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Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression

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Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression. / Hagel, Christian; Treszl, András; Fehlert, Julia; Harder, Jonas; von Haxthausen, Franziska; Kern, Meike; von Bueren, André O.; Kordes, Uwe.

in: J NEURO-ONCOL, Jahrgang 112, Nr. 2, 01.04.2013, S. 191-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hagel, C, Treszl, A, Fehlert, J, Harder, J, von Haxthausen, F, Kern, M, von Bueren, AO & Kordes, U 2013, 'Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression', J NEURO-ONCOL, Jg. 112, Nr. 2, S. 191-7. https://doi.org/10.1007/s11060-013-1062-1

APA

Hagel, C., Treszl, A., Fehlert, J., Harder, J., von Haxthausen, F., Kern, M., von Bueren, A. O., & Kordes, U. (2013). Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression. J NEURO-ONCOL, 112(2), 191-7. https://doi.org/10.1007/s11060-013-1062-1

Vancouver

Hagel C, Treszl A, Fehlert J, Harder J, von Haxthausen F, Kern M et al. Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression. J NEURO-ONCOL. 2013 Apr 1;112(2):191-7. https://doi.org/10.1007/s11060-013-1062-1

Bibtex

@article{a2002f818e894b15877d364deae23edd,
title = "Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression",
abstract = "Ependymomas comprise 8 % of all intracranial tumors in children <15 years. Recent studies revealed that some supratentorial ependymomas express neuronal antigens and that high expression of neurofilament protein light polypeptide (NEFL) correlates with better clinical outcome. We retrospectively analyzed an expanded panel of proteins in 6 supratentorial, 15 posterior fossa and 4 spinal pediatric ependymomas by immunohistochemistry. Expression of high and low affinity neurotrophin receptors TrkA (NTRK1) and p75 (NGFR), pan-neuronal markers NeuN (RBFOX3) and synaptophysin, radial glial marker SOX9, adhesion molecules CD56 (NCAM) and CD44, junctional protein connexin 43 (GJA1), glial fibrillary acidic protein (GFAP), epithelial membrane antigen and proliferation associated antigen Ki-67 were evaluated in a semi-quantitative or quantitative (Ki-67 and NeuN-index) fashion. We found p75 and NeuN to be expressed at significantly higher levels in supratentorial versus infratentorial tumors and GFAP to be expressed at significantly higher levels in infratentorial lesions. In conclusion, immunohistochemical expression of p75, NeuN and GFAP differed in ependymomas depending on tumor topography supporting the view of divergent cells of origin. However, because of the small sample size the results are of preliminary nature and replication in a larger cohort would be desirable.",
keywords = "Adolescent, Antigens, Nuclear, Child, Child, Preschool, Ependymoma, Female, Follow-Up Studies, Glial Fibrillary Acidic Protein, Humans, Immunoenzyme Techniques, Infant, Infratentorial Neoplasms, Male, Neoplasm Grading, Nerve Tissue Proteins, Prognosis, Receptors, Nerve Growth Factor, Retrospective Studies, Supratentorial Neoplasms, Tumor Markers, Biological",
author = "Christian Hagel and Andr{\'a}s Treszl and Julia Fehlert and Jonas Harder and {von Haxthausen}, Franziska and Meike Kern and {von Bueren}, {Andr{\'e} O.} and Uwe Kordes",
year = "2013",
month = apr,
day = "1",
doi = "10.1007/s11060-013-1062-1",
language = "English",
volume = "112",
pages = "191--7",
journal = "J NEURO-ONCOL",
issn = "0167-594X",
publisher = "Kluwer Academic Publishers",
number = "2",

}

RIS

TY - JOUR

T1 - Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression

AU - Hagel, Christian

AU - Treszl, András

AU - Fehlert, Julia

AU - Harder, Jonas

AU - von Haxthausen, Franziska

AU - Kern, Meike

AU - von Bueren, André O.

AU - Kordes, Uwe

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Ependymomas comprise 8 % of all intracranial tumors in children <15 years. Recent studies revealed that some supratentorial ependymomas express neuronal antigens and that high expression of neurofilament protein light polypeptide (NEFL) correlates with better clinical outcome. We retrospectively analyzed an expanded panel of proteins in 6 supratentorial, 15 posterior fossa and 4 spinal pediatric ependymomas by immunohistochemistry. Expression of high and low affinity neurotrophin receptors TrkA (NTRK1) and p75 (NGFR), pan-neuronal markers NeuN (RBFOX3) and synaptophysin, radial glial marker SOX9, adhesion molecules CD56 (NCAM) and CD44, junctional protein connexin 43 (GJA1), glial fibrillary acidic protein (GFAP), epithelial membrane antigen and proliferation associated antigen Ki-67 were evaluated in a semi-quantitative or quantitative (Ki-67 and NeuN-index) fashion. We found p75 and NeuN to be expressed at significantly higher levels in supratentorial versus infratentorial tumors and GFAP to be expressed at significantly higher levels in infratentorial lesions. In conclusion, immunohistochemical expression of p75, NeuN and GFAP differed in ependymomas depending on tumor topography supporting the view of divergent cells of origin. However, because of the small sample size the results are of preliminary nature and replication in a larger cohort would be desirable.

AB - Ependymomas comprise 8 % of all intracranial tumors in children <15 years. Recent studies revealed that some supratentorial ependymomas express neuronal antigens and that high expression of neurofilament protein light polypeptide (NEFL) correlates with better clinical outcome. We retrospectively analyzed an expanded panel of proteins in 6 supratentorial, 15 posterior fossa and 4 spinal pediatric ependymomas by immunohistochemistry. Expression of high and low affinity neurotrophin receptors TrkA (NTRK1) and p75 (NGFR), pan-neuronal markers NeuN (RBFOX3) and synaptophysin, radial glial marker SOX9, adhesion molecules CD56 (NCAM) and CD44, junctional protein connexin 43 (GJA1), glial fibrillary acidic protein (GFAP), epithelial membrane antigen and proliferation associated antigen Ki-67 were evaluated in a semi-quantitative or quantitative (Ki-67 and NeuN-index) fashion. We found p75 and NeuN to be expressed at significantly higher levels in supratentorial versus infratentorial tumors and GFAP to be expressed at significantly higher levels in infratentorial lesions. In conclusion, immunohistochemical expression of p75, NeuN and GFAP differed in ependymomas depending on tumor topography supporting the view of divergent cells of origin. However, because of the small sample size the results are of preliminary nature and replication in a larger cohort would be desirable.

KW - Adolescent

KW - Antigens, Nuclear

KW - Child

KW - Child, Preschool

KW - Ependymoma

KW - Female

KW - Follow-Up Studies

KW - Glial Fibrillary Acidic Protein

KW - Humans

KW - Immunoenzyme Techniques

KW - Infant

KW - Infratentorial Neoplasms

KW - Male

KW - Neoplasm Grading

KW - Nerve Tissue Proteins

KW - Prognosis

KW - Receptors, Nerve Growth Factor

KW - Retrospective Studies

KW - Supratentorial Neoplasms

KW - Tumor Markers, Biological

U2 - 10.1007/s11060-013-1062-1

DO - 10.1007/s11060-013-1062-1

M3 - SCORING: Journal article

C2 - 23371454

VL - 112

SP - 191

EP - 197

JO - J NEURO-ONCOL

JF - J NEURO-ONCOL

SN - 0167-594X

IS - 2

ER -