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The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus)

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The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus). / Fedorov, Sergey; Dyshlovoy, Sergey; Monastyrnaya, Margarita; Shubina, Larisa; Leychenko, Elena; Kozlovskaya, Emma; Jin, Jun O.; Kwak, Jong Young; Bode, Ann M.; Dong, Zigang; Stonik, Valentin.

in: TOXICON, Jahrgang 55, Nr. 4, 01.04.2010, S. 811-817.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fedorov, S, Dyshlovoy, S, Monastyrnaya, M, Shubina, L, Leychenko, E, Kozlovskaya, E, Jin, JO, Kwak, JY, Bode, AM, Dong, Z & Stonik, V 2010, 'The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus)', TOXICON, Jg. 55, Nr. 4, S. 811-817. https://doi.org/10.1016/j.toxicon.2009.11.016

APA

Fedorov, S., Dyshlovoy, S., Monastyrnaya, M., Shubina, L., Leychenko, E., Kozlovskaya, E., Jin, J. O., Kwak, J. Y., Bode, A. M., Dong, Z., & Stonik, V. (2010). The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus). TOXICON, 55(4), 811-817. https://doi.org/10.1016/j.toxicon.2009.11.016

Vancouver

Fedorov S, Dyshlovoy S, Monastyrnaya M, Shubina L, Leychenko E, Kozlovskaya E et al. The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus). TOXICON. 2010 Apr 1;55(4):811-817. https://doi.org/10.1016/j.toxicon.2009.11.016

Bibtex

@article{844eac43b0004de1a94aa4c8e3c17f2d,
title = "The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus)",
abstract = "Four isoforms of actinoporins were isolated in 2002-2004 from the tropical sea anemone Heteractis crispa (=Radianthus macrodactylus). Their potent hemolytic activities and effects on Ehrlich ascites carcinoma bearing mice were also studied. In this study, the individual actinoporin (RTX-A) demonstrated potential cancer-preventive activity at extremely low and non-cytotoxic concentrations. The substance suppressed the malignant transformation of mouse JB6 P + Cl41 cells stimulated by epidermal growth factor (EGF) in soft agar with the inhibition of number of the colonies C 50 (INCC 50)=0.034nM. Actinoporin RTX-A also was shown to inhibit the phenotype expression of HeLa human cancer cells with an INCC 50=0.03nM. The cytotoxic effect of RTX-A against JB6 P + Cl41 cells and HeLa, THP-1, MDA-MB-231, and SNU-C4 human tumor cell lines was high (IC 50=0.57, 2.26, 1.11, 30.0 and 4.66nM), but significantly less than their capacity to suppress tumor cell colony formation or phenotype expression. RTX-A also induced apoptosis and inhibited basal AP-1, NF-κB, and p53-dependent transcriptional activity in JB6 Cl41 cells. These results confirmed that actinoporin RTX-A from H. crispa, at least partially, might exhibit cancer-preventive and anticancer cytotoxic properties through the induction of p53-independent apoptosis and inhibition of the oncogenic AP-1 and NF-κB nuclear factors activity.",
keywords = "Actinoporin, Anticancer activity, AP-1, Apoptosis, Inhibition of malignant transformation, NF-κB, P53 nuclear factors",
author = "Sergey Fedorov and Sergey Dyshlovoy and Margarita Monastyrnaya and Larisa Shubina and Elena Leychenko and Emma Kozlovskaya and Jin, {Jun O.} and Kwak, {Jong Young} and Bode, {Ann M.} and Zigang Dong and Valentin Stonik",
note = "Funding Information: This work was supported in part by The Hormel Foundation and National Institutes of Health grants CA81064, CA77646 and CA88961; by the Grant 2813.2008.4 for Support of the Leading Russian Science Schools, Program of Presidium of RAS “Molecular and Cell Biology” 09-I-Π22-05 and 09-I-Π22-06, Grant RFBR 08-04-01052-a and FEB RAS Grants 09-III-B-05-155, 09-III-A-05-146, 09-III-A-05-141. The Korean co-authors are grateful for financial support from the National Research Foundation of Korea (NRF) (No. R13-2002-044-04001-0). Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",
year = "2010",
month = apr,
day = "1",
doi = "10.1016/j.toxicon.2009.11.016",
language = "English",
volume = "55",
pages = "811--817",
journal = "TOXICON",
issn = "0041-0101",
publisher = "Elsevier Limited",
number = "4",

}

RIS

TY - JOUR

T1 - The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus)

AU - Fedorov, Sergey

AU - Dyshlovoy, Sergey

AU - Monastyrnaya, Margarita

AU - Shubina, Larisa

AU - Leychenko, Elena

AU - Kozlovskaya, Emma

AU - Jin, Jun O.

AU - Kwak, Jong Young

AU - Bode, Ann M.

AU - Dong, Zigang

AU - Stonik, Valentin

N1 - Funding Information: This work was supported in part by The Hormel Foundation and National Institutes of Health grants CA81064, CA77646 and CA88961; by the Grant 2813.2008.4 for Support of the Leading Russian Science Schools, Program of Presidium of RAS “Molecular and Cell Biology” 09-I-Π22-05 and 09-I-Π22-06, Grant RFBR 08-04-01052-a and FEB RAS Grants 09-III-B-05-155, 09-III-A-05-146, 09-III-A-05-141. The Korean co-authors are grateful for financial support from the National Research Foundation of Korea (NRF) (No. R13-2002-044-04001-0). Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Four isoforms of actinoporins were isolated in 2002-2004 from the tropical sea anemone Heteractis crispa (=Radianthus macrodactylus). Their potent hemolytic activities and effects on Ehrlich ascites carcinoma bearing mice were also studied. In this study, the individual actinoporin (RTX-A) demonstrated potential cancer-preventive activity at extremely low and non-cytotoxic concentrations. The substance suppressed the malignant transformation of mouse JB6 P + Cl41 cells stimulated by epidermal growth factor (EGF) in soft agar with the inhibition of number of the colonies C 50 (INCC 50)=0.034nM. Actinoporin RTX-A also was shown to inhibit the phenotype expression of HeLa human cancer cells with an INCC 50=0.03nM. The cytotoxic effect of RTX-A against JB6 P + Cl41 cells and HeLa, THP-1, MDA-MB-231, and SNU-C4 human tumor cell lines was high (IC 50=0.57, 2.26, 1.11, 30.0 and 4.66nM), but significantly less than their capacity to suppress tumor cell colony formation or phenotype expression. RTX-A also induced apoptosis and inhibited basal AP-1, NF-κB, and p53-dependent transcriptional activity in JB6 Cl41 cells. These results confirmed that actinoporin RTX-A from H. crispa, at least partially, might exhibit cancer-preventive and anticancer cytotoxic properties through the induction of p53-independent apoptosis and inhibition of the oncogenic AP-1 and NF-κB nuclear factors activity.

AB - Four isoforms of actinoporins were isolated in 2002-2004 from the tropical sea anemone Heteractis crispa (=Radianthus macrodactylus). Their potent hemolytic activities and effects on Ehrlich ascites carcinoma bearing mice were also studied. In this study, the individual actinoporin (RTX-A) demonstrated potential cancer-preventive activity at extremely low and non-cytotoxic concentrations. The substance suppressed the malignant transformation of mouse JB6 P + Cl41 cells stimulated by epidermal growth factor (EGF) in soft agar with the inhibition of number of the colonies C 50 (INCC 50)=0.034nM. Actinoporin RTX-A also was shown to inhibit the phenotype expression of HeLa human cancer cells with an INCC 50=0.03nM. The cytotoxic effect of RTX-A against JB6 P + Cl41 cells and HeLa, THP-1, MDA-MB-231, and SNU-C4 human tumor cell lines was high (IC 50=0.57, 2.26, 1.11, 30.0 and 4.66nM), but significantly less than their capacity to suppress tumor cell colony formation or phenotype expression. RTX-A also induced apoptosis and inhibited basal AP-1, NF-κB, and p53-dependent transcriptional activity in JB6 Cl41 cells. These results confirmed that actinoporin RTX-A from H. crispa, at least partially, might exhibit cancer-preventive and anticancer cytotoxic properties through the induction of p53-independent apoptosis and inhibition of the oncogenic AP-1 and NF-κB nuclear factors activity.

KW - Actinoporin

KW - Anticancer activity

KW - AP-1

KW - Apoptosis

KW - Inhibition of malignant transformation

KW - NF-κB

KW - P53 nuclear factors

UR - http://www.scopus.com/inward/record.url?scp=77953373957&partnerID=8YFLogxK

U2 - 10.1016/j.toxicon.2009.11.016

DO - 10.1016/j.toxicon.2009.11.016

M3 - SCORING: Journal article

C2 - 19944712

AN - SCOPUS:77953373957

VL - 55

SP - 811

EP - 817

JO - TOXICON

JF - TOXICON

SN - 0041-0101

IS - 4

ER -