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Tandem exploitation of Helix pomatia glycosyltransferases: facile syntheses of H-antigen-bearing oligosaccharides.

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Tandem exploitation of Helix pomatia glycosyltransferases: facile syntheses of H-antigen-bearing oligosaccharides. / Bretting, Hagen; Buck, Friedrich; Jacobs, Günter; Meinke, Sebastian; Scheppokat, Angela M; Thiem, Joachim.

in: CHEM-EUR J, Jahrgang 13, Nr. 25, 25, 2007, S. 7144-7152.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bretting, H, Buck, F, Jacobs, G, Meinke, S, Scheppokat, AM & Thiem, J 2007, 'Tandem exploitation of Helix pomatia glycosyltransferases: facile syntheses of H-antigen-bearing oligosaccharides.', CHEM-EUR J, Jg. 13, Nr. 25, 25, S. 7144-7152. <http://www.ncbi.nlm.nih.gov/pubmed/17591726?dopt=Citation>

APA

Bretting, H., Buck, F., Jacobs, G., Meinke, S., Scheppokat, A. M., & Thiem, J. (2007). Tandem exploitation of Helix pomatia glycosyltransferases: facile syntheses of H-antigen-bearing oligosaccharides. CHEM-EUR J, 13(25), 7144-7152. [25]. http://www.ncbi.nlm.nih.gov/pubmed/17591726?dopt=Citation

Vancouver

Bretting H, Buck F, Jacobs G, Meinke S, Scheppokat AM, Thiem J. Tandem exploitation of Helix pomatia glycosyltransferases: facile syntheses of H-antigen-bearing oligosaccharides. CHEM-EUR J. 2007;13(25):7144-7152. 25.

Bibtex

@article{140a7c2436c54b10b899465761ef1a75,
title = "Tandem exploitation of Helix pomatia glycosyltransferases: facile syntheses of H-antigen-bearing oligosaccharides.",
abstract = "Snails from the family Helicidae produce in their albumen glands a highly branched galactan, which consists almost exclusively of D- and L-galactose. The D-Gal residues are glycosydically beta(1-->6)- or beta(1-->3)-linked, whereas the L-Gal moieties are attached alpha(1-->2). Up until the present time, two beta(1-->6)-D-galactosyl transferases and one alpha(1-->2)-L-galactosyl transferase have been identified in a membrane preparation of these glands. These were used to synthesise various oligosaccharides by successive addition of the NDP-activated (NDP=nucleoside-5'-diphosphate) D-Gal or L-Fuc moieties, up to a heptasaccharide by starting from the disaccharide D-Gal-beta(1-->3)-D-Gal-beta(1-->OMe. Even larger oligosaccharides up to a tridecasaccharide were obtained by starting with the hexasaccharide D-Gal-[beta(1-->3)-D-Gal]4-beta(1-->4)-D-Glc as an acceptor substrate. This tandem exploitation process has high potential for the easy introduction of D-Gal and L-Fuc residues into a great variety of oligosaccharides, which can be used in ligand/acceptor studies.",
author = "Hagen Bretting and Friedrich Buck and G{\"u}nter Jacobs and Sebastian Meinke and Scheppokat, {Angela M} and Joachim Thiem",
year = "2007",
language = "Deutsch",
volume = "13",
pages = "7144--7152",
journal = "CHEM-EUR J",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag GmbH",
number = "25",

}

RIS

TY - JOUR

T1 - Tandem exploitation of Helix pomatia glycosyltransferases: facile syntheses of H-antigen-bearing oligosaccharides.

AU - Bretting, Hagen

AU - Buck, Friedrich

AU - Jacobs, Günter

AU - Meinke, Sebastian

AU - Scheppokat, Angela M

AU - Thiem, Joachim

PY - 2007

Y1 - 2007

N2 - Snails from the family Helicidae produce in their albumen glands a highly branched galactan, which consists almost exclusively of D- and L-galactose. The D-Gal residues are glycosydically beta(1-->6)- or beta(1-->3)-linked, whereas the L-Gal moieties are attached alpha(1-->2). Up until the present time, two beta(1-->6)-D-galactosyl transferases and one alpha(1-->2)-L-galactosyl transferase have been identified in a membrane preparation of these glands. These were used to synthesise various oligosaccharides by successive addition of the NDP-activated (NDP=nucleoside-5'-diphosphate) D-Gal or L-Fuc moieties, up to a heptasaccharide by starting from the disaccharide D-Gal-beta(1-->3)-D-Gal-beta(1-->OMe. Even larger oligosaccharides up to a tridecasaccharide were obtained by starting with the hexasaccharide D-Gal-[beta(1-->3)-D-Gal]4-beta(1-->4)-D-Glc as an acceptor substrate. This tandem exploitation process has high potential for the easy introduction of D-Gal and L-Fuc residues into a great variety of oligosaccharides, which can be used in ligand/acceptor studies.

AB - Snails from the family Helicidae produce in their albumen glands a highly branched galactan, which consists almost exclusively of D- and L-galactose. The D-Gal residues are glycosydically beta(1-->6)- or beta(1-->3)-linked, whereas the L-Gal moieties are attached alpha(1-->2). Up until the present time, two beta(1-->6)-D-galactosyl transferases and one alpha(1-->2)-L-galactosyl transferase have been identified in a membrane preparation of these glands. These were used to synthesise various oligosaccharides by successive addition of the NDP-activated (NDP=nucleoside-5'-diphosphate) D-Gal or L-Fuc moieties, up to a heptasaccharide by starting from the disaccharide D-Gal-beta(1-->3)-D-Gal-beta(1-->OMe. Even larger oligosaccharides up to a tridecasaccharide were obtained by starting with the hexasaccharide D-Gal-[beta(1-->3)-D-Gal]4-beta(1-->4)-D-Glc as an acceptor substrate. This tandem exploitation process has high potential for the easy introduction of D-Gal and L-Fuc residues into a great variety of oligosaccharides, which can be used in ligand/acceptor studies.

M3 - SCORING: Zeitschriftenaufsatz

VL - 13

SP - 7144

EP - 7152

JO - CHEM-EUR J

JF - CHEM-EUR J

SN - 0947-6539

IS - 25

M1 - 25

ER -