T lymphocytes as targets of gene transfer with Moloney-type retroviral vectors.
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T lymphocytes as targets of gene transfer with Moloney-type retroviral vectors. / Ayuketang Ayuk, Francis; Zander, A R; Fehse, B.
in: CURR GENE THER, Jahrgang 1, Nr. 4, 4, 2001, S. 325-337.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - T lymphocytes as targets of gene transfer with Moloney-type retroviral vectors.
AU - Ayuketang Ayuk, Francis
AU - Zander, A R
AU - Fehse, B
PY - 2001
Y1 - 2001
N2 - Peripheral T lymphocytes are a target of choice for many gene therapeutic strategies. Retrovirus-mediated transduction allows genomic integration and long-term expression of transgenes in target cells. Over many years, low transduction efficiency into primary T lymphocytes has limited clinical application of existing protocols. Recently, gene transfer rates > 50% have been achieved facilitating clinical studies. More attention is thus being focused on the ability of gene-modified cells to carry out innate as well as conferred functions in vivo and the influence of culture conditions, retroviral vector and host response thereon.
AB - Peripheral T lymphocytes are a target of choice for many gene therapeutic strategies. Retrovirus-mediated transduction allows genomic integration and long-term expression of transgenes in target cells. Over many years, low transduction efficiency into primary T lymphocytes has limited clinical application of existing protocols. Recently, gene transfer rates > 50% have been achieved facilitating clinical studies. More attention is thus being focused on the ability of gene-modified cells to carry out innate as well as conferred functions in vivo and the influence of culture conditions, retroviral vector and host response thereon.
M3 - SCORING: Zeitschriftenaufsatz
VL - 1
SP - 325
EP - 337
IS - 4
M1 - 4
ER -
