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The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability.

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The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability. / Cour, La; Jonas, M; Høj, Berit R; Simon, Ronald; Sauter, Guido; Sauter, Guido; Berchtold, Martin W.

in: MOL ONCOL, Jahrgang 1, Nr. 4, 4, 2008, S. 431-439.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Cour, L, Jonas, M, Høj, BR, Simon, R, Sauter, G, Sauter, G & Berchtold, MW 2008, 'The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability.', MOL ONCOL, Jg. 1, Nr. 4, 4, S. 431-439. https://doi.org/10.1016/j.molonc.2007.08.002

APA

Cour, L., Jonas, M., Høj, B. R., Simon, R., Sauter, G., Sauter, G., & Berchtold, M. W. (2008). The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability. MOL ONCOL, 1(4), 431-439. [4]. https://doi.org/10.1016/j.molonc.2007.08.002

Vancouver

Cour L, Jonas M, Høj BR, Simon R, Sauter G, Sauter G et al. The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability. MOL ONCOL. 2008;1(4):431-439. 4. https://doi.org/10.1016/j.molonc.2007.08.002

Bibtex

@article{b33e75ca5552401c809e3b2e2845d3c8,
title = "The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability.",
abstract = "The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.",
author = "La Cour and M Jonas and H{\o}j, {Berit R} and Ronald Simon and Guido Sauter and Guido Sauter and Berchtold, {Martin W}",
year = "2008",
doi = "10.1016/j.molonc.2007.08.002",
language = "Deutsch",
volume = "1",
pages = "431--439",
journal = "MOL ONCOL",
issn = "1574-7891",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability.

AU - Cour, La

AU - Jonas, M

AU - Høj, Berit R

AU - Simon, Ronald

AU - Sauter, Guido

AU - Sauter, Guido

AU - Berchtold, Martin W

PY - 2008

Y1 - 2008

N2 - The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.

AB - The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.

U2 - 10.1016/j.molonc.2007.08.002

DO - 10.1016/j.molonc.2007.08.002

M3 - SCORING: Zeitschriftenaufsatz

VL - 1

SP - 431

EP - 439

JO - MOL ONCOL

JF - MOL ONCOL

SN - 1574-7891

IS - 4

M1 - 4

ER -