Talking to the neighbours: The molecular and physiological mechanisms of clustered synaptic plasticity
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Talking to the neighbours: The molecular and physiological mechanisms of clustered synaptic plasticity. / van Bommel, Bas; Mikhaylova, Marina.
in: NEUROSCI BIOBEHAV R, Jahrgang 71, 12.2016, S. 352-361.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Talking to the neighbours: The molecular and physiological mechanisms of clustered synaptic plasticity
AU - van Bommel, Bas
AU - Mikhaylova, Marina
PY - 2016/12
Y1 - 2016/12
N2 - Synaptic connectivity forms the basis for neuronal communication and the storage of information. Experiences and learning of new abilities can drive remodelling of this connectivity and promotes the formation of spine clusters; dendritic segments with a higher spine density. Spines located within these segments are frequently co-activated, undergo different dynamics than synapses located outside of this dendritic compartment and have, in general, a longer lifetime. Several lines of evidence have shown that chemical synapses located close to each other share or compete for intracellular signalling molecules and structural resources. This sharing and competition directly influences spine dynamics. Spines can grow, shrink, increase or decrease the surface expression of receptors, channels and adhesion molecules or remain stable and unchanged over extended periods of time. Here we summarize recent discoveries and provide a closer look at spine clustering, dendritic segment-specific signalling and potential molecular mechanisms underlying associative and heterosynaptic plasticity.
AB - Synaptic connectivity forms the basis for neuronal communication and the storage of information. Experiences and learning of new abilities can drive remodelling of this connectivity and promotes the formation of spine clusters; dendritic segments with a higher spine density. Spines located within these segments are frequently co-activated, undergo different dynamics than synapses located outside of this dendritic compartment and have, in general, a longer lifetime. Several lines of evidence have shown that chemical synapses located close to each other share or compete for intracellular signalling molecules and structural resources. This sharing and competition directly influences spine dynamics. Spines can grow, shrink, increase or decrease the surface expression of receptors, channels and adhesion molecules or remain stable and unchanged over extended periods of time. Here we summarize recent discoveries and provide a closer look at spine clustering, dendritic segment-specific signalling and potential molecular mechanisms underlying associative and heterosynaptic plasticity.
U2 - DOI: 10.1016/j.neubiorev.2016.09.016
DO - DOI: 10.1016/j.neubiorev.2016.09.016
M3 - SCORING: Journal article
C2 - 27659124
VL - 71
SP - 352
EP - 361
JO - NEUROSCI BIOBEHAV R
JF - NEUROSCI BIOBEHAV R
SN - 0149-7634
ER -