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TH17/IL23 cytokine gene polymorphisms in bullous pemphigoid

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TH17/IL23 cytokine gene polymorphisms in bullous pemphigoid. / Tabatabaei-Panah, Pardis-Sadat; Moravvej, Hamideh; Aghaei, Sahel; Akbari, Maryam; Rajabi, Sakineh; Kia, Atena; Ebrahimi, Elaheh; Sadaf, Zahra; Atoon, Alireza; Behravesh, Nasim; Ludwig, Ralf J; Akbarzadeh, Reza.

in: MOL GENET GENOM MED, Jahrgang 8, Nr. 12, e1519, 12.2020.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tabatabaei-Panah, P-S, Moravvej, H, Aghaei, S, Akbari, M, Rajabi, S, Kia, A, Ebrahimi, E, Sadaf, Z, Atoon, A, Behravesh, N, Ludwig, RJ & Akbarzadeh, R 2020, 'TH17/IL23 cytokine gene polymorphisms in bullous pemphigoid', MOL GENET GENOM MED, Jg. 8, Nr. 12, e1519. https://doi.org/10.1002/mgg3.1519

APA

Tabatabaei-Panah, P-S., Moravvej, H., Aghaei, S., Akbari, M., Rajabi, S., Kia, A., Ebrahimi, E., Sadaf, Z., Atoon, A., Behravesh, N., Ludwig, R. J., & Akbarzadeh, R. (2020). TH17/IL23 cytokine gene polymorphisms in bullous pemphigoid. MOL GENET GENOM MED, 8(12), [e1519]. https://doi.org/10.1002/mgg3.1519

Vancouver

Tabatabaei-Panah P-S, Moravvej H, Aghaei S, Akbari M, Rajabi S, Kia A et al. TH17/IL23 cytokine gene polymorphisms in bullous pemphigoid. MOL GENET GENOM MED. 2020 Dez;8(12). e1519. https://doi.org/10.1002/mgg3.1519

Bibtex

@article{a0b75cca77714d2e9162af83e3d30a93,
title = "TH17/IL23 cytokine gene polymorphisms in bullous pemphigoid",
abstract = "BACKGROUND: TH17/IL-23 immune axis is considered to be involved in the pathogenesis of autoimmune and chronic inflammatory diseases. Bullous pemphigoid (BP) is the most frequent autoimmune blistering disease, characterized by the presence of autoantibodies against the components of the dermal-epidermal junction. Animal studies and characterization of patient samples point toward a contribution of TH17 cells in BP pathogenesis. However, genetic polymorphisms in the genes of TH17/IL-23 cytokines have not yet been well investigated in BP.METHODS: Detection of polymorphisms in IL-17A (rs2275913 and rs3819025), IL-17F (rs2397084 and rs763780), IL-17RA (rs2229151), and IL-23R (rs2201841, rs7530511, rs11209026, and rs10889677) genes were performed following the collection of blood samples and DNA extraction from BP patients and controls. Gene expression of IL-23R was determined by quantitative RT-PCR analysis.RESULTS: The prevalence of IL-23R rs7530511 genotypes and alleles, as well as IL-23R rs2201841 alleles, is significantly different between the BP patients and controls. While the minor C-allele of IL-23R rs7530511 is highly present in the patients, the G-allele distribution of IL-23R rs2201841 is significantly more prevalent in the control individuals compared to the BP patients. Genotypes and alleles of other SNPs in IL-17A, IL-17F, and IL-17RA were similarly distributed in patients and controls.CONCLUSIONS: No alteration was found in the gene expression between wild and polymorphic genotypes of IL-23R (rs2201841 and rs7530511) variations, indicating they do not contribute to altering the levels of gene expression in blood. In summary, our data show that the alleles of two SNPs in IL-23R rs2201841 and rs7530511 are associated with BP.",
keywords = "Aged, Female, Humans, Interleukin-17/blood, Male, Pemphigoid, Bullous/blood, Polymorphism, Single Nucleotide, Receptors, Interleukin/blood, Receptors, Interleukin-17/blood, Th17 Cells/metabolism",
author = "Pardis-Sadat Tabatabaei-Panah and Hamideh Moravvej and Sahel Aghaei and Maryam Akbari and Sakineh Rajabi and Atena Kia and Elaheh Ebrahimi and Zahra Sadaf and Alireza Atoon and Nasim Behravesh and Ludwig, {Ralf J} and Reza Akbarzadeh",
note = "{\textcopyright} 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.",
year = "2020",
month = dec,
doi = "10.1002/mgg3.1519",
language = "English",
volume = "8",
journal = "MOL GENET GENOM MED",
issn = "2324-9269",
publisher = "John Wiley and Sons Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - TH17/IL23 cytokine gene polymorphisms in bullous pemphigoid

AU - Tabatabaei-Panah, Pardis-Sadat

AU - Moravvej, Hamideh

AU - Aghaei, Sahel

AU - Akbari, Maryam

AU - Rajabi, Sakineh

AU - Kia, Atena

AU - Ebrahimi, Elaheh

AU - Sadaf, Zahra

AU - Atoon, Alireza

AU - Behravesh, Nasim

AU - Ludwig, Ralf J

AU - Akbarzadeh, Reza

N1 - © 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.

PY - 2020/12

Y1 - 2020/12

N2 - BACKGROUND: TH17/IL-23 immune axis is considered to be involved in the pathogenesis of autoimmune and chronic inflammatory diseases. Bullous pemphigoid (BP) is the most frequent autoimmune blistering disease, characterized by the presence of autoantibodies against the components of the dermal-epidermal junction. Animal studies and characterization of patient samples point toward a contribution of TH17 cells in BP pathogenesis. However, genetic polymorphisms in the genes of TH17/IL-23 cytokines have not yet been well investigated in BP.METHODS: Detection of polymorphisms in IL-17A (rs2275913 and rs3819025), IL-17F (rs2397084 and rs763780), IL-17RA (rs2229151), and IL-23R (rs2201841, rs7530511, rs11209026, and rs10889677) genes were performed following the collection of blood samples and DNA extraction from BP patients and controls. Gene expression of IL-23R was determined by quantitative RT-PCR analysis.RESULTS: The prevalence of IL-23R rs7530511 genotypes and alleles, as well as IL-23R rs2201841 alleles, is significantly different between the BP patients and controls. While the minor C-allele of IL-23R rs7530511 is highly present in the patients, the G-allele distribution of IL-23R rs2201841 is significantly more prevalent in the control individuals compared to the BP patients. Genotypes and alleles of other SNPs in IL-17A, IL-17F, and IL-17RA were similarly distributed in patients and controls.CONCLUSIONS: No alteration was found in the gene expression between wild and polymorphic genotypes of IL-23R (rs2201841 and rs7530511) variations, indicating they do not contribute to altering the levels of gene expression in blood. In summary, our data show that the alleles of two SNPs in IL-23R rs2201841 and rs7530511 are associated with BP.

AB - BACKGROUND: TH17/IL-23 immune axis is considered to be involved in the pathogenesis of autoimmune and chronic inflammatory diseases. Bullous pemphigoid (BP) is the most frequent autoimmune blistering disease, characterized by the presence of autoantibodies against the components of the dermal-epidermal junction. Animal studies and characterization of patient samples point toward a contribution of TH17 cells in BP pathogenesis. However, genetic polymorphisms in the genes of TH17/IL-23 cytokines have not yet been well investigated in BP.METHODS: Detection of polymorphisms in IL-17A (rs2275913 and rs3819025), IL-17F (rs2397084 and rs763780), IL-17RA (rs2229151), and IL-23R (rs2201841, rs7530511, rs11209026, and rs10889677) genes were performed following the collection of blood samples and DNA extraction from BP patients and controls. Gene expression of IL-23R was determined by quantitative RT-PCR analysis.RESULTS: The prevalence of IL-23R rs7530511 genotypes and alleles, as well as IL-23R rs2201841 alleles, is significantly different between the BP patients and controls. While the minor C-allele of IL-23R rs7530511 is highly present in the patients, the G-allele distribution of IL-23R rs2201841 is significantly more prevalent in the control individuals compared to the BP patients. Genotypes and alleles of other SNPs in IL-17A, IL-17F, and IL-17RA were similarly distributed in patients and controls.CONCLUSIONS: No alteration was found in the gene expression between wild and polymorphic genotypes of IL-23R (rs2201841 and rs7530511) variations, indicating they do not contribute to altering the levels of gene expression in blood. In summary, our data show that the alleles of two SNPs in IL-23R rs2201841 and rs7530511 are associated with BP.

KW - Aged

KW - Female

KW - Humans

KW - Interleukin-17/blood

KW - Male

KW - Pemphigoid, Bullous/blood

KW - Polymorphism, Single Nucleotide

KW - Receptors, Interleukin/blood

KW - Receptors, Interleukin-17/blood

KW - Th17 Cells/metabolism

U2 - 10.1002/mgg3.1519

DO - 10.1002/mgg3.1519

M3 - SCORING: Journal article

C2 - 33340282

VL - 8

JO - MOL GENET GENOM MED

JF - MOL GENET GENOM MED

SN - 2324-9269

IS - 12

M1 - e1519

ER -