Tapioca melanomas of the iris
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Tapioca melanomas of the iris : immunohistology and report on two cases. / Hassenstein, A; Bialasiewicz, A A; von Domarus, D; Schäfer, H; Richard, G.
in: GRAEF ARCH CLIN EXP, Jahrgang 237, Nr. 5, 01.05.1999, S. 424-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Tapioca melanomas of the iris
T2 - immunohistology and report on two cases
AU - Hassenstein, A
AU - Bialasiewicz, A A
AU - von Domarus, D
AU - Schäfer, H
AU - Richard, G
PY - 1999/5/1
Y1 - 1999/5/1
N2 - BACKGROUND: Tapioca-like tumors are rare, and their benign or malignant nature is obscure without histological work-up. We report on the clinical and histological features of different types of tumors in two patients.CASE REPORT: Two patients aged 17 and 45 years presented with brownish iris masses increasing in size. Full-thickness en bloc excision of melanocytic tumors (5.5 mm and 7.0 mm in diameter) was carried out. Histological work-up revealed a nevus cell nevus in the young patient and an epithelioid malignant melanoma in the middle-aged patient evolving from the ciliary body. Staining for HMB-45 was marked in both tumors, for S-100 low in the nevus and marked in the melanoma, and for p53 negative in the nevus and positive in the melanoma. Ki67 stains were negative.CONCLUSION: We propose that excision of anteriorly located pigmented tumors that increase in size is indicated in order to determine whether they are benign or malignant. In these case reports, tapioca-like tumors include a benign and a malignant entity. To our knowledge, a nevus cell nevus presenting as a tapioca-like tumor has not previously been described. Curative surgery and histological and immunohistological evaluation are required to characterize the malignant potential of these tumors and the prognosis.
AB - BACKGROUND: Tapioca-like tumors are rare, and their benign or malignant nature is obscure without histological work-up. We report on the clinical and histological features of different types of tumors in two patients.CASE REPORT: Two patients aged 17 and 45 years presented with brownish iris masses increasing in size. Full-thickness en bloc excision of melanocytic tumors (5.5 mm and 7.0 mm in diameter) was carried out. Histological work-up revealed a nevus cell nevus in the young patient and an epithelioid malignant melanoma in the middle-aged patient evolving from the ciliary body. Staining for HMB-45 was marked in both tumors, for S-100 low in the nevus and marked in the melanoma, and for p53 negative in the nevus and positive in the melanoma. Ki67 stains were negative.CONCLUSION: We propose that excision of anteriorly located pigmented tumors that increase in size is indicated in order to determine whether they are benign or malignant. In these case reports, tapioca-like tumors include a benign and a malignant entity. To our knowledge, a nevus cell nevus presenting as a tapioca-like tumor has not previously been described. Curative surgery and histological and immunohistological evaluation are required to characterize the malignant potential of these tumors and the prognosis.
KW - Adolescent
KW - Antigens, Neoplasm
KW - Female
KW - Humans
KW - Immunoenzyme Techniques
KW - Iris Neoplasms
KW - Ki-67 Antigen
KW - Melanoma
KW - Melanoma-Specific Antigens
KW - Middle Aged
KW - Neoplasm Proteins
KW - S100 Proteins
KW - Tumor Markers, Biological
KW - Tumor Suppressor Protein p53
M3 - SCORING: Journal article
C2 - 10333110
VL - 237
SP - 424
EP - 428
JO - GRAEF ARCH CLIN EXP
JF - GRAEF ARCH CLIN EXP
SN - 0721-832X
IS - 5
ER -