093/cercor/bhy341",
language = "English",
volume = "29",
pages = "1736--1751",
journal = "CEREB CORTEX",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study

AU - Müller, Christian P

AU - Chu, Congying

AU - Qin, Liya

AU - Liu, Chunyu

AU - Xu, Bing

AU - Gao, He

AU - Ruggeri, Barbara

AU - Hieber, Saskia

AU - Schneider, Julia

AU - Jia, Tianye

AU - Tay, Nicole

AU - Akira, Shizuo

AU - Satoh, Takashi

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Quinlan, Erin Burke

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Artiges, Eric

AU - Lemaitre, Herve

AU - Nees, Frauke

AU - Papadopoulos Orfanos, Dimitri

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Millenet, Sabina

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Bakalkin, Georgy

AU - Liu, Yun

AU - Desrivières, Sylvane

AU - Elliott, Paul

AU - Eulenburg, Volker

AU - Levy, Daniel

AU - Crews, Fulton

AU - Schumann, Gunter

N1 - © The Author(s) 2019. Published by Oxford University Press.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Alcohol abuse is a major public health problem worldwide. Understanding the molecular mechanisms that control regular drinking may help to reduce hazards of alcohol consumption. While immunological mechanisms have been related to alcohol drinking, most studies reported changes in immune function that are secondary to alcohol use. In this report, we analyse how the gene "TRAF family member-associated NF-κB activator" (TANK) affects alcohol drinking behavior. Based on our recent discovery in a large GWAS dataset that suggested an association of TANK, SNP rs197273, with alcohol drinking, we report that SNP rs197273 in TANK is associated both with gene expression (P = 1.16 × 10-19) and regional methylation (P = 5.90 × 10-25). A tank knock out mouse model suggests a role of TANK in alcohol drinking, anxiety-related behavior, as well as alcohol exposure induced activation of insular cortex NF-κB. Functional and structural neuroimaging studies among up to 1896 adolescents reveal that TANK is involved in the control of brain activity in areas of aversive interoceptive processing, including the insular cortex, but not in areas related to reinforcement, reward processing or impulsiveness. Our findings suggest that the cortical neuroimmune regulator TANK is associated with enhanced aversive emotional processing that better protects from the establishment of alcohol drinking behavior.

AB - Alcohol abuse is a major public health problem worldwide. Understanding the molecular mechanisms that control regular drinking may help to reduce hazards of alcohol consumption. While immunological mechanisms have been related to alcohol drinking, most studies reported changes in immune function that are secondary to alcohol use. In this report, we analyse how the gene "TRAF family member-associated NF-κB activator" (TANK) affects alcohol drinking behavior. Based on our recent discovery in a large GWAS dataset that suggested an association of TANK, SNP rs197273, with alcohol drinking, we report that SNP rs197273 in TANK is associated both with gene expression (P = 1.16 × 10-19) and regional methylation (P = 5.90 × 10-25). A tank knock out mouse model suggests a role of TANK in alcohol drinking, anxiety-related behavior, as well as alcohol exposure induced activation of insular cortex NF-κB. Functional and structural neuroimaging studies among up to 1896 adolescents reveal that TANK is involved in the control of brain activity in areas of aversive interoceptive processing, including the insular cortex, but not in areas related to reinforcement, reward processing or impulsiveness. Our findings suggest that the cortical neuroimmune regulator TANK is associated with enhanced aversive emotional processing that better protects from the establishment of alcohol drinking behavior.

U2 - 10.1093/cercor/bhy341

DO - 10.1093/cercor/bhy341

M3 - SCORING: Journal article

C2 - 30721969

VL - 29

SP - 1736

EP - 1751

JO - CEREB CORTEX

JF - CEREB CORTEX

SN - 1047-3211

IS - 4

ER -