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Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo

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Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo. / Wiemann, Katrin; Mittrücker, Hans-Willi; Feger, Ute; Welte, Stefan A; Yokoyama, Wayne M; Spies, Thomas; Rammensee, Hans-Georg; Steinle, Alexander.

in: J IMMUNOL, Jahrgang 175, Nr. 2, 15.07.2005, S. 720-9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wiemann, K, Mittrücker, H-W, Feger, U, Welte, SA, Yokoyama, WM, Spies, T, Rammensee, H-G & Steinle, A 2005, 'Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo', J IMMUNOL, Jg. 175, Nr. 2, S. 720-9.

APA

Wiemann, K., Mittrücker, H-W., Feger, U., Welte, S. A., Yokoyama, W. M., Spies, T., Rammensee, H-G., & Steinle, A. (2005). Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo. J IMMUNOL, 175(2), 720-9.

Vancouver

Wiemann K, Mittrücker H-W, Feger U, Welte SA, Yokoyama WM, Spies T et al. Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo. J IMMUNOL. 2005 Jul 15;175(2):720-9.

Bibtex

@article{46d84178d2c44d97a4469384a61697d9,
title = "Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo",
abstract = "The immunoreceptor NKG2D stimulates activation of cytotoxic lymphocytes upon engagement with MHC class I-related NKG2D ligands of which at least some are expressed inducibly upon exposure to carcinogens, cell stress, or viruses. In this study, we investigated consequences of a persistent NKG2D ligand expression in vivo by using transgenic mice expressing MHC class I chain-related protein A (MICA) under control of the H2-K(b) promoter. Although MICA functions as a potent activating ligand of mouse NKG2D, H2-K(b)-MICA mice appear healthy without aberrations in lymphocyte subsets. However, NKG2D-mediated cytotoxicity of H2-K(b)-MICA NK cells is severely impaired in vitro and in vivo. This deficiency concurs with a pronounced down-regulation of surface NKG2D that is also seen on activated CD8 T cells. As a consequence, H2-K(b)-MICA mice fail to reject MICA-expressing tumors and to mount normal CD8 T cell responses upon Listeria infection emphasizing the importance of NKG2D in immunity against tumors and intracellular infectious agents.",
keywords = "Animals, CD8-Positive T-Lymphocytes, CHO Cells, Cell Line, Tumor, Coculture Techniques, Cricetinae, Cytotoxicity, Immunologic, Down-Regulation, Graft Rejection, H-2 Antigens, Histocompatibility Antigens Class I, Immunity, Innate, Killer Cells, Natural, Listeriosis, Lymphocyte Activation, Lymphoma, T-Cell, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Knockout, Mice, Transgenic, NK Cell Lectin-Like Receptor Subfamily K, Receptors, Immunologic, Receptors, Natural Killer Cell",
author = "Katrin Wiemann and Hans-Willi Mittr{\"u}cker and Ute Feger and Welte, {Stefan A} and Yokoyama, {Wayne M} and Thomas Spies and Hans-Georg Rammensee and Alexander Steinle",
year = "2005",
month = jul,
day = "15",
language = "English",
volume = "175",
pages = "720--9",
journal = "J IMMUNOL",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "2",

}

RIS

TY - JOUR

T1 - Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo

AU - Wiemann, Katrin

AU - Mittrücker, Hans-Willi

AU - Feger, Ute

AU - Welte, Stefan A

AU - Yokoyama, Wayne M

AU - Spies, Thomas

AU - Rammensee, Hans-Georg

AU - Steinle, Alexander

PY - 2005/7/15

Y1 - 2005/7/15

N2 - The immunoreceptor NKG2D stimulates activation of cytotoxic lymphocytes upon engagement with MHC class I-related NKG2D ligands of which at least some are expressed inducibly upon exposure to carcinogens, cell stress, or viruses. In this study, we investigated consequences of a persistent NKG2D ligand expression in vivo by using transgenic mice expressing MHC class I chain-related protein A (MICA) under control of the H2-K(b) promoter. Although MICA functions as a potent activating ligand of mouse NKG2D, H2-K(b)-MICA mice appear healthy without aberrations in lymphocyte subsets. However, NKG2D-mediated cytotoxicity of H2-K(b)-MICA NK cells is severely impaired in vitro and in vivo. This deficiency concurs with a pronounced down-regulation of surface NKG2D that is also seen on activated CD8 T cells. As a consequence, H2-K(b)-MICA mice fail to reject MICA-expressing tumors and to mount normal CD8 T cell responses upon Listeria infection emphasizing the importance of NKG2D in immunity against tumors and intracellular infectious agents.

AB - The immunoreceptor NKG2D stimulates activation of cytotoxic lymphocytes upon engagement with MHC class I-related NKG2D ligands of which at least some are expressed inducibly upon exposure to carcinogens, cell stress, or viruses. In this study, we investigated consequences of a persistent NKG2D ligand expression in vivo by using transgenic mice expressing MHC class I chain-related protein A (MICA) under control of the H2-K(b) promoter. Although MICA functions as a potent activating ligand of mouse NKG2D, H2-K(b)-MICA mice appear healthy without aberrations in lymphocyte subsets. However, NKG2D-mediated cytotoxicity of H2-K(b)-MICA NK cells is severely impaired in vitro and in vivo. This deficiency concurs with a pronounced down-regulation of surface NKG2D that is also seen on activated CD8 T cells. As a consequence, H2-K(b)-MICA mice fail to reject MICA-expressing tumors and to mount normal CD8 T cell responses upon Listeria infection emphasizing the importance of NKG2D in immunity against tumors and intracellular infectious agents.

KW - Animals

KW - CD8-Positive T-Lymphocytes

KW - CHO Cells

KW - Cell Line, Tumor

KW - Coculture Techniques

KW - Cricetinae

KW - Cytotoxicity, Immunologic

KW - Down-Regulation

KW - Graft Rejection

KW - H-2 Antigens

KW - Histocompatibility Antigens Class I

KW - Immunity, Innate

KW - Killer Cells, Natural

KW - Listeriosis

KW - Lymphocyte Activation

KW - Lymphoma, T-Cell

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Inbred CBA

KW - Mice, Knockout

KW - Mice, Transgenic

KW - NK Cell Lectin-Like Receptor Subfamily K

KW - Receptors, Immunologic

KW - Receptors, Natural Killer Cell

M3 - SCORING: Journal article

C2 - 16002667

VL - 175

SP - 720

EP - 729

JO - J IMMUNOL

JF - J IMMUNOL

SN - 0022-1767

IS - 2

ER -