The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort
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The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort. / von Siemens, Sarah Marietta; Perneczky, Robert; Vogelmeier, Claus F; Behr, Jürgen; Kauffmann-Guerrero, Diego; Alter, Peter; Trudzinski, Franziska C; Bals, Robert; Grohé, Christian; Söhler, Sandra; Waschki, Benjamin; Lutter, Johanna I; Welte, Tobias; Jörres, Rudolf A; Kahnert, Kathrin; COSYCONET study group.
in: RESP RES, Jahrgang 20, Nr. 1, 14.11.2019, S. 257.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort
AU - von Siemens, Sarah Marietta
AU - Perneczky, Robert
AU - Vogelmeier, Claus F
AU - Behr, Jürgen
AU - Kauffmann-Guerrero, Diego
AU - Alter, Peter
AU - Trudzinski, Franziska C
AU - Bals, Robert
AU - Grohé, Christian
AU - Söhler, Sandra
AU - Waschki, Benjamin
AU - Lutter, Johanna I
AU - Welte, Tobias
AU - Jörres, Rudolf A
AU - Kahnert, Kathrin
AU - COSYCONET study group
PY - 2019/11/14
Y1 - 2019/11/14
N2 - Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).Data from 1969 COPD patients of the COSYCONET cohort (GOLD grades 1-4; 1216 male/ 753 female; mean (SD) age 64.9 ± 8.4 years) were analysed using regression and path analysis. The DemTect screening tool was used to measure cognitive function, and the St. George's respiratory questionnaire (SGRQ) to assess disease-specific QoL.DemTect scores were < 9 points in 1.6% of patients and < 13 points in 12% when using the original evaluation algorithm distinguishing between < 60 or > =60 years of age. For statistical reasons, we used the average of both algorithms independent of age in all subsequent analyses. The DemTect scores were associated with oxygen content, 6-min-walking distance (6-MWD), C-reactive protein (CRP), modified Medical Research Council dyspnoea scale (mMRC) and the SGRQ impact score. Conversely, the SGRQ impact score was independently associated with 6-MWD, FVC, mMRC and DemTect. These results were combined into a path analysis model to account for direct and indirect effects. The DemTect score had a small, but independent impact on QoL, irrespective of the inclusion of COPD-specific influencing factors or a diagnosis of cognitive impairment.We conclude that in patients with stable COPD lower oxygen content of blood as a measure of peripheral oxygen supply, lower exercise capacity in terms of 6-MWD, and higher CRP levels were associated with reduced cognitive capacity. Furthermore, a reduction in cognitive capacity was associated with reduced disease-specific quality of life. As a potential clinical implication of this work, we suggest to screen especially patients with low oxygen content and low 6-MWD for cognitive impairment.
AB - Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).Data from 1969 COPD patients of the COSYCONET cohort (GOLD grades 1-4; 1216 male/ 753 female; mean (SD) age 64.9 ± 8.4 years) were analysed using regression and path analysis. The DemTect screening tool was used to measure cognitive function, and the St. George's respiratory questionnaire (SGRQ) to assess disease-specific QoL.DemTect scores were < 9 points in 1.6% of patients and < 13 points in 12% when using the original evaluation algorithm distinguishing between < 60 or > =60 years of age. For statistical reasons, we used the average of both algorithms independent of age in all subsequent analyses. The DemTect scores were associated with oxygen content, 6-min-walking distance (6-MWD), C-reactive protein (CRP), modified Medical Research Council dyspnoea scale (mMRC) and the SGRQ impact score. Conversely, the SGRQ impact score was independently associated with 6-MWD, FVC, mMRC and DemTect. These results were combined into a path analysis model to account for direct and indirect effects. The DemTect score had a small, but independent impact on QoL, irrespective of the inclusion of COPD-specific influencing factors or a diagnosis of cognitive impairment.We conclude that in patients with stable COPD lower oxygen content of blood as a measure of peripheral oxygen supply, lower exercise capacity in terms of 6-MWD, and higher CRP levels were associated with reduced cognitive capacity. Furthermore, a reduction in cognitive capacity was associated with reduced disease-specific quality of life. As a potential clinical implication of this work, we suggest to screen especially patients with low oxygen content and low 6-MWD for cognitive impairment.
KW - Aged
KW - Cognition/physiology
KW - Cognitive Dysfunction/diagnosis
KW - Cohort Studies
KW - Comorbidity
KW - Cross-Sectional Studies
KW - Female
KW - Humans
KW - Male
KW - Mental Status and Dementia Tests
KW - Middle Aged
KW - Pulmonary Disease, Chronic Obstructive/diagnosis
KW - Surveys and Questionnaires
U2 - 10.1186/s12931-019-1217-5
DO - 10.1186/s12931-019-1217-5
M3 - SCORING: Journal article
C2 - 31727165
VL - 20
SP - 257
JO - RESP RES
JF - RESP RES
SN - 1465-993X
IS - 1
ER -