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The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure.

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The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure. / Leist, M; Gantner, F; Künstle, G; Bohlinger, I; Tiegs, Gisa; Bluethmann, H; Wendel, A.

in: MOL MED, Jahrgang 2, Nr. 1, 1, 1996, S. 109-124.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Leist, M, Gantner, F, Künstle, G, Bohlinger, I, Tiegs, G, Bluethmann, H & Wendel, A 1996, 'The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure.', MOL MED, Jg. 2, Nr. 1, 1, S. 109-124. <http://www.ncbi.nlm.nih.gov/pubmed/8900539?dopt=Citation>

APA

Leist, M., Gantner, F., Künstle, G., Bohlinger, I., Tiegs, G., Bluethmann, H., & Wendel, A. (1996). The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure. MOL MED, 2(1), 109-124. [1]. http://www.ncbi.nlm.nih.gov/pubmed/8900539?dopt=Citation

Vancouver

Leist M, Gantner F, Künstle G, Bohlinger I, Tiegs G, Bluethmann H et al. The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure. MOL MED. 1996;2(1):109-124. 1.

Bibtex

@article{064f864f8b4540c7b8c219f56df9c1ef,
title = "The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure.",
abstract = "Activation of either the 55-kD tumor necrosis factor receptor (TNF-R1) or CD95 (Fas/Apo-1) causes apoptosis of cells and liver failure in mice, and has been associated with human liver disorders. The aim of this study was first to clarify the association between CD95 activation, hepatocyte apoptosis, and fulminant liver failure. Next, we investigated whether TNF-R1 and CD95 operate independently of each other in the induction of hepatocyte apoptosis.",
keywords = "Animals, Cells, Cultured, Mice, Mice, Inbred BALB C, Models, Biological, Gene Expression/genetics, Oxygen/metabolism, Antibodies/immunology/pharmacology, Galactosamine/pharmacology, Concanavalin A/pharmacology, Tumor Necrosis Factor-alpha/pharmacology, Alanine Transaminase/blood/metabolism, Antigens, CD95/immunology/*metabolism/pharmacology, Apoptosis/*genetics, DNA Damage/drug effects/genetics, Dactinomycin/pharmacology, Electrophoresis, Agar Gel, L-Lactate Dehydrogenase/metabolism, Liver/cytology/injuries/*metabolism, Lymphotoxin-alpha/pharmacology, Receptors, Tumor Necrosis Factor/deficiency/*metabolism, Animals, Cells, Cultured, Mice, Mice, Inbred BALB C, Models, Biological, Gene Expression/genetics, Oxygen/metabolism, Antibodies/immunology/pharmacology, Galactosamine/pharmacology, Concanavalin A/pharmacology, Tumor Necrosis Factor-alpha/pharmacology, Alanine Transaminase/blood/metabolism, Antigens, CD95/immunology/*metabolism/pharmacology, Apoptosis/*genetics, DNA Damage/drug effects/genetics, Dactinomycin/pharmacology, Electrophoresis, Agar Gel, L-Lactate Dehydrogenase/metabolism, Liver/cytology/injuries/*metabolism, Lymphotoxin-alpha/pharmacology, Receptors, Tumor Necrosis Factor/deficiency/*metabolism",
author = "M Leist and F Gantner and G K{\"u}nstle and I Bohlinger and Gisa Tiegs and H Bluethmann and A Wendel",
year = "1996",
language = "English",
volume = "2",
pages = "109--124",
journal = "MOL MED",
issn = "1076-1551",
publisher = "Feinstein Institute for Medical Research",
number = "1",

}

RIS

TY - JOUR

T1 - The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure.

AU - Leist, M

AU - Gantner, F

AU - Künstle, G

AU - Bohlinger, I

AU - Tiegs, Gisa

AU - Bluethmann, H

AU - Wendel, A

PY - 1996

Y1 - 1996

N2 - Activation of either the 55-kD tumor necrosis factor receptor (TNF-R1) or CD95 (Fas/Apo-1) causes apoptosis of cells and liver failure in mice, and has been associated with human liver disorders. The aim of this study was first to clarify the association between CD95 activation, hepatocyte apoptosis, and fulminant liver failure. Next, we investigated whether TNF-R1 and CD95 operate independently of each other in the induction of hepatocyte apoptosis.

AB - Activation of either the 55-kD tumor necrosis factor receptor (TNF-R1) or CD95 (Fas/Apo-1) causes apoptosis of cells and liver failure in mice, and has been associated with human liver disorders. The aim of this study was first to clarify the association between CD95 activation, hepatocyte apoptosis, and fulminant liver failure. Next, we investigated whether TNF-R1 and CD95 operate independently of each other in the induction of hepatocyte apoptosis.

KW - Animals

KW - Cells, Cultured

KW - Mice

KW - Mice, Inbred BALB C

KW - Models, Biological

KW - Gene Expression/genetics

KW - Oxygen/metabolism

KW - Antibodies/immunology/pharmacology

KW - Galactosamine/pharmacology

KW - Concanavalin A/pharmacology

KW - Tumor Necrosis Factor-alpha/pharmacology

KW - Alanine Transaminase/blood/metabolism

KW - Antigens, CD95/immunology/metabolism/pharmacology

KW - Apoptosis/genetics

KW - DNA Damage/drug effects/genetics

KW - Dactinomycin/pharmacology

KW - Electrophoresis, Agar Gel

KW - L-Lactate Dehydrogenase/metabolism

KW - Liver/cytology/injuries/metabolism

KW - Lymphotoxin-alpha/pharmacology

KW - Receptors, Tumor Necrosis Factor/deficiency/metabolism

KW - Animals

KW - Cells, Cultured

KW - Mice

KW - Mice, Inbred BALB C

KW - Models, Biological

KW - Gene Expression/genetics

KW - Oxygen/metabolism

KW - Antibodies/immunology/pharmacology

KW - Galactosamine/pharmacology

KW - Concanavalin A/pharmacology

KW - Tumor Necrosis Factor-alpha/pharmacology

KW - Alanine Transaminase/blood/metabolism

KW - Antigens, CD95/immunology/metabolism/pharmacology

KW - Apoptosis/genetics

KW - DNA Damage/drug effects/genetics

KW - Dactinomycin/pharmacology

KW - Electrophoresis, Agar Gel

KW - L-Lactate Dehydrogenase/metabolism

KW - Liver/cytology/injuries/metabolism

KW - Lymphotoxin-alpha/pharmacology

KW - Receptors, Tumor Necrosis Factor/deficiency/metabolism

M3 - SCORING: Journal article

VL - 2

SP - 109

EP - 124

JO - MOL MED

JF - MOL MED

SN - 1076-1551

IS - 1

M1 - 1

ER -