Telomerase activity of Merkel cell carcinomas and Merkel cell carcinoma-derived cell cultures.

Standard

Telomerase activity of Merkel cell carcinomas and Merkel cell carcinoma-derived cell cultures. / Stöppler, H; Stöppler, M C; Kisiela, M; Holzbach, A; Moll, Ingrid; Houdek, P; Moll, R.

in: ARCH DERMATOL RES, Jahrgang 293, Nr. 8, 8, 2001, S. 397-406.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

Harvard

Stöppler, H, Stöppler, MC, Kisiela, M, Holzbach, A, Moll, I, Houdek, P & Moll, R 2001, 'Telomerase activity of Merkel cell carcinomas and Merkel cell carcinoma-derived cell cultures.', ARCH DERMATOL RES, Jg. 293, Nr. 8, 8, S. 397-406. <http://www.ncbi.nlm.nih.gov/pubmed/11686515?dopt=Citation>

APA

Stöppler, H., Stöppler, M. C., Kisiela, M., Holzbach, A., Moll, I., Houdek, P., & Moll, R. (2001). Telomerase activity of Merkel cell carcinomas and Merkel cell carcinoma-derived cell cultures. ARCH DERMATOL RES, 293(8), 397-406. [8]. http://www.ncbi.nlm.nih.gov/pubmed/11686515?dopt=Citation

Vancouver

Stöppler H, Stöppler MC, Kisiela M, Holzbach A, Moll I, Houdek P et al. Telomerase activity of Merkel cell carcinomas and Merkel cell carcinoma-derived cell cultures. ARCH DERMATOL RES. 2001;293(8):397-406. 8.

Bibtex

@article{81e55ba215544f7f808fa4992631ed1a,
title = "Telomerase activity of Merkel cell carcinomas and Merkel cell carcinoma-derived cell cultures.",
abstract = "Merkel cell carcinomas are rare malignant tumors of the skin, which are predominantly observed in elderly patients (mean age 65-70 years). It is believed but not yet proven that these tumors are derived from the Merkel cells of the epidermis and hair follicles. The Merkel cells themselves probably originate from an asymmetric cell division of basal keratinocytes and the resulting differentiated Merkel cells have presumably, at least in humans, lost their growth potential. The capability of indefinite cell division in germ line cells and in the great majority of malignant tumors as well as an increased growth potential in certain somatic cells (such as basal cells of renewable tissues) is correlated with cellular telomerase activity, which is absent in differentiated somatic cells. In this study the telomerase activity in cryostat sections of frozen Merkel cell tumor biopsies and in in vitro cultivated Merkel cell carcinoma cells was analyzed. We detected telomerase activity in four tumors and three of four cell cultures. These results show that despite their pronounced neuroendocrine differentiation and their occurrence in patients of advanced age, Merkel cell carcinomas possess telomerase activity similar to that of common carcinoma types.",
author = "H St{\"o}ppler and St{\"o}ppler, {M C} and M Kisiela and A Holzbach and Ingrid Moll and P Houdek and R Moll",
year = "2001",
language = "Deutsch",
volume = "293",
pages = "397--406",
journal = "ARCH DERMATOL RES",
issn = "0340-3696",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Telomerase activity of Merkel cell carcinomas and Merkel cell carcinoma-derived cell cultures.

AU - Stöppler, H

AU - Stöppler, M C

AU - Kisiela, M

AU - Holzbach, A

AU - Moll, Ingrid

AU - Houdek, P

AU - Moll, R

PY - 2001

Y1 - 2001

N2 - Merkel cell carcinomas are rare malignant tumors of the skin, which are predominantly observed in elderly patients (mean age 65-70 years). It is believed but not yet proven that these tumors are derived from the Merkel cells of the epidermis and hair follicles. The Merkel cells themselves probably originate from an asymmetric cell division of basal keratinocytes and the resulting differentiated Merkel cells have presumably, at least in humans, lost their growth potential. The capability of indefinite cell division in germ line cells and in the great majority of malignant tumors as well as an increased growth potential in certain somatic cells (such as basal cells of renewable tissues) is correlated with cellular telomerase activity, which is absent in differentiated somatic cells. In this study the telomerase activity in cryostat sections of frozen Merkel cell tumor biopsies and in in vitro cultivated Merkel cell carcinoma cells was analyzed. We detected telomerase activity in four tumors and three of four cell cultures. These results show that despite their pronounced neuroendocrine differentiation and their occurrence in patients of advanced age, Merkel cell carcinomas possess telomerase activity similar to that of common carcinoma types.

AB - Merkel cell carcinomas are rare malignant tumors of the skin, which are predominantly observed in elderly patients (mean age 65-70 years). It is believed but not yet proven that these tumors are derived from the Merkel cells of the epidermis and hair follicles. The Merkel cells themselves probably originate from an asymmetric cell division of basal keratinocytes and the resulting differentiated Merkel cells have presumably, at least in humans, lost their growth potential. The capability of indefinite cell division in germ line cells and in the great majority of malignant tumors as well as an increased growth potential in certain somatic cells (such as basal cells of renewable tissues) is correlated with cellular telomerase activity, which is absent in differentiated somatic cells. In this study the telomerase activity in cryostat sections of frozen Merkel cell tumor biopsies and in in vitro cultivated Merkel cell carcinoma cells was analyzed. We detected telomerase activity in four tumors and three of four cell cultures. These results show that despite their pronounced neuroendocrine differentiation and their occurrence in patients of advanced age, Merkel cell carcinomas possess telomerase activity similar to that of common carcinoma types.

M3 - SCORING: Zeitschriftenaufsatz

VL - 293

SP - 397

EP - 406

JO - ARCH DERMATOL RES

JF - ARCH DERMATOL RES

SN - 0340-3696

IS - 8

M1 - 8

ER -