Susceptibility variants for male-pattern baldness on chromosome 20p11.
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Susceptibility variants for male-pattern baldness on chromosome 20p11. / Hillmer, Axel M; Brockschmidt, Felix F; Hanneken, Sandra; Eigelshoven, Sibylle; Steffens, Michael; Flaquer, Antonia; Herms, Stefan; Becker, Tim; Kortüm, Anne-Katrin; Nyholt, Dale R; Zhao, Zhen Zhen; Montgomery, Grant W; Martin, Nicholas G; Mühleisen, Thomas W; Alblas, Margrieta A; Moebus, Susanne; Jöckel, Karl-Heinz; Bröcker-Preuss, Martina; Erbel, Raimund; Reinartz, Roman; Betz, Regina C; Cichon, Sven; Propping, Peter; Baur, Max P; Wienker, Thomas F; Kruse, Roland; Nöthen, Markus M.
in: NAT GENET, Jahrgang 40, Nr. 11, 11, 2008, S. 1279-1281.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Susceptibility variants for male-pattern baldness on chromosome 20p11.
AU - Hillmer, Axel M
AU - Brockschmidt, Felix F
AU - Hanneken, Sandra
AU - Eigelshoven, Sibylle
AU - Steffens, Michael
AU - Flaquer, Antonia
AU - Herms, Stefan
AU - Becker, Tim
AU - Kortüm, Anne-Katrin
AU - Nyholt, Dale R
AU - Zhao, Zhen Zhen
AU - Montgomery, Grant W
AU - Martin, Nicholas G
AU - Mühleisen, Thomas W
AU - Alblas, Margrieta A
AU - Moebus, Susanne
AU - Jöckel, Karl-Heinz
AU - Bröcker-Preuss, Martina
AU - Erbel, Raimund
AU - Reinartz, Roman
AU - Betz, Regina C
AU - Cichon, Sven
AU - Propping, Peter
AU - Baur, Max P
AU - Wienker, Thomas F
AU - Kruse, Roland
AU - Nöthen, Markus M
PY - 2008
Y1 - 2008
N2 - We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.
AB - We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.
M3 - SCORING: Zeitschriftenaufsatz
VL - 40
SP - 1279
EP - 1281
JO - NAT GENET
JF - NAT GENET
SN - 1061-4036
IS - 11
M1 - 11
ER -