Syndecan-1 as a biomarker for sepsis survival after major abdominal surgery
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Syndecan-1 as a biomarker for sepsis survival after major abdominal surgery. / Holzmann, Maximilian S; Winkler, Martin S; Strunden, Mike S; Izbicki, Jakob R; Schoen, Gerhard; Greiwe, Gillis; Pinnschmidt, Hans O; Poppe, Annika; Saugel, Bernd; Daum, Guenter; Goetz, Alwin E; Heckel, Kai.
in: BIOMARK MED, Jahrgang 12, Nr. 2, 02.2018, S. 119-127.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Syndecan-1 as a biomarker for sepsis survival after major abdominal surgery
AU - Holzmann, Maximilian S
AU - Winkler, Martin S
AU - Strunden, Mike S
AU - Izbicki, Jakob R
AU - Schoen, Gerhard
AU - Greiwe, Gillis
AU - Pinnschmidt, Hans O
AU - Poppe, Annika
AU - Saugel, Bernd
AU - Daum, Guenter
AU - Goetz, Alwin E
AU - Heckel, Kai
PY - 2018/2
Y1 - 2018/2
N2 - AIM: Sepsis is a serious complication following surgery and identification of patients at risk is of high importance. Syndecan-1 (sSDC1) levels are known to be elevated during sepsis.MATERIALS & METHODS: Fifty-five patients scheduled for major abdominal surgery were prospectively included and sSDC1 concentrations were measured during hospital stay.RESULTS: Patients with postoperative sepsis showed a continued increase of sSDC1 levels and exhibited higher median sSDC1 concentrations at day 1 compared with nonseptic patients 90.3 versus 16.5 ng/ml. A significant association of sSDC1 levels with the incidence of sepsis and death was demonstrated.CONCLUSION: This study identifies sSDC1 as potential biomarker for sepsis and survival after abdominal surgery.
AB - AIM: Sepsis is a serious complication following surgery and identification of patients at risk is of high importance. Syndecan-1 (sSDC1) levels are known to be elevated during sepsis.MATERIALS & METHODS: Fifty-five patients scheduled for major abdominal surgery were prospectively included and sSDC1 concentrations were measured during hospital stay.RESULTS: Patients with postoperative sepsis showed a continued increase of sSDC1 levels and exhibited higher median sSDC1 concentrations at day 1 compared with nonseptic patients 90.3 versus 16.5 ng/ml. A significant association of sSDC1 levels with the incidence of sepsis and death was demonstrated.CONCLUSION: This study identifies sSDC1 as potential biomarker for sepsis and survival after abdominal surgery.
KW - Journal Article
U2 - 10.2217/bmm-2017-0231
DO - 10.2217/bmm-2017-0231
M3 - SCORING: Journal article
C2 - 29327601
VL - 12
SP - 119
EP - 127
JO - BIOMARK MED
JF - BIOMARK MED
SN - 1752-0363
IS - 2
ER -