Survival advantage of Asian metastatic prostate cancer patients treated with external beam radiotherapy over other races/ethnicities
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Survival advantage of Asian metastatic prostate cancer patients treated with external beam radiotherapy over other races/ethnicities. / Würnschimmel, Christoph; Wenzel, Mike; Collà Ruvolo, Claudia; Nocera, Luigi; Tian, Zhe; Saad, Fred; Briganti, Alberto; Shariat, Shahrokh F; Mandel, Philipp; Chun, Felix K H; Tilki, Derya; Graefen, Markus; Karakiewicz, Pierre I.
in: WORLD J UROL, Jahrgang 39, Nr. 10, 10.2021, S. 3781-3787.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Survival advantage of Asian metastatic prostate cancer patients treated with external beam radiotherapy over other races/ethnicities
AU - Würnschimmel, Christoph
AU - Wenzel, Mike
AU - Collà Ruvolo, Claudia
AU - Nocera, Luigi
AU - Tian, Zhe
AU - Saad, Fred
AU - Briganti, Alberto
AU - Shariat, Shahrokh F
AU - Mandel, Philipp
AU - Chun, Felix K H
AU - Tilki, Derya
AU - Graefen, Markus
AU - Karakiewicz, Pierre I
N1 - © 2021. The Author(s).
PY - 2021/10
Y1 - 2021/10
N2 - PURPOSE: To assess the effect of race/ethnicity in cancer-specific mortality (CSM) adjusted for other-cause mortality (OCM) in metastatic prostate cancer patients (mPCa) treated with external beam radiotherapy (EBRT) to the prostate.METHODS: We relied on the Surveillance, Epidemiology, and End Results (SEER) database to identify Caucasian, African-American, Hispanic/Latino and Asian mPCa patients treated by EBRT between 2004 and 2016. Cumulative incidence plots displayed CSM after adjustment for OCM according to race/ethnicity. Propensity score matching accounted for patient age, prostate-specific antigen, clinical T and N stages, Gleason Grade Groups and M1 substages. OCM adjusted multivariable analyses tested for differences in CSM in African-Americans, Hispanic/Latinos and Asians relative to Cauacasians.RESULTS: After 3:1 propensity score matching and OCM adjustment, Asians exhibited lower CSM at 60 and 120 months (48.2 and 60.0%, respectively) compared to Caucasians (66.7 and 79.4%, respectively, p < 0.001). In OCM adjusted multivariable analyses, Asian race/ethnicity was associated with lower CSM (HR 0.66, CI 0.52-0.83, p < 0.001). Conversely, African-American and Hispanic/Latino race/ethnicity did not affect CSM. OCM rates were comparable between examined races/ethnicities.CONCLUSION: In the setting of mPCa treated with EBRT, Asians exhibit lower CSM than Caucasians, African-Americans and Hispanic/Latinos. This observation may warrant consideration in prognostic stratification schemes for newly diagnosed mPCa patients.
AB - PURPOSE: To assess the effect of race/ethnicity in cancer-specific mortality (CSM) adjusted for other-cause mortality (OCM) in metastatic prostate cancer patients (mPCa) treated with external beam radiotherapy (EBRT) to the prostate.METHODS: We relied on the Surveillance, Epidemiology, and End Results (SEER) database to identify Caucasian, African-American, Hispanic/Latino and Asian mPCa patients treated by EBRT between 2004 and 2016. Cumulative incidence plots displayed CSM after adjustment for OCM according to race/ethnicity. Propensity score matching accounted for patient age, prostate-specific antigen, clinical T and N stages, Gleason Grade Groups and M1 substages. OCM adjusted multivariable analyses tested for differences in CSM in African-Americans, Hispanic/Latinos and Asians relative to Cauacasians.RESULTS: After 3:1 propensity score matching and OCM adjustment, Asians exhibited lower CSM at 60 and 120 months (48.2 and 60.0%, respectively) compared to Caucasians (66.7 and 79.4%, respectively, p < 0.001). In OCM adjusted multivariable analyses, Asian race/ethnicity was associated with lower CSM (HR 0.66, CI 0.52-0.83, p < 0.001). Conversely, African-American and Hispanic/Latino race/ethnicity did not affect CSM. OCM rates were comparable between examined races/ethnicities.CONCLUSION: In the setting of mPCa treated with EBRT, Asians exhibit lower CSM than Caucasians, African-Americans and Hispanic/Latinos. This observation may warrant consideration in prognostic stratification schemes for newly diagnosed mPCa patients.
U2 - 10.1007/s00345-021-03720-7
DO - 10.1007/s00345-021-03720-7
M3 - SCORING: Journal article
C2 - 33978812
VL - 39
SP - 3781
EP - 3787
JO - WORLD J UROL
JF - WORLD J UROL
SN - 0724-4983
IS - 10
ER -