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Suppression of experimental autoimmune encephalomyelitis by interleukin-10 transduced neural stem/progenitor cells

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Suppression of experimental autoimmune encephalomyelitis by interleukin-10 transduced neural stem/progenitor cells. / Klose, Juliane; Schmidt, Nils Ole; Melms, Arthur; Dohi, Makoto; Miyazaki, Jun-ichi; Bischof, Felix; Greve, Bernhard.

in: J NEUROINFLAMM, Jahrgang 10, 22.09.2013, S. 117.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Klose, J, Schmidt, NO, Melms, A, Dohi, M, Miyazaki, J, Bischof, F & Greve, B 2013, 'Suppression of experimental autoimmune encephalomyelitis by interleukin-10 transduced neural stem/progenitor cells', J NEUROINFLAMM, Jg. 10, S. 117. https://doi.org/10.1186/1742-2094-10-117

APA

Klose, J., Schmidt, N. O., Melms, A., Dohi, M., Miyazaki, J., Bischof, F., & Greve, B. (2013). Suppression of experimental autoimmune encephalomyelitis by interleukin-10 transduced neural stem/progenitor cells. J NEUROINFLAMM, 10, 117. https://doi.org/10.1186/1742-2094-10-117

Vancouver

Klose J, Schmidt NO, Melms A, Dohi M, Miyazaki J, Bischof F et al. Suppression of experimental autoimmune encephalomyelitis by interleukin-10 transduced neural stem/progenitor cells. J NEUROINFLAMM. 2013 Sep 22;10:117. https://doi.org/10.1186/1742-2094-10-117

Bibtex

@article{c625de662551468ea6a9f341b1c16c52,
title = "Suppression of experimental autoimmune encephalomyelitis by interleukin-10 transduced neural stem/progenitor cells",
abstract = "Neural stem/progenitor cells (NSPCs) have the ability to migrate into the central nervous system (CNS) to replace damaged cells. In inflammatory CNS disease, cytokine transduced neural stem cells may be used as vehicles to specifically reduce inflammation and promote cell replacement. In this study, we used NSPCs overexpressing IL-10, an immunomodulatory cytokine, in an animal model for CNS inflammation and multiple sclerosis (MS). Intravenous injection of IL-10 transduced neural stem/progenitor cells (NSPC(IL-10)) suppressed myelin oligodendrocyte glycoprotein aa 35-55 (MOG35-55)- induced experimental autoimmune encephalomyelitis (EAE) and, following intravenous injection, NSPC(IL-10) migrated to peripheral lymphoid organs and into the CNS. NSPC(IL-10 )suppressed antigen-specific proliferation and proinflammatory cytokine production of lymph node cells obtained from MOG35-55 peptide immunized mice. In this model, IL-10 producing NSPCs act via a peripheral immunosuppressive effect to attenuate EAE.",
keywords = "Animals, Encephalomyelitis, Autoimmune, Experimental, Enzyme-Linked Immunosorbent Assay, Female, Interleukin-10, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neural Stem Cells, Reverse Transcriptase Polymerase Chain Reaction, Stem Cell Transplantation, Transduction, Genetic",
author = "Juliane Klose and Schmidt, {Nils Ole} and Arthur Melms and Makoto Dohi and Jun-ichi Miyazaki and Felix Bischof and Bernhard Greve",
year = "2013",
month = sep,
day = "22",
doi = "10.1186/1742-2094-10-117",
language = "English",
volume = "10",
pages = "117",
journal = "J NEUROINFLAMM",
issn = "1742-2094",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Suppression of experimental autoimmune encephalomyelitis by interleukin-10 transduced neural stem/progenitor cells

AU - Klose, Juliane

AU - Schmidt, Nils Ole

AU - Melms, Arthur

AU - Dohi, Makoto

AU - Miyazaki, Jun-ichi

AU - Bischof, Felix

AU - Greve, Bernhard

PY - 2013/9/22

Y1 - 2013/9/22

N2 - Neural stem/progenitor cells (NSPCs) have the ability to migrate into the central nervous system (CNS) to replace damaged cells. In inflammatory CNS disease, cytokine transduced neural stem cells may be used as vehicles to specifically reduce inflammation and promote cell replacement. In this study, we used NSPCs overexpressing IL-10, an immunomodulatory cytokine, in an animal model for CNS inflammation and multiple sclerosis (MS). Intravenous injection of IL-10 transduced neural stem/progenitor cells (NSPC(IL-10)) suppressed myelin oligodendrocyte glycoprotein aa 35-55 (MOG35-55)- induced experimental autoimmune encephalomyelitis (EAE) and, following intravenous injection, NSPC(IL-10) migrated to peripheral lymphoid organs and into the CNS. NSPC(IL-10 )suppressed antigen-specific proliferation and proinflammatory cytokine production of lymph node cells obtained from MOG35-55 peptide immunized mice. In this model, IL-10 producing NSPCs act via a peripheral immunosuppressive effect to attenuate EAE.

AB - Neural stem/progenitor cells (NSPCs) have the ability to migrate into the central nervous system (CNS) to replace damaged cells. In inflammatory CNS disease, cytokine transduced neural stem cells may be used as vehicles to specifically reduce inflammation and promote cell replacement. In this study, we used NSPCs overexpressing IL-10, an immunomodulatory cytokine, in an animal model for CNS inflammation and multiple sclerosis (MS). Intravenous injection of IL-10 transduced neural stem/progenitor cells (NSPC(IL-10)) suppressed myelin oligodendrocyte glycoprotein aa 35-55 (MOG35-55)- induced experimental autoimmune encephalomyelitis (EAE) and, following intravenous injection, NSPC(IL-10) migrated to peripheral lymphoid organs and into the CNS. NSPC(IL-10 )suppressed antigen-specific proliferation and proinflammatory cytokine production of lymph node cells obtained from MOG35-55 peptide immunized mice. In this model, IL-10 producing NSPCs act via a peripheral immunosuppressive effect to attenuate EAE.

KW - Animals

KW - Encephalomyelitis, Autoimmune, Experimental

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Interleukin-10

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Neural Stem Cells

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Stem Cell Transplantation

KW - Transduction, Genetic

U2 - 10.1186/1742-2094-10-117

DO - 10.1186/1742-2094-10-117

M3 - SCORING: Journal article

C2 - 24053338

VL - 10

SP - 117

JO - J NEUROINFLAMM

JF - J NEUROINFLAMM

SN - 1742-2094

ER -