Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
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Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. / Huber, Samuel; Gagliani, Nicola; Esplugues, Enric; O'Connor, William; Huber, Francis J; Chaudhry, Ashutosh; Kamanaka, Masahito; Kobayashi, Yasushi; Booth, Carmen J; Rudensky, Alexander Y; Roncarolo, Maria Grazia; Battaglia, Manuela; Flavell, Richard A.
in: IMMUNITY, Jahrgang 34, Nr. 4, 4, 22.04.2011, S. 554-565.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
AU - Huber, Samuel
AU - Gagliani, Nicola
AU - Esplugues, Enric
AU - O'Connor, William
AU - Huber, Francis J
AU - Chaudhry, Ashutosh
AU - Kamanaka, Masahito
AU - Kobayashi, Yasushi
AU - Booth, Carmen J
AU - Rudensky, Alexander Y
AU - Roncarolo, Maria Grazia
AU - Battaglia, Manuela
AU - Flavell, Richard A
N1 - Copyright © 2011 Elsevier Inc. All rights reserved.
PY - 2011/4/22
Y1 - 2011/4/22
N2 - T helper 17 (Th17) cells are important for host defense against extracellular microorganisms. However, they are also implicated in autoimmune and chronic inflammatory diseases, and as such need to be tightly regulated. The mechanisms that directly control committed pathogenic Th17 cells in vivo remain unclear. We showed here that IL-17A-producing CD4+ T cells expressed interleukin-10 receptor ? (IL-10R?) in vivo. Importantly, T cell-specific blockade of IL-10 signaling led to a selective increase of IL-17A+IFN-?? (Th17) and IL-17A+IFN-?+ (Th17+Th1) CD4+ T cells during intestinal inflammation in the small intestine. CD4+Foxp3? IL-10-producing (Tr1) cells and CD4+Foxp3+ regulatory (Treg) cells were able to control Th17 and Th17+Th1 cells in an IL-10-dependent manner in vivo. Lastly, IL-10 treatment of mice with established colitis decreased Th17 and Th17+Th1 cell frequencies via direct signaling in T cells. Thus, IL-10 signaling directly suppresses Th17 and Th17+Th1 cells.
AB - T helper 17 (Th17) cells are important for host defense against extracellular microorganisms. However, they are also implicated in autoimmune and chronic inflammatory diseases, and as such need to be tightly regulated. The mechanisms that directly control committed pathogenic Th17 cells in vivo remain unclear. We showed here that IL-17A-producing CD4+ T cells expressed interleukin-10 receptor ? (IL-10R?) in vivo. Importantly, T cell-specific blockade of IL-10 signaling led to a selective increase of IL-17A+IFN-?? (Th17) and IL-17A+IFN-?+ (Th17+Th1) CD4+ T cells during intestinal inflammation in the small intestine. CD4+Foxp3? IL-10-producing (Tr1) cells and CD4+Foxp3+ regulatory (Treg) cells were able to control Th17 and Th17+Th1 cells in an IL-10-dependent manner in vivo. Lastly, IL-10 treatment of mice with established colitis decreased Th17 and Th17+Th1 cell frequencies via direct signaling in T cells. Thus, IL-10 signaling directly suppresses Th17 and Th17+Th1 cells.
KW - Animals
KW - Disease Progression
KW - Mice
KW - Mice, Inbred C57BL
KW - Signal Transduction
KW - Cell Proliferation
KW - Interferon-gamma/immunology
KW - CD4-Positive T-Lymphocytes/cytology/immunology/metabolism
KW - Colitis/immunology/pathology
KW - Forkhead Transcription Factors/immunology
KW - Interleukin-10/immunology/metabolism
KW - Interleukin-10 Receptor alpha Subunit/immunology/metabolism
KW - Peptide Fragments/immunology
KW - Th17 Cells/cytology/immunology/metabolism
KW - Animals
KW - Disease Progression
KW - Mice
KW - Mice, Inbred C57BL
KW - Signal Transduction
KW - Cell Proliferation
KW - Interferon-gamma/immunology
KW - CD4-Positive T-Lymphocytes/cytology/immunology/metabolism
KW - Colitis/immunology/pathology
KW - Forkhead Transcription Factors/immunology
KW - Interleukin-10/immunology/metabolism
KW - Interleukin-10 Receptor alpha Subunit/immunology/metabolism
KW - Peptide Fragments/immunology
KW - Th17 Cells/cytology/immunology/metabolism
U2 - 10.1016/j.immuni.2011.01.020
DO - 10.1016/j.immuni.2011.01.020
M3 - SCORING: Journal article
C2 - 21511184
VL - 34
SP - 554
EP - 565
JO - IMMUNITY
JF - IMMUNITY
SN - 1074-7613
IS - 4
M1 - 4
ER -