Targeting migraine treatment with neuroimaging-Pharmacological neuroimaging in headaches

TY - JOUR

T1 - Targeting migraine treatment with neuroimaging-Pharmacological neuroimaging in headaches

AU - Peng, Kuan-Po

AU - May, Arne

N1 - © 2020 Elsevier B.V. All rights reserved.

PY - 2020

Y1 - 2020

N2 - PURPOSE: The current review provides a recapitulation of recent advances in pharmacological neuroimaging in headache, a promising tool to understanding of how a drug works in the brain and how it may lead to new insights of disease mechanisms of headache.RESULTS: Pharmacological positron emission tomography with radioligand-labeled medication may provide evidence whether and where a medication binds in the brain but is still mostly restricted to animal work. Pharmacological functional MRI using task-specific approaches identified central modulation patterns as a consequence of attack and preventative headache medication, which may be distinct to a specific drug mechanism. Pharmacological neuroimaging and specifically in combination with functional imaging is a promising tool to better understand not only certain medications but also certain disease mechanisms.SUMMARY: Pharmacological imaging techniques have advanced over the last few years and showed great potential of providing new insights into drug pharmacodynamics and disease mechanism. There are still limitations and challenges to be overcome.

AB - PURPOSE: The current review provides a recapitulation of recent advances in pharmacological neuroimaging in headache, a promising tool to understanding of how a drug works in the brain and how it may lead to new insights of disease mechanisms of headache.RESULTS: Pharmacological positron emission tomography with radioligand-labeled medication may provide evidence whether and where a medication binds in the brain but is still mostly restricted to animal work. Pharmacological functional MRI using task-specific approaches identified central modulation patterns as a consequence of attack and preventative headache medication, which may be distinct to a specific drug mechanism. Pharmacological neuroimaging and specifically in combination with functional imaging is a promising tool to better understand not only certain medications but also certain disease mechanisms.SUMMARY: Pharmacological imaging techniques have advanced over the last few years and showed great potential of providing new insights into drug pharmacodynamics and disease mechanism. There are still limitations and challenges to be overcome.

U2 - 10.1016/bs.pbr.2020.05.011

DO - 10.1016/bs.pbr.2020.05.011

M3 - SCORING: Review article

C2 - 33008512

VL - 255

SP - 327

EP - 342

JO - PROG BRAIN RES

JF - PROG BRAIN RES

SN - 0079-6123

ER -