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Symptoms and probabilistic anatomical mapping of lacunar infarcts

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Symptoms and probabilistic anatomical mapping of lacunar infarcts. / Barow, Ewgenia; Pinnschmidt, Hans; Boutitie, Florent; Königsberg, Alina; Ebinger, Martin; Endres, Matthias; Fiebach, Jochen B; Fiehler, Jens; Thijs, Vincent; Lemmens, Robin; Muir, Keith W; Nighoghossian, Norbert; Pedraza, Salvador; Simonsen, Claus Z; Gerloff, Christian; Thomalla, Götz; Cheng, Bastian; WAKE-UP Investigators.

in: Neurol Res Pract, Jahrgang 2, 2020, S. 21.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Barow, E, Pinnschmidt, H, Boutitie, F, Königsberg, A, Ebinger, M, Endres, M, Fiebach, JB, Fiehler, J, Thijs, V, Lemmens, R, Muir, KW, Nighoghossian, N, Pedraza, S, Simonsen, CZ, Gerloff, C, Thomalla, G, Cheng, B & WAKE-UP Investigators 2020, 'Symptoms and probabilistic anatomical mapping of lacunar infarcts', Neurol Res Pract, Jg. 2, S. 21. https://doi.org/10.1186/s42466-020-00068-y

APA

Barow, E., Pinnschmidt, H., Boutitie, F., Königsberg, A., Ebinger, M., Endres, M., Fiebach, J. B., Fiehler, J., Thijs, V., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S., Simonsen, C. Z., Gerloff, C., Thomalla, G., Cheng, B., & WAKE-UP Investigators (2020). Symptoms and probabilistic anatomical mapping of lacunar infarcts. Neurol Res Pract, 2, 21. https://doi.org/10.1186/s42466-020-00068-y

Vancouver

Barow E, Pinnschmidt H, Boutitie F, Königsberg A, Ebinger M, Endres M et al. Symptoms and probabilistic anatomical mapping of lacunar infarcts. Neurol Res Pract. 2020;2:21. https://doi.org/10.1186/s42466-020-00068-y

Bibtex

@article{56097da4ede14868b685d6d8e3758907,
title = "Symptoms and probabilistic anatomical mapping of lacunar infarcts",
abstract = "Background: The anatomical distribution of acute lacunar infarcts has mainly been studied for supratentorial lesions. In addition, little is known about the association with distinct stroke symptoms, not summarized as classical lacunar syndromes. We aimed to describe the spatial lesion distribution of acute supra- and infratentorial lacunar infarcts and their association with stroke symptoms in patients eligible for thrombolysis.Methods: All patients enrolled in the WAKE-UP trial (efficacy and safety of magnetic resonance imaging [MRI]-based thrombolysis in wake-up stroke) were screened for lacunar infarcts on diffusion-weighted imaging (DWI). The relationship between the anatomical distribution of supra- and infratentorial lacunar infarcts, their demographic characteristics and acute stroke symptoms, defined by the National Institutes of Health Stroke Scale (NIHSS) score, were correlated and compared.Results: Maps of lesion distribution from 224 lacunar infarct patients (76 [33.9%] females, mean age [standard deviation] of 63.4 [11.5] years) were generated using computational image mapping methods. Median infarct volume was 0.73 ml (interquartile range [IQR] 0.37-1.15 ml). Median NIHSS sum score on hospital arrival was 4 (IQR 3-6). 165 (73.7%) patients had lacunar infarcts in the supratentorial deep white or grey matter, while 59 (26.3%) patients had infratentorial lacunar infarcts. Patients with supratentorial lacunar infarcts presented with a significantly lower occurrence of deficits in the NIHSS items gaze (p < 0.001) and dysarthria (p = 0.008), but had more often a paresis of the left arm (p = 0.009) and left leg (p = 0.068) compared to patients with infratentorial infarcts.Conclusions: The anatomical lesion distribution of lacunar infarcts reveals a distinct pattern and supports an association of localization with different stroke symptoms.Trial registration: NCT01525290.",
author = "Ewgenia Barow and Hans Pinnschmidt and Florent Boutitie and Alina K{\"o}nigsberg and Martin Ebinger and Matthias Endres and Fiebach, {Jochen B} and Jens Fiehler and Vincent Thijs and Robin Lemmens and Muir, {Keith W} and Norbert Nighoghossian and Salvador Pedraza and Simonsen, {Claus Z} and Christian Gerloff and G{\"o}tz Thomalla and Bastian Cheng and {WAKE-UP Investigators}",
note = "{\textcopyright} The Author(s) 2020.",
year = "2020",
doi = "10.1186/s42466-020-00068-y",
language = "English",
volume = "2",
pages = "21",
journal = "Neurol Res Pract",
issn = "2524-3489",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Symptoms and probabilistic anatomical mapping of lacunar infarcts

AU - Barow, Ewgenia

AU - Pinnschmidt, Hans

AU - Boutitie, Florent

AU - Königsberg, Alina

AU - Ebinger, Martin

AU - Endres, Matthias

AU - Fiebach, Jochen B

AU - Fiehler, Jens

AU - Thijs, Vincent

AU - Lemmens, Robin

AU - Muir, Keith W

AU - Nighoghossian, Norbert

AU - Pedraza, Salvador

AU - Simonsen, Claus Z

AU - Gerloff, Christian

AU - Thomalla, Götz

AU - Cheng, Bastian

AU - WAKE-UP Investigators

N1 - © The Author(s) 2020.

PY - 2020

Y1 - 2020

N2 - Background: The anatomical distribution of acute lacunar infarcts has mainly been studied for supratentorial lesions. In addition, little is known about the association with distinct stroke symptoms, not summarized as classical lacunar syndromes. We aimed to describe the spatial lesion distribution of acute supra- and infratentorial lacunar infarcts and their association with stroke symptoms in patients eligible for thrombolysis.Methods: All patients enrolled in the WAKE-UP trial (efficacy and safety of magnetic resonance imaging [MRI]-based thrombolysis in wake-up stroke) were screened for lacunar infarcts on diffusion-weighted imaging (DWI). The relationship between the anatomical distribution of supra- and infratentorial lacunar infarcts, their demographic characteristics and acute stroke symptoms, defined by the National Institutes of Health Stroke Scale (NIHSS) score, were correlated and compared.Results: Maps of lesion distribution from 224 lacunar infarct patients (76 [33.9%] females, mean age [standard deviation] of 63.4 [11.5] years) were generated using computational image mapping methods. Median infarct volume was 0.73 ml (interquartile range [IQR] 0.37-1.15 ml). Median NIHSS sum score on hospital arrival was 4 (IQR 3-6). 165 (73.7%) patients had lacunar infarcts in the supratentorial deep white or grey matter, while 59 (26.3%) patients had infratentorial lacunar infarcts. Patients with supratentorial lacunar infarcts presented with a significantly lower occurrence of deficits in the NIHSS items gaze (p < 0.001) and dysarthria (p = 0.008), but had more often a paresis of the left arm (p = 0.009) and left leg (p = 0.068) compared to patients with infratentorial infarcts.Conclusions: The anatomical lesion distribution of lacunar infarcts reveals a distinct pattern and supports an association of localization with different stroke symptoms.Trial registration: NCT01525290.

AB - Background: The anatomical distribution of acute lacunar infarcts has mainly been studied for supratentorial lesions. In addition, little is known about the association with distinct stroke symptoms, not summarized as classical lacunar syndromes. We aimed to describe the spatial lesion distribution of acute supra- and infratentorial lacunar infarcts and their association with stroke symptoms in patients eligible for thrombolysis.Methods: All patients enrolled in the WAKE-UP trial (efficacy and safety of magnetic resonance imaging [MRI]-based thrombolysis in wake-up stroke) were screened for lacunar infarcts on diffusion-weighted imaging (DWI). The relationship between the anatomical distribution of supra- and infratentorial lacunar infarcts, their demographic characteristics and acute stroke symptoms, defined by the National Institutes of Health Stroke Scale (NIHSS) score, were correlated and compared.Results: Maps of lesion distribution from 224 lacunar infarct patients (76 [33.9%] females, mean age [standard deviation] of 63.4 [11.5] years) were generated using computational image mapping methods. Median infarct volume was 0.73 ml (interquartile range [IQR] 0.37-1.15 ml). Median NIHSS sum score on hospital arrival was 4 (IQR 3-6). 165 (73.7%) patients had lacunar infarcts in the supratentorial deep white or grey matter, while 59 (26.3%) patients had infratentorial lacunar infarcts. Patients with supratentorial lacunar infarcts presented with a significantly lower occurrence of deficits in the NIHSS items gaze (p < 0.001) and dysarthria (p = 0.008), but had more often a paresis of the left arm (p = 0.009) and left leg (p = 0.068) compared to patients with infratentorial infarcts.Conclusions: The anatomical lesion distribution of lacunar infarcts reveals a distinct pattern and supports an association of localization with different stroke symptoms.Trial registration: NCT01525290.

U2 - 10.1186/s42466-020-00068-y

DO - 10.1186/s42466-020-00068-y

M3 - SCORING: Journal article

C2 - 33324925

VL - 2

SP - 21

JO - Neurol Res Pract

JF - Neurol Res Pract

SN - 2524-3489

ER -