Synaptic mechanisms of pattern completion in the hippocampal CA3 network

Segundo Jose Guzman; Alois Schlögl; Michael Frotscher; Peter Jonas

doi:10.1126/science.aaf1836

Synaptic mechanisms of pattern completion in the hippocampal CA3 network

Standard

Synaptic mechanisms of pattern completion in the hippocampal CA3 network. / Guzman, Segundo Jose; Schlögl, Alois; Frotscher, Michael; Jonas, Peter.

in: SCIENCE, Jahrgang 353, Nr. 6304, 09.09.2016, S. 1117-23.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Guzman, SJ, Schlögl, A, Frotscher, M & Jonas, P 2016, 'Synaptic mechanisms of pattern completion in the hippocampal CA3 network', SCIENCE, Jg. 353, Nr. 6304, S. 1117-23. https://doi.org/10.1126/science.aaf1836

APA

Guzman, S. J., Schlögl, A., Frotscher, M., & Jonas, P. (2016). Synaptic mechanisms of pattern completion in the hippocampal CA3 network. SCIENCE, 353(6304), 1117-23. https://doi.org/10.1126/science.aaf1836

Vancouver

Guzman SJ, Schlögl A, Frotscher M, Jonas P. Synaptic mechanisms of pattern completion in the hippocampal CA3 network. SCIENCE. 2016 Sep 9;353(6304):1117-23. https://doi.org/10.1126/science.aaf1836

Bibtex

@article{f1397e163cdb45439683fdef5100b077,

title = "Synaptic mechanisms of pattern completion in the hippocampal CA3 network",

abstract = "The hippocampal CA3 region plays a key role in learning and memory. Recurrent CA3-CA3 synapses are thought to be the subcellular substrate of pattern completion. However, the synaptic mechanisms of this network computation remain enigmatic. To investigate these mechanisms, we combined functional connectivity analysis with network modeling. Simultaneous recording from up to eight CA3 pyramidal neurons revealed that connectivity was sparse, spatially uniform, and highly enriched in disynaptic motifs (reciprocal, convergence, divergence, and chain motifs). Unitary connections were composed of one or two synaptic contacts, suggesting efficient use of postsynaptic space. Real-size modeling indicated that CA3 networks with sparse connectivity, disynaptic motifs, and single-contact connections robustly generated pattern completion. Thus, macro- and microconnectivity contribute to efficient memory storage and retrieval in hippocampal networks.",

keywords = "Journal Article, Synapses, Hippocampus/physiology",

author = "Guzman, {Segundo Jose} and Alois Schl{\"o}gl and Michael Frotscher and Peter Jonas",

note = "Copyright {\textcopyright} 2016, American Association for the Advancement of Science.",

year = "2016",

month = sep,

day = "9",

doi = "10.1126/science.aaf1836",

language = "English",

volume = "353",

pages = "1117--23",

journal = "SCIENCE",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6304",

}

RIS

TY - JOUR

T1 - Synaptic mechanisms of pattern completion in the hippocampal CA3 network

AU - Guzman, Segundo Jose

AU - Schlögl, Alois

AU - Frotscher, Michael

AU - Jonas, Peter

PY - 2016/9/9

Y1 - 2016/9/9

N2 - The hippocampal CA3 region plays a key role in learning and memory. Recurrent CA3-CA3 synapses are thought to be the subcellular substrate of pattern completion. However, the synaptic mechanisms of this network computation remain enigmatic. To investigate these mechanisms, we combined functional connectivity analysis with network modeling. Simultaneous recording from up to eight CA3 pyramidal neurons revealed that connectivity was sparse, spatially uniform, and highly enriched in disynaptic motifs (reciprocal, convergence, divergence, and chain motifs). Unitary connections were composed of one or two synaptic contacts, suggesting efficient use of postsynaptic space. Real-size modeling indicated that CA3 networks with sparse connectivity, disynaptic motifs, and single-contact connections robustly generated pattern completion. Thus, macro- and microconnectivity contribute to efficient memory storage and retrieval in hippocampal networks.

AB - The hippocampal CA3 region plays a key role in learning and memory. Recurrent CA3-CA3 synapses are thought to be the subcellular substrate of pattern completion. However, the synaptic mechanisms of this network computation remain enigmatic. To investigate these mechanisms, we combined functional connectivity analysis with network modeling. Simultaneous recording from up to eight CA3 pyramidal neurons revealed that connectivity was sparse, spatially uniform, and highly enriched in disynaptic motifs (reciprocal, convergence, divergence, and chain motifs). Unitary connections were composed of one or two synaptic contacts, suggesting efficient use of postsynaptic space. Real-size modeling indicated that CA3 networks with sparse connectivity, disynaptic motifs, and single-contact connections robustly generated pattern completion. Thus, macro- and microconnectivity contribute to efficient memory storage and retrieval in hippocampal networks.

KW - Journal Article

KW - Synapses

KW - Hippocampus/physiology

U2 - 10.1126/science.aaf1836

DO - 10.1126/science.aaf1836

M3 - SCORING: Journal article

C2 - 27609885

VL - 353

SP - 1117

EP - 1123

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 6304

ER -