T-cell epitopes of PLA2R1 in membranous nephropathy
Beteiligte Einrichtungen
Abstract
The discovery of phospholipase A2 receptor 1 as the major target antigen in membranous nephropathy (MN) has initiated a decade of major advances in the understanding of MN pathophysiology and improvement of patient care. In this Issue, Zhang et al. identified potential T-cell epitopes of phospholipase A2 receptor 1 in patients with MN. The characterization of the pathogenic T- and B-cell epitopes on phospholipase A2 receptor 1 is an important step moving from the current unspecific immunosuppressive therapies toward antigen-specific MN treatments.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 0085-2538 |
DOIs |
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Status | Veröffentlicht - 03.2023 |
Anmerkungen des Dekanats
Copyright © 2023 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
PubMed | 36822752 |
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