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The additive prognostic value of coronary calcium score (CCS) to single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI)-real world data from a single center

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The additive prognostic value of coronary calcium score (CCS) to single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI)-real world data from a single center. / Sharma, Vinoda; Mughal, Lal; Dimitropoulos, Gerasimos; Sheikh, Awais; Griffin, Michael; Moss, Alexandra; Notghi, Alp; Pandit, Manish; Connolly, Derek L; Varma, Chetan; Kirchhof, Paulus.

in: J NUCL CARDIOL, Jahrgang 28, Nr. 5, 10.2021, S. 2086-2096.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sharma, V, Mughal, L, Dimitropoulos, G, Sheikh, A, Griffin, M, Moss, A, Notghi, A, Pandit, M, Connolly, DL, Varma, C & Kirchhof, P 2021, 'The additive prognostic value of coronary calcium score (CCS) to single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI)-real world data from a single center', J NUCL CARDIOL, Jg. 28, Nr. 5, S. 2086-2096. https://doi.org/10.1007/s12350-019-01965-9

APA

Sharma, V., Mughal, L., Dimitropoulos, G., Sheikh, A., Griffin, M., Moss, A., Notghi, A., Pandit, M., Connolly, D. L., Varma, C., & Kirchhof, P. (2021). The additive prognostic value of coronary calcium score (CCS) to single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI)-real world data from a single center. J NUCL CARDIOL, 28(5), 2086-2096. https://doi.org/10.1007/s12350-019-01965-9

Vancouver

Sharma V, Mughal L, Dimitropoulos G, Sheikh A, Griffin M, Moss A et al. The additive prognostic value of coronary calcium score (CCS) to single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI)-real world data from a single center. J NUCL CARDIOL. 2021 Okt;28(5):2086-2096. https://doi.org/10.1007/s12350-019-01965-9

Bibtex

@article{f88f3b73ca294a2087848b2884bb3cae,
title = "The additive prognostic value of coronary calcium score (CCS) to single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI)-real world data from a single center",
abstract = "AIMS: Single-photon emission computed tomography myocardial perfusion imaging [SPECT-MPI] is a functional test for coronary ischemia. We aimed to assess the additive prognostic value of coronary calcium score (CCS) to SPECT-MPI in stable patients.METHODS: This study is a retrospective analysis of 655 patients who underwent SPECT-MPI with CCS (2012 to 2017). Receiver operator characteristic (ROC) identified CCS cutoff value for all-cause mortality: CCS+ if > cutoff value and MPI+ if ≥ 5% total perfusion defect (TPD). Patients were divided into 1 MPI-/CCS-; 2 MPI+/CCS-; 3 MPI-/CCS+; 4 MPI+/CCS+ and compared. Cox proportional hazard analysis identified predictors of mortality.RESULTS: CCS cutoff for all-cause mortality was > 216 (C statistic 0.756, P < 0.0001). In MPI+ groups, mean TPD was similar (13.4% and 13.1% respectively) but mortality was higher in the CCS+ (12.5% vs. 4.8%, P = 0.22) as was the severe LV systolic dysfunction (8.0% vs. 0%, P = 0.095). In MPI- groups, mean TPD was similar (0.7% and 0.9% respectively) but all-cause mortality was higher in the CCS+ (10.7% vs. 1.6%, P < 0.0001) as was severe LVSD (2.9 % vs. 0.3% P = 0.016). Age, smoking, renal impairment ,and CCS > 216 were independent predictors of mortality.CONCLUSIONS: Patients with raised CCS on SPECT-MPI have increased mortality and poor LV function despite a negative MPI.",
author = "Vinoda Sharma and Lal Mughal and Gerasimos Dimitropoulos and Awais Sheikh and Michael Griffin and Alexandra Moss and Alp Notghi and Manish Pandit and Connolly, {Derek L} and Chetan Varma and Paulus Kirchhof",
note = "{\textcopyright} 2019. American Society of Nuclear Cardiology.",
year = "2021",
month = oct,
doi = "10.1007/s12350-019-01965-9",
language = "English",
volume = "28",
pages = "2086--2096",
journal = "J NUCL CARDIOL",
issn = "1071-3581",
publisher = "Springer New York",
number = "5",

}

RIS

TY - JOUR

T1 - The additive prognostic value of coronary calcium score (CCS) to single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI)-real world data from a single center

AU - Sharma, Vinoda

AU - Mughal, Lal

AU - Dimitropoulos, Gerasimos

AU - Sheikh, Awais

AU - Griffin, Michael

AU - Moss, Alexandra

AU - Notghi, Alp

AU - Pandit, Manish

AU - Connolly, Derek L

AU - Varma, Chetan

AU - Kirchhof, Paulus

N1 - © 2019. American Society of Nuclear Cardiology.

PY - 2021/10

Y1 - 2021/10

N2 - AIMS: Single-photon emission computed tomography myocardial perfusion imaging [SPECT-MPI] is a functional test for coronary ischemia. We aimed to assess the additive prognostic value of coronary calcium score (CCS) to SPECT-MPI in stable patients.METHODS: This study is a retrospective analysis of 655 patients who underwent SPECT-MPI with CCS (2012 to 2017). Receiver operator characteristic (ROC) identified CCS cutoff value for all-cause mortality: CCS+ if > cutoff value and MPI+ if ≥ 5% total perfusion defect (TPD). Patients were divided into 1 MPI-/CCS-; 2 MPI+/CCS-; 3 MPI-/CCS+; 4 MPI+/CCS+ and compared. Cox proportional hazard analysis identified predictors of mortality.RESULTS: CCS cutoff for all-cause mortality was > 216 (C statistic 0.756, P < 0.0001). In MPI+ groups, mean TPD was similar (13.4% and 13.1% respectively) but mortality was higher in the CCS+ (12.5% vs. 4.8%, P = 0.22) as was the severe LV systolic dysfunction (8.0% vs. 0%, P = 0.095). In MPI- groups, mean TPD was similar (0.7% and 0.9% respectively) but all-cause mortality was higher in the CCS+ (10.7% vs. 1.6%, P < 0.0001) as was severe LVSD (2.9 % vs. 0.3% P = 0.016). Age, smoking, renal impairment ,and CCS > 216 were independent predictors of mortality.CONCLUSIONS: Patients with raised CCS on SPECT-MPI have increased mortality and poor LV function despite a negative MPI.

AB - AIMS: Single-photon emission computed tomography myocardial perfusion imaging [SPECT-MPI] is a functional test for coronary ischemia. We aimed to assess the additive prognostic value of coronary calcium score (CCS) to SPECT-MPI in stable patients.METHODS: This study is a retrospective analysis of 655 patients who underwent SPECT-MPI with CCS (2012 to 2017). Receiver operator characteristic (ROC) identified CCS cutoff value for all-cause mortality: CCS+ if > cutoff value and MPI+ if ≥ 5% total perfusion defect (TPD). Patients were divided into 1 MPI-/CCS-; 2 MPI+/CCS-; 3 MPI-/CCS+; 4 MPI+/CCS+ and compared. Cox proportional hazard analysis identified predictors of mortality.RESULTS: CCS cutoff for all-cause mortality was > 216 (C statistic 0.756, P < 0.0001). In MPI+ groups, mean TPD was similar (13.4% and 13.1% respectively) but mortality was higher in the CCS+ (12.5% vs. 4.8%, P = 0.22) as was the severe LV systolic dysfunction (8.0% vs. 0%, P = 0.095). In MPI- groups, mean TPD was similar (0.7% and 0.9% respectively) but all-cause mortality was higher in the CCS+ (10.7% vs. 1.6%, P < 0.0001) as was severe LVSD (2.9 % vs. 0.3% P = 0.016). Age, smoking, renal impairment ,and CCS > 216 were independent predictors of mortality.CONCLUSIONS: Patients with raised CCS on SPECT-MPI have increased mortality and poor LV function despite a negative MPI.

U2 - 10.1007/s12350-019-01965-9

DO - 10.1007/s12350-019-01965-9

M3 - SCORING: Journal article

C2 - 31797319

VL - 28

SP - 2086

EP - 2096

JO - J NUCL CARDIOL

JF - J NUCL CARDIOL

SN - 1071-3581

IS - 5

ER -