Sustained virological response after early antiviral treatment of acute hepatitis C virus and HIV coinfection.
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Sustained virological response after early antiviral treatment of acute hepatitis C virus and HIV coinfection. / Schulze Zur Wiesch, Julian; Pieper, Dorothea; Stahmer, Ingrid; Eiermann, Thomas; Buggisch, Peter; Lohse, Ansgar W.; Hauber, Joachim; van Lunzen, Jan.
in: CLIN INFECT DIS, Jahrgang 49, Nr. 3, 3, 2009, S. 466-472.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Sustained virological response after early antiviral treatment of acute hepatitis C virus and HIV coinfection.
AU - Schulze Zur Wiesch, Julian
AU - Pieper, Dorothea
AU - Stahmer, Ingrid
AU - Eiermann, Thomas
AU - Buggisch, Peter
AU - Lohse, Ansgar W.
AU - Hauber, Joachim
AU - van Lunzen, Jan
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Limited data exist describing the clinical outcome and immunological response primed during simultaneously acquired acute hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection. We present detailed clinical and immunological analysis of 3 individuals after concomitant infection with acute HCV and primary HIV. METHODS: In addition to longitudinal clinical parameters, virus-specific T cell responses were assessed using Elispot, standard proliferative (carboxyfluorescein diacetate succinimidyl ester), and in vitro CD4(+) T cell assays. RESULTS: In all patients, anti-HCV treatment was started with pegylated interferon-alpha, and antiretroviral therapy was coadministered early during primary infection. HCV viremia was cleared under therapy with pegylated interferon-alpha in all 3 cases. In 2 patients, HIV replication was contained even after antiretroviral therapy had been interrupted, which was associated with strong HIV-specific CD8(+) and CD4(+) T cell responses. In these 2 patients, multispecific HCV CD4(+) T cell responses could also be detected. No HCV-specific CD4(+) T cell responses were detected in the third patient, who also had the lowest nadir CD4(+) cell count during primary HIV infection (
AB - BACKGROUND: Limited data exist describing the clinical outcome and immunological response primed during simultaneously acquired acute hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection. We present detailed clinical and immunological analysis of 3 individuals after concomitant infection with acute HCV and primary HIV. METHODS: In addition to longitudinal clinical parameters, virus-specific T cell responses were assessed using Elispot, standard proliferative (carboxyfluorescein diacetate succinimidyl ester), and in vitro CD4(+) T cell assays. RESULTS: In all patients, anti-HCV treatment was started with pegylated interferon-alpha, and antiretroviral therapy was coadministered early during primary infection. HCV viremia was cleared under therapy with pegylated interferon-alpha in all 3 cases. In 2 patients, HIV replication was contained even after antiretroviral therapy had been interrupted, which was associated with strong HIV-specific CD8(+) and CD4(+) T cell responses. In these 2 patients, multispecific HCV CD4(+) T cell responses could also be detected. No HCV-specific CD4(+) T cell responses were detected in the third patient, who also had the lowest nadir CD4(+) cell count during primary HIV infection (
M3 - SCORING: Zeitschriftenaufsatz
VL - 49
SP - 466
EP - 472
JO - CLIN INFECT DIS
JF - CLIN INFECT DIS
SN - 1058-4838
IS - 3
M1 - 3
ER -
