Systematically investigating the role of context on effect replicability in reinstatement of fear in humans

TY - JOUR

T1 - Systematically investigating the role of context on effect replicability in reinstatement of fear in humans

AU - Sjouwerman, R

AU - Lonsdorf, T B

N1 - Copyright © 2023 Elsevier Ltd. All rights reserved.

PY - 2023/3

Y1 - 2023/3

N2 - Context is crucial in guiding behavior in an ever-changing world and contextual information plays a crucial role in associative learning processes. For instance, the return of fear (RoF) after successful extinction, which is used to study the mechanisms underlying relapse phenomena in fear- and stress-related disorders in an experimental model, is known to be context dependent as evident from phenomena such as renewal (contextual change) and reinstatement (re-exposure to an aversive event). Human adaptions of reinstatement paradigms have resulted in mixed findings: CS specific as well as unspecific RoF or unexpected "reinstated" conditioned responding in no reinstatement US control groups. Here, we systematically investigate the role of context (i.e., cue-context compound) on reinstatement-induced RoF in a human differential fear conditioning paradigm using subjective and psychophysiological measures in a large sample (N = 212) including reinstatement and control groups. Overall, response patterns in reinstatement-groups mirrored results from single-cue rodent work. Yet, only generalized, not differential RoF was observed. Remarkably, depending on outcome measure RoF was also observed under identical experimental context conditions without US-re-exposure, underlining effects of contextual change beyond the reinstatement-US and challenging reinstatement research in human subjects and highlight that future reinstatement work should focus on the operationalization of context.

AB - Context is crucial in guiding behavior in an ever-changing world and contextual information plays a crucial role in associative learning processes. For instance, the return of fear (RoF) after successful extinction, which is used to study the mechanisms underlying relapse phenomena in fear- and stress-related disorders in an experimental model, is known to be context dependent as evident from phenomena such as renewal (contextual change) and reinstatement (re-exposure to an aversive event). Human adaptions of reinstatement paradigms have resulted in mixed findings: CS specific as well as unspecific RoF or unexpected "reinstated" conditioned responding in no reinstatement US control groups. Here, we systematically investigate the role of context (i.e., cue-context compound) on reinstatement-induced RoF in a human differential fear conditioning paradigm using subjective and psychophysiological measures in a large sample (N = 212) including reinstatement and control groups. Overall, response patterns in reinstatement-groups mirrored results from single-cue rodent work. Yet, only generalized, not differential RoF was observed. Remarkably, depending on outcome measure RoF was also observed under identical experimental context conditions without US-re-exposure, underlining effects of contextual change beyond the reinstatement-US and challenging reinstatement research in human subjects and highlight that future reinstatement work should focus on the operationalization of context.

U2 - 10.1016/j.brat.2023.104256

DO - 10.1016/j.brat.2023.104256

M3 - SCORING: Journal article

C2 - 36736196

VL - 162

SP - 104256

JO - BEHAV RES THER

JF - BEHAV RES THER

SN - 0005-7967

ER -