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Tau's role in the developing brain: implications for intellectual disability.

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Tau's role in the developing brain: implications for intellectual disability. / Sapir, Tamar; Frotscher, Michael; Levy, Talia; Mandelkow, Eva-Maria; Reiner, Orly.

in: HUM MOL GENET, Jahrgang 21, Nr. 8, 8, 2012, S. 1681-1692.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sapir, T, Frotscher, M, Levy, T, Mandelkow, E-M & Reiner, O 2012, 'Tau's role in the developing brain: implications for intellectual disability.', HUM MOL GENET, Jg. 21, Nr. 8, 8, S. 1681-1692. <http://www.ncbi.nlm.nih.gov/pubmed/22194194?dopt=Citation>

APA

Sapir, T., Frotscher, M., Levy, T., Mandelkow, E-M., & Reiner, O. (2012). Tau's role in the developing brain: implications for intellectual disability. HUM MOL GENET, 21(8), 1681-1692. [8]. http://www.ncbi.nlm.nih.gov/pubmed/22194194?dopt=Citation

Vancouver

Sapir T, Frotscher M, Levy T, Mandelkow E-M, Reiner O. Tau's role in the developing brain: implications for intellectual disability. HUM MOL GENET. 2012;21(8):1681-1692. 8.

Bibtex

@article{886d136a278442fbaf7a192c218b9b0e,
title = "Tau's role in the developing brain: implications for intellectual disability.",
abstract = "Microdeletions encompassing the MAPT (Tau) locus resulting in intellectual disability raised the hypothesis that Tau may regulate early functions in the developing brain. Our results indicate that neuronal migration was inhibited in mouse brains following Tau reduction. In addition, the leading edge of radially migrating neurons was aberrant in spite of normal morphology of radial glia. Furthermore, intracellular mitochondrial transport and morphology were affected. In early postnatal brains, a portion of Tau knocked down neurons reached the cortical plate. Nevertheless, they exhibited far less developed dendrites and a striking reduction in connectivity evident by the size of boutons. Our novel results strongly implicate MAPT as a dosage-sensitive gene in this locus involved in intellectual disability. Furthermore, our results are likely to impact our understanding of other diseases involving Tau.",
author = "Tamar Sapir and Michael Frotscher and Talia Levy and Eva-Maria Mandelkow and Orly Reiner",
year = "2012",
language = "English",
volume = "21",
pages = "1681--1692",
journal = "HUM MOL GENET",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Tau's role in the developing brain: implications for intellectual disability.

AU - Sapir, Tamar

AU - Frotscher, Michael

AU - Levy, Talia

AU - Mandelkow, Eva-Maria

AU - Reiner, Orly

PY - 2012

Y1 - 2012

N2 - Microdeletions encompassing the MAPT (Tau) locus resulting in intellectual disability raised the hypothesis that Tau may regulate early functions in the developing brain. Our results indicate that neuronal migration was inhibited in mouse brains following Tau reduction. In addition, the leading edge of radially migrating neurons was aberrant in spite of normal morphology of radial glia. Furthermore, intracellular mitochondrial transport and morphology were affected. In early postnatal brains, a portion of Tau knocked down neurons reached the cortical plate. Nevertheless, they exhibited far less developed dendrites and a striking reduction in connectivity evident by the size of boutons. Our novel results strongly implicate MAPT as a dosage-sensitive gene in this locus involved in intellectual disability. Furthermore, our results are likely to impact our understanding of other diseases involving Tau.

AB - Microdeletions encompassing the MAPT (Tau) locus resulting in intellectual disability raised the hypothesis that Tau may regulate early functions in the developing brain. Our results indicate that neuronal migration was inhibited in mouse brains following Tau reduction. In addition, the leading edge of radially migrating neurons was aberrant in spite of normal morphology of radial glia. Furthermore, intracellular mitochondrial transport and morphology were affected. In early postnatal brains, a portion of Tau knocked down neurons reached the cortical plate. Nevertheless, they exhibited far less developed dendrites and a striking reduction in connectivity evident by the size of boutons. Our novel results strongly implicate MAPT as a dosage-sensitive gene in this locus involved in intellectual disability. Furthermore, our results are likely to impact our understanding of other diseases involving Tau.

M3 - SCORING: Journal article

VL - 21

SP - 1681

EP - 1692

JO - HUM MOL GENET

JF - HUM MOL GENET

SN - 0964-6906

IS - 8

M1 - 8

ER -