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Temporal pattern of cytotoxic edema in the perihematomal region after intracerebral hemorrhage: a serial magnetic resonance imaging study

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Temporal pattern of cytotoxic edema in the perihematomal region after intracerebral hemorrhage: a serial magnetic resonance imaging study. / Li, Na; Worthmann, Hans; Heeren, Meike; Schuppner, Ramona; Deb-Chatterji, Milani; Tryc, Anita B; Bueltmann, Eva; Lanfermann, Heinrich; Donnerstag, Frank; Weissenborn, Karin; Raab, Peter.

in: STROKE, Jahrgang 44, Nr. 4, 04.2013, S. 1144-6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Li, N, Worthmann, H, Heeren, M, Schuppner, R, Deb-Chatterji, M, Tryc, AB, Bueltmann, E, Lanfermann, H, Donnerstag, F, Weissenborn, K & Raab, P 2013, 'Temporal pattern of cytotoxic edema in the perihematomal region after intracerebral hemorrhage: a serial magnetic resonance imaging study', STROKE, Jg. 44, Nr. 4, S. 1144-6. https://doi.org/10.1161/STROKEAHA.111.000056

APA

Li, N., Worthmann, H., Heeren, M., Schuppner, R., Deb-Chatterji, M., Tryc, A. B., Bueltmann, E., Lanfermann, H., Donnerstag, F., Weissenborn, K., & Raab, P. (2013). Temporal pattern of cytotoxic edema in the perihematomal region after intracerebral hemorrhage: a serial magnetic resonance imaging study. STROKE, 44(4), 1144-6. https://doi.org/10.1161/STROKEAHA.111.000056

Vancouver

Li N, Worthmann H, Heeren M, Schuppner R, Deb-Chatterji M, Tryc AB et al. Temporal pattern of cytotoxic edema in the perihematomal region after intracerebral hemorrhage: a serial magnetic resonance imaging study. STROKE. 2013 Apr;44(4):1144-6. https://doi.org/10.1161/STROKEAHA.111.000056

Bibtex

@article{e10bc7c7eab545bfbb3f65e28f0e3765,
title = "Temporal pattern of cytotoxic edema in the perihematomal region after intracerebral hemorrhage: a serial magnetic resonance imaging study",
abstract = "BACKGROUND AND PURPOSE: Knowledge about cytotoxic edema (CE) in intracerebral hemorrhage is still limited. We aimed to analyze its presence, temporal pattern, and prognostic meaning.METHODS: Twenty-one patients with primary intracerebral hemorrhage underwent magnetic resonance imaging at days 1, 3, and 7 after symptom onset. CE was identified using diffusion-weighted imaging. Hematoma and perihematomal edema volumes were measured on fluid-attenuated inversion recovery images. National Institutes of Health Stroke Scale score was assessed at admission and with each magnetic resonance imaging. Clinical outcome was assessed by modified Rankin scale at 90 days.RESULTS: CE appeared in half of the patients within the first 24 hours. The apparent diffusion coefficient values decreased until day 3 and were significantly reversed from days 3 through 7 (P<0.01). Patients with CE showed significantly faster perihematomal edema growth from day 0 to 1 (P=0.036) than those without. Larger 3-day perihematomal edema volume (P=0.02) and presence of CE on day 3 (P=0.07) were associated with poor clinical outcome.CONCLUSIONS: CE is associated with stroke severity, perihematomal edema volume, and poor outcome. It is considered to indicate ongoing neuronal injury and, thus, might emerge as new treatment target.",
keywords = "Brain, Brain Edema, Cerebral Hemorrhage, Diffusion Magnetic Resonance Imaging, Hematoma, Humans, Magnetic Resonance Imaging, Neurons, Prognosis, Risk, Stroke, Time Factors, Treatment Outcome, Journal Article",
author = "Na Li and Hans Worthmann and Meike Heeren and Ramona Schuppner and Milani Deb-Chatterji and Tryc, {Anita B} and Eva Bueltmann and Heinrich Lanfermann and Frank Donnerstag and Karin Weissenborn and Peter Raab",
year = "2013",
month = apr,
doi = "10.1161/STROKEAHA.111.000056",
language = "English",
volume = "44",
pages = "1144--6",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Temporal pattern of cytotoxic edema in the perihematomal region after intracerebral hemorrhage: a serial magnetic resonance imaging study

AU - Li, Na

AU - Worthmann, Hans

AU - Heeren, Meike

AU - Schuppner, Ramona

AU - Deb-Chatterji, Milani

AU - Tryc, Anita B

AU - Bueltmann, Eva

AU - Lanfermann, Heinrich

AU - Donnerstag, Frank

AU - Weissenborn, Karin

AU - Raab, Peter

PY - 2013/4

Y1 - 2013/4

N2 - BACKGROUND AND PURPOSE: Knowledge about cytotoxic edema (CE) in intracerebral hemorrhage is still limited. We aimed to analyze its presence, temporal pattern, and prognostic meaning.METHODS: Twenty-one patients with primary intracerebral hemorrhage underwent magnetic resonance imaging at days 1, 3, and 7 after symptom onset. CE was identified using diffusion-weighted imaging. Hematoma and perihematomal edema volumes were measured on fluid-attenuated inversion recovery images. National Institutes of Health Stroke Scale score was assessed at admission and with each magnetic resonance imaging. Clinical outcome was assessed by modified Rankin scale at 90 days.RESULTS: CE appeared in half of the patients within the first 24 hours. The apparent diffusion coefficient values decreased until day 3 and were significantly reversed from days 3 through 7 (P<0.01). Patients with CE showed significantly faster perihematomal edema growth from day 0 to 1 (P=0.036) than those without. Larger 3-day perihematomal edema volume (P=0.02) and presence of CE on day 3 (P=0.07) were associated with poor clinical outcome.CONCLUSIONS: CE is associated with stroke severity, perihematomal edema volume, and poor outcome. It is considered to indicate ongoing neuronal injury and, thus, might emerge as new treatment target.

AB - BACKGROUND AND PURPOSE: Knowledge about cytotoxic edema (CE) in intracerebral hemorrhage is still limited. We aimed to analyze its presence, temporal pattern, and prognostic meaning.METHODS: Twenty-one patients with primary intracerebral hemorrhage underwent magnetic resonance imaging at days 1, 3, and 7 after symptom onset. CE was identified using diffusion-weighted imaging. Hematoma and perihematomal edema volumes were measured on fluid-attenuated inversion recovery images. National Institutes of Health Stroke Scale score was assessed at admission and with each magnetic resonance imaging. Clinical outcome was assessed by modified Rankin scale at 90 days.RESULTS: CE appeared in half of the patients within the first 24 hours. The apparent diffusion coefficient values decreased until day 3 and were significantly reversed from days 3 through 7 (P<0.01). Patients with CE showed significantly faster perihematomal edema growth from day 0 to 1 (P=0.036) than those without. Larger 3-day perihematomal edema volume (P=0.02) and presence of CE on day 3 (P=0.07) were associated with poor clinical outcome.CONCLUSIONS: CE is associated with stroke severity, perihematomal edema volume, and poor outcome. It is considered to indicate ongoing neuronal injury and, thus, might emerge as new treatment target.

KW - Brain

KW - Brain Edema

KW - Cerebral Hemorrhage

KW - Diffusion Magnetic Resonance Imaging

KW - Hematoma

KW - Humans

KW - Magnetic Resonance Imaging

KW - Neurons

KW - Prognosis

KW - Risk

KW - Stroke

KW - Time Factors

KW - Treatment Outcome

KW - Journal Article

U2 - 10.1161/STROKEAHA.111.000056

DO - 10.1161/STROKEAHA.111.000056

M3 - SCORING: Journal article

C2 - 23391767

VL - 44

SP - 1144

EP - 1146

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 4

ER -