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The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk

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The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk. / Becker, Jessica; May, Andrea; Gerges, Christian; Anders, Mario; Schmidt, Claudia; Veits, Lothar; Noder, Tania; Mayershofer, Rupert; Kreuser, Nicole; Manner, Hendrik; Venerito, Marino; Hofer, Jan-Hinnerk; Lyros, Orestis; Ahlbrand, Constantin J; Arras, Michael; Hofer, Sebastian; Heinrichs, Sophie K M; Weise, Katharina; Hess, Timo; Böhmer, Anne C; Kosiol, Nils; Kiesslich, Ralf; Izbicki, Jakob R; Hölscher, Arnulf H; Bollschweiler, Elfriede; Malfertheiner, Peter; Lang, Hauke; Moehler, Markus; Lorenz, Dietmar; Ott, Katja; Schmidt, Thomas; Nöthen, Markus M; Hackelsberger, Andreas; Schumacher, Brigitte; Pech, Oliver; Vashist, Yogesh; Vieth, Michael; Weismüller, Josef; Knapp, Michael; Neuhaus, Horst; Rösch, Thomas; Ell, Christian; Gockel, Ines; Schumacher, Johannes.

in: CANCER MED-US, Jahrgang 5, Nr. 5, 05.2016, S. 888-91.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Becker, J, May, A, Gerges, C, Anders, M, Schmidt, C, Veits, L, Noder, T, Mayershofer, R, Kreuser, N, Manner, H, Venerito, M, Hofer, J-H, Lyros, O, Ahlbrand, CJ, Arras, M, Hofer, S, Heinrichs, SKM, Weise, K, Hess, T, Böhmer, AC, Kosiol, N, Kiesslich, R, Izbicki, JR, Hölscher, AH, Bollschweiler, E, Malfertheiner, P, Lang, H, Moehler, M, Lorenz, D, Ott, K, Schmidt, T, Nöthen, MM, Hackelsberger, A, Schumacher, B, Pech, O, Vashist, Y, Vieth, M, Weismüller, J, Knapp, M, Neuhaus, H, Rösch, T, Ell, C, Gockel, I & Schumacher, J 2016, 'The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk', CANCER MED-US, Jg. 5, Nr. 5, S. 888-91. https://doi.org/10.1002/cam4.641

APA

Becker, J., May, A., Gerges, C., Anders, M., Schmidt, C., Veits, L., Noder, T., Mayershofer, R., Kreuser, N., Manner, H., Venerito, M., Hofer, J-H., Lyros, O., Ahlbrand, C. J., Arras, M., Hofer, S., Heinrichs, S. K. M., Weise, K., Hess, T., ... Schumacher, J. (2016). The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk. CANCER MED-US, 5(5), 888-91. https://doi.org/10.1002/cam4.641

Vancouver

Becker J, May A, Gerges C, Anders M, Schmidt C, Veits L et al. The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk. CANCER MED-US. 2016 Mai;5(5):888-91. https://doi.org/10.1002/cam4.641

Bibtex

@article{bf9c1e1dbb664b02b3f3d8f1ff767bae,
title = "The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk",
abstract = "Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis-metaplasia-dysplasia-adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence. Our data show that rs3072 at GDF7 and rs2701108 at TBX5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE/EAC sequence. In contrast, rs3784262 at ALDH1A2 was highly significantly associated with BE, but showed no association with EAC. Our data do not provide evidence that the ALDH1A2 locus confers equal risk in early and late stages of BE/EAC sequence.",
keywords = "Journal Article",
author = "Jessica Becker and Andrea May and Christian Gerges and Mario Anders and Claudia Schmidt and Lothar Veits and Tania Noder and Rupert Mayershofer and Nicole Kreuser and Hendrik Manner and Marino Venerito and Jan-Hinnerk Hofer and Orestis Lyros and Ahlbrand, {Constantin J} and Michael Arras and Sebastian Hofer and Heinrichs, {Sophie K M} and Katharina Weise and Timo Hess and B{\"o}hmer, {Anne C} and Nils Kosiol and Ralf Kiesslich and Izbicki, {Jakob R} and H{\"o}lscher, {Arnulf H} and Elfriede Bollschweiler and Peter Malfertheiner and Hauke Lang and Markus Moehler and Dietmar Lorenz and Katja Ott and Thomas Schmidt and N{\"o}then, {Markus M} and Andreas Hackelsberger and Brigitte Schumacher and Oliver Pech and Yogesh Vashist and Michael Vieth and Josef Weism{\"u}ller and Michael Knapp and Horst Neuhaus and Thomas R{\"o}sch and Christian Ell and Ines Gockel and Johannes Schumacher",
note = "{\textcopyright} 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.",
year = "2016",
month = may,
doi = "10.1002/cam4.641",
language = "English",
volume = "5",
pages = "888--91",
journal = "CANCER MED-US",
issn = "2045-7634",
publisher = "John Wiley and Sons Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk

AU - Becker, Jessica

AU - May, Andrea

AU - Gerges, Christian

AU - Anders, Mario

AU - Schmidt, Claudia

AU - Veits, Lothar

AU - Noder, Tania

AU - Mayershofer, Rupert

AU - Kreuser, Nicole

AU - Manner, Hendrik

AU - Venerito, Marino

AU - Hofer, Jan-Hinnerk

AU - Lyros, Orestis

AU - Ahlbrand, Constantin J

AU - Arras, Michael

AU - Hofer, Sebastian

AU - Heinrichs, Sophie K M

AU - Weise, Katharina

AU - Hess, Timo

AU - Böhmer, Anne C

AU - Kosiol, Nils

AU - Kiesslich, Ralf

AU - Izbicki, Jakob R

AU - Hölscher, Arnulf H

AU - Bollschweiler, Elfriede

AU - Malfertheiner, Peter

AU - Lang, Hauke

AU - Moehler, Markus

AU - Lorenz, Dietmar

AU - Ott, Katja

AU - Schmidt, Thomas

AU - Nöthen, Markus M

AU - Hackelsberger, Andreas

AU - Schumacher, Brigitte

AU - Pech, Oliver

AU - Vashist, Yogesh

AU - Vieth, Michael

AU - Weismüller, Josef

AU - Knapp, Michael

AU - Neuhaus, Horst

AU - Rösch, Thomas

AU - Ell, Christian

AU - Gockel, Ines

AU - Schumacher, Johannes

N1 - © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

PY - 2016/5

Y1 - 2016/5

N2 - Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis-metaplasia-dysplasia-adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence. Our data show that rs3072 at GDF7 and rs2701108 at TBX5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE/EAC sequence. In contrast, rs3784262 at ALDH1A2 was highly significantly associated with BE, but showed no association with EAC. Our data do not provide evidence that the ALDH1A2 locus confers equal risk in early and late stages of BE/EAC sequence.

AB - Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis-metaplasia-dysplasia-adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence. Our data show that rs3072 at GDF7 and rs2701108 at TBX5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE/EAC sequence. In contrast, rs3784262 at ALDH1A2 was highly significantly associated with BE, but showed no association with EAC. Our data do not provide evidence that the ALDH1A2 locus confers equal risk in early and late stages of BE/EAC sequence.

KW - Journal Article

U2 - 10.1002/cam4.641

DO - 10.1002/cam4.641

M3 - SCORING: Journal article

C2 - 26783083

VL - 5

SP - 888

EP - 891

JO - CANCER MED-US

JF - CANCER MED-US

SN - 2045-7634

IS - 5

ER -